Proteasome degradation (WP183)

Homo sapiens

Authors

Nathan Salomonis , Frank Dennissen , Thomas Kelder , Martijn Van Iersel , Kristina Hanspers , Chris Evelo , Egon Willighagen , Martina Summer-Kutmon , Mick Eikelhof , and Eric Weitz

Activity

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Cited In

• Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients (2021).
• Gene expression regulated by abatacept associated with methotrexate and correlation with disease activity in rheumatoid arthritis (2020).
• Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).
• Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model (2020).
• Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease (2020).
• Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis (2017).

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

ubiquitin/proteasome degradation pathway

References

1. Basic Medical Research Award. The ubiquitin system. Hershko A, Ciechanover A, Varshavsky A. Nat Med. 2000 Oct;6(10):1073–81. PubMed Europe PMC Scholia
2. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, et al. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1380–7. PubMed Europe PMC Scholia