Netrin-UNC5B signaling pathway (WP4747)

Homo sapiens

Authors

Yashwanth Subbannayya , Friederike Ehrhart , Lauren J. Dupuis , Marvin Martens , Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

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Cited In

• The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study (2022).

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cancer pathway

Disease Ontology

cancer

References

1. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M. J Neurosci. 1999 Jun 15;19(12):4938–47. PubMed Europe PMC Scholia
2. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P. EMBO J. 2001 Jun 1;20(11):2715–22. PubMed Europe PMC Scholia
3. MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion. Huang X, Cheng HJ, Tessier-Lavigne M, Jin Y. Neuron. 2002 May 16;34(4):563–76. PubMed Europe PMC Scholia
4. Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Tomizawa K, Iga N, Lu YF, Moriwaki A, Matsushita M, Li ST, et al. Nat Neurosci. 2003 Apr;6(4):384–90. PubMed Europe PMC Scholia
5. p53RDL1 regulates p53-dependent apoptosis. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H. Nat Cell Biol. 2003 Mar;5(3):216–23. PubMed Europe PMC Scholia
6. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. EMBO J. 2005 Mar 23;24(6):1192–201. PubMed Europe PMC Scholia
7. Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Wang W, Reeves WB, Ramesh G. Am J Physiol Renal Physiol. 2008 Apr;294(4):F739-47. PubMed Europe PMC Scholia
8. Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. Ren XR, Hong Y, Feng Z, Yang HM, Mei L, Xiong WC. Neurosignals. 2008;16(2–3):235–45. PubMed Europe PMC Scholia
9. Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Tang X, Jang SW, Okada M, Chan CB, Feng Y, Liu Y, et al. Nat Cell Biol. 2008 Jun;10(6):698–706. PubMed Europe PMC Scholia
10. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Lejmi E, Leconte L, Pédron-Mazoyer S, Ropert S, Raoul W, Lavalette S, et al. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12491–6. PubMed Europe PMC Scholia
11. Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. Wang W, Reeves WB, Ramesh G. Am J Physiol Renal Physiol. 2009 Apr;296(4):F723-9. PubMed Europe PMC Scholia
12. Unc5B associates with LARG to mediate the action of repulsive guidance molecule. Hata K, Kaibuchi K, Inagaki S, Yamashita T. J Cell Biol. 2009 Mar 9;184(5):737–50. PubMed Europe PMC Scholia
13. Interfering with multimerization of netrin-1 receptors triggers tumor cell death. Mille F, Llambi F, Guix C, Delloye-Bourgeois C, Guenebeaud C, Castro-Obregon S, et al. Cell Death Differ. 2009 Oct;16(10):1344–51. PubMed Europe PMC Scholia
14. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. Tadagavadi RK, Wang W, Ramesh G. J Immunol. 2010 Sep 15;185(6):3750–8. PubMed Europe PMC Scholia
15. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, et al. Mol Cell. 2010 Dec 22;40(6):863–76. PubMed Europe PMC Scholia
16. Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, et al. Dev Cell. 2011 Jan 18;20(1):33–46. PubMed Europe PMC Scholia
17. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. He K, Jang SW, Joshi J, Yoo MH, Ye K. Mol Biol Cell. 2011 Jun 1;22(11):1943–54. PubMed Europe PMC Scholia
18. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, et al. Nat Immunol. 2012 Jan 8;13(2):136–43. PubMed Europe PMC Scholia
19. Netrin-4 promotes mural cell adhesion and recruitment to endothelial cells. Lejmi E, Bouras I, Camelo S, Roumieux M, Minet N, Leré-Déan C, et al. Vasc Cell. 2014 Jan 28;6(1):1. PubMed Europe PMC Scholia
20. PKC α regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer. Liu J, Kong C ze, Gong D xin, Zhang Z, Zhu Y yan. BMC Cancer. 2014 Feb 15;14:93. PubMed Europe PMC Scholia
21. Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion. Hayano Y, Sasaki K, Ohmura N, Takemoto M, Maeda Y, Yamashita T, et al. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15226–31. PubMed Europe PMC Scholia
22. Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. Mediero A, Ramkhelawon B, Perez-Aso M, Moore KJ, Cronstein BN. J Bone Miner Res. 2015 May;30(5):837–54. PubMed Europe PMC Scholia
23. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Qi Q, Li DY, Luo HR, Guan KL, Ye K. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7255–60. PubMed Europe PMC Scholia
24. Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor. Lv J, Sun X, Ma J, Ma X, Zhang Y, Li F, et al. Biochem Biophys Res Commun. 2015 Aug 14;464(1):263–8. PubMed Europe PMC Scholia
25. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. An XZ, Zhao ZG, Luo YX, Zhang R, Tang XQ, Hao DL, et al. Oncotarget. 2016 Apr 26;7(17):24719–33. PubMed Europe PMC Scholia
26. Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B. Hayano Y, Takasu K, Koyama Y, Yamada M, Ogawa K, Minami K, et al. J Exp Med. 2016 Dec 12;213(13):2949–66. PubMed Europe PMC Scholia
27. The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Zhang F, Prahst C, Mathivet T, Pibouin-Fragner L, Zhang J, Genet G, et al. Nat Commun. 2016 Nov 24;7:13517. PubMed Europe PMC Scholia
28. Functional Roles of Netrin-1 in Osteoblast Differentiation. Sato T, Kokabu S, Enoki Y, Hayashi N, Matsumoto M, Nakahira M, et al. In Vivo. 2017;31(3):321–8. PubMed Europe PMC Scholia
29. Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats. Wang J, Zhai W, Yu Z, Sun L, Li H, Shen H, et al. Front Cell Neurosci. 2018 Jan 11;11:432. PubMed Europe PMC Scholia
30. A network map of netrin receptor UNC5B-mediated signaling. Bhat SA, Gurtoo S, Deolankar SC, Fazili KM, Advani J, Shetty R, et al. J Cell Commun Signal. 2019 Mar;13(1):121–7. PubMed Europe PMC Scholia