Genetic alterations of lung cancer (WP1968)

Rattus norvegicus

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Expression patterns of two major tumor suppressor pathways in lung cancer. These pathways are functionally linked to lung cancer and play role as a component of checkpoints and growth inhibitory pathways. Components which/who are activated in this pathway are Egfr, Erbb2, Rasl11b, and MYC in the Oncogenic singalling part. Frequent inactivated are TGF-beta R1/2, RB, p16INK4A, Tp53, and p14ARF, whie infrequent inactivated are Smad2 and Sma4. Both, the p14ARF/p53 and the p16INK4A/RB pathway lead to cell cycle arrest.

Authors

Gustav , Kristina Hanspers , Martina Summer-Kutmon , Christine Chichester , Jonathan Mélius , Alex Pico , Egon Willighagen , Friederike Ehrhart , Lauren J. Dupuis , and Marvin Martens

Activity

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

cancer pathway lung cancer pathway

Disease Ontology

lung cancer

Participants

Label Type Compact URI Comment
Pik3ca GeneProduct ensembl:ENSRNOG00000056371
Erbb2 GeneProduct ensembl:ENSRNOG00000006450
Egfr GeneProduct ensembl:ENSRNOG00000004332
ERK GeneProduct ensembl:ENSRNOG00000001849
Map2k1 GeneProduct ensembl:ENSRNOG00000010176
Raf1 GeneProduct ensembl:ENSRNOG00000010153
Rasl11b GeneProduct ensembl:ENSRNOG00000002097
Akt1 GeneProduct ensembl:ENSRNOG00000028629
MYC GeneProduct ensembl:ENSRNOG00000042556
Tgfb1 GeneProduct ensembl:ENSRNOG00000020652
Smad4 GeneProduct ensembl:ENSRNOG00000051965
Smad2 GeneProduct ensembl:ENSRNOG00000018140
TGF-beta R1/2 GeneProduct ensembl:ENSRNOG00000002418
Ccnd1 GeneProduct ensembl:ENSRNOG00000020918
Cdk4 GeneProduct ensembl:ENSRNOG00000025602
RB GeneProduct ensembl:ENSRNOG00000016029
E2F GeneProduct ensembl:ENSRNOG00000016708
Dmp1 GeneProduct ensembl:ENSRNOG00000002167
Mdm2 GeneProduct ensembl:ENSRNOG00000006304
CBP GeneProduct ensembl:ENSRNOG00000005330
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Atm GeneProduct ensembl:ENSRNOG00000029773
p300 GeneProduct ensembl:ENSRNOG00000000190
Ccne1 GeneProduct ensembl:ENSRNOG00000014786
Cdk2 GeneProduct ensembl:ENSRNOG00000006469
p21 GeneProduct ensembl:ENSRNOG00000000521
Pik3cd GeneProduct ensembl:ENSRNOG00000016846

References

  1. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, et al. Genes Dev. 1998 Aug 1;12(15):2424–33. PubMed Europe PMC Scholia
  2. Repression of p15INK4b expression by Myc through association with Miz-1. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, et al. Nat Cell Biol. 2001 Apr;3(4):392–9. PubMed Europe PMC Scholia
  3. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. Nat Cell Biol. 2001 Nov;3(11):973–82. PubMed Europe PMC Scholia
  4. Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Osada H, Takahashi T. Oncogene. 2002 Oct 21;21(48):7421–34. PubMed Europe PMC Scholia