Apoptosis (WP787)

Gallus gallus

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Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Authors

Kristina Hanspers , Egon Willighagen , Christine Chichester , and Martina Summer-Kutmon

Activity

last edited

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
CASP9 GeneProduct ensembl:ENSGALG00000001366 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:842
MDM2 GeneProduct ensembl:ENSGALG00000009942 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4193
BAK1 GeneProduct ensembl:ENSGALG00000031493 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:578
TRAF3 GeneProduct ensembl:ENSGALG00000011389 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7187
IRF1 GeneProduct ensembl:ENSGALG00000006785 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3659
NFKB1 GeneProduct ensembl:ENSGALG00000012304 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4790
FAS GeneProduct ensembl:ENSGALG00000006351 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:355
BIRC2 GeneProduct ensembl:ENSGALG00000017186 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:329
DIABLO GeneProduct ensembl:ENSGALG00000004412 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:56616
AKT1 GeneProduct ensembl:ENSGALG00000011620 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:207
GZMB GeneProduct ensembl:ENSGALG00000044661 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3002
TNFRSF21 GeneProduct ensembl:ENSGALG00000016719 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:27242
NFKBIA GeneProduct ensembl:ENSGALG00000027864 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4792
CASP1 GeneProduct ensembl:ENSGALG00000001049 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:834
RIPK1 GeneProduct ensembl:ENSGALG00000012827 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8737
IRF2 GeneProduct ensembl:ENSGALG00000010642 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3660
NFKBIB GeneProduct ensembl:ENSGALG00000029691 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4793
CASP4 GeneProduct ensembl:ENSGALG00000001049 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:837
IRF6 GeneProduct ensembl:ENSGALG00000001405 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3664
CASP3 GeneProduct ensembl:ENSGALG00000010638 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:836
PRF1 GeneProduct ensembl:ENSGALG00000045916 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5551
TNFRSF1A GeneProduct ensembl:ENSGALG00000039461 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7132
IGF1R GeneProduct ensembl:ENSGALG00000040651 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3480
RELA GeneProduct ensembl:ENSGALG00000039409 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5970
CHUK GeneProduct ensembl:ENSGALG00000003289 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1147
APAF1 GeneProduct ensembl:ENSGALG00000011531 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:317
TNFRSF1B GeneProduct ensembl:ENSGALG00000034213 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7133
CASP10 GeneProduct ensembl:ENSGALG00000046494 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:843
BIRC3 GeneProduct ensembl:ENSGALG00000017186 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:330
BID GeneProduct ensembl:ENSGALG00000013039 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:637
TNFRSF25 GeneProduct ensembl:ENSGALG00000026499 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8718
MAPK10 GeneProduct ensembl:ENSGALG00000011109 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5602
TRAF1 GeneProduct ensembl:ENSGALG00000001583 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7185
IKBKB GeneProduct ensembl:ENSGALG00000031832 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3551
IRF5 GeneProduct ensembl:ENSGALG00000039982 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3663
DFFA GeneProduct ensembl:ENSGALG00000002820 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1676
CYCS GeneProduct ensembl:ENSGALG00000011020 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:54205
CASP2 GeneProduct ensembl:ENSGALG00000014698 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:835
TP73 GeneProduct ensembl:ENSGALG00000001006 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7161
SCAF11 GeneProduct ensembl:ENSGALG00000028849 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9169
CASP7 GeneProduct ensembl:ENSGALG00000008933 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:840
MYC GeneProduct ensembl:ENSGALG00000033631 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
IGF2 GeneProduct ensembl:ENSGALG00000035282 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3481
CRADD GeneProduct ensembl:ENSGALG00000011297 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8738
BOK GeneProduct ensembl:ENSGALG00000005772 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:666
TRAF2 GeneProduct ensembl:ENSGALG00000042838 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7186
CFLAR GeneProduct ensembl:ENSGALG00000008240 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8837
PIK3R1 GeneProduct ensembl:ENSGALG00000014786 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5295
TRADD GeneProduct ensembl:ENSGALG00000003195 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8717
BIRC5 GeneProduct ensembl:ENSGALG00000008713 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:332
IGF-I GeneProduct ensembl:ENSGALG00000012755 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3479
TNFRSF10B GeneProduct ensembl:ENSGALG00000000452 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8795
JUN GeneProduct ensembl:ENSGALG00000010870 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3725
BNIP3L GeneProduct ensembl:ENSGALG00000043405 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:665
CAD GeneProduct ensembl:ENSGALG00000036295 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1677
BCL2 GeneProduct ensembl:ENSGALG00000012885 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:596
IRF7 GeneProduct ensembl:ENSGALG00000014297 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3665
BCL2L1 GeneProduct ensembl:ENSGALG00000006211 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:598
IRF4 GeneProduct ensembl:ENSGALG00000043913 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3662
NFKBIE GeneProduct ensembl:ENSGALG00000044525 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4794
MAP2K4 GeneProduct ensembl:ENSGALG00000032178 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6416
CDKN2A GeneProduct ensembl:ENSGALG00000026137 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1029
CASP8 GeneProduct ensembl:ENSGALG00000008355 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:841
BIRC4 GeneProduct ensembl:ENSGALG00000008491 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:331
TNFSF6 GeneProduct ensembl:ENSGALG00000003076 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:356
TNFSF10 GeneProduct ensembl:ENSGALG00000009179 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8743
HELLS GeneProduct ensembl:ENSGALG00000005451 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3070
FADD GeneProduct ensembl:ENSGALG00000007625 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8772
MCL1 GeneProduct ensembl:ENSGALG00000044383 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4170
CASP6 GeneProduct ensembl:ENSGALG00000012186 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:839
MAP3K1 GeneProduct ensembl:ENSGALG00000014718 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4214
TP63 GeneProduct ensembl:ENSGALG00000007324 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8626

References

  1. Regulation of p53 in response to DNA damage. Lakin ND, Jackson SP. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
  2. mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  3. The p53-MDM2 network: from oscillations to apoptosis. Bose I, Ghosh B. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
  4. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia