Endoderm differentiation (WP2853)
Homo sapiens
Model depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109 Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2853 CPTAC Assay Portal]
Authors
Nathan Salomonis , Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , Alex Pico , Friederike Ehrhart , Susan Coort , and Eric WeitzActivity
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Cited In
- The m6A(m)-independent role of FTO in regulating WNT signaling pathways (2022).
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
- Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR (2022).
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Organisms
Homo sapiensCommunities
ExRNAAnnotations
Pathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| STAT1 | GeneProduct | ensembl:ENSG00000115415 | |
| NANOG | GeneProduct | ensembl:ENSG00000111704 | |
| CDYL | GeneProduct | uniprot:Q9Y232 | |
| SFMBT1 | GeneProduct | uniprot:Q9UHJ3 | |
| UBR5 | GeneProduct | uniprot:O95071 | |
| SOX21 | GeneProduct | uniprot:Q9Y651 | |
| C1QBP | GeneProduct | uniprot:Q07021 | |
| BTAF1 | GeneProduct | uniprot:O14981 | |
| ZIC3 | GeneProduct | uniprot:O60481 | |
| PTHLH | GeneProduct | ensembl:ENSG00000087494 | |
| EPB41L5 | GeneProduct | ensembl:ENSG00000115109 | |
| LAMC1 | GeneProduct | ensembl:ENSG00000135862 | |
| PRDM14 | GeneProduct | ensembl:ENSG00000147596 | |
| SMAD3 | GeneProduct | ensembl:ENSG00000166949 | |
| NME1 | GeneProduct | uniprot:P15531 | |
| RTF1 | GeneProduct | ensembl:ENSG00000137815 | |
| RFX7 | GeneProduct | uniprot:Q2KHR2 | |
| TGFB1 | GeneProduct | ensembl:ENSG00000105329 | |
| NODAL | GeneProduct | ensembl:ENSG00000156574 | |
| RARG | GeneProduct | uniprot:P13631 | |
| BPTF | GeneProduct | ensembl:ENSG00000171634 | |
| TRIM71 | GeneProduct | uniprot:Q2Q1W2 | |
| SOX17 | GeneProduct | ensembl:ENSG00000164736 | |
| FOXN3 | GeneProduct | uniprot:O00409 | |
| GATA4 | GeneProduct | ensembl:ENSG00000136574 | |
| MBTD1 | GeneProduct | uniprot:Q05BQ5 | |
| HNF1B | GeneProduct | ensembl:ENSG00000275410 | |
| NAA15 | GeneProduct | uniprot:Q9BXJ9 | |
| PAX9 | GeneProduct | ensembl:ENSG00000198807 | |
| LRPPRC | GeneProduct | uniprot:P42704 | |
| LEO1 | GeneProduct | ensembl:ENSG00000166477 | |
| OTX2 | GeneProduct | ensembl:ENSG00000165588 | |
| CTBP2 | GeneProduct | uniprot:P56545 | |
| CEBPZ | GeneProduct | uniprot:Q03701 | |
| DAB2 | GeneProduct | ensembl:ENSG00000153071 | |
| WWC1 | GeneProduct | uniprot:Q8IX03 | |
| DNMT3B | GeneProduct | uniprot:Q9UBC3 | |
| SFRP1 | GeneProduct | ensembl:ENSG00000104332 | |
| GDF3 | GeneProduct | ensembl:ENSG00000184344 | |
| WDHD1 | GeneProduct | uniprot:O75717 | |
| PBX1 | GeneProduct | uniprot:P40424 | |
| KDM4A | GeneProduct | uniprot:O75164 | |
| NOTCH1 | GeneProduct | ensembl:ENSG00000148400 | |
| SP4 | GeneProduct | uniprot:Q02446 | |
| HOXA1 | GeneProduct | ensembl:ENSG00000105991 | |
| EXT1 | GeneProduct | ensembl:ENSG00000182197 | |
| PAF1 | GeneProduct | ensembl:ENSG00000006712 | |
| JARID2 | GeneProduct | uniprot:Q92833 | |
| PABPC1 | GeneProduct | ensembl:ENSG00000070756 | |
| EOMES | GeneProduct | ensembl:ENSG00000163508 | |
| POU5F1 | GeneProduct | ensembl:ENSG00000204531 | |
| ONECUT1 | GeneProduct | ensembl:ENSG00000169856 | |
| TCF7L1 | GeneProduct | uniprot:Q9HCS4 | |
| FOXA1 | GeneProduct | ensembl:ENSG00000129514 | |
| NKX2-1 | GeneProduct | ensembl:ENSG00000136352 | |
| CTNNB1 | GeneProduct | ensembl:ENSG00000168036 | |
| TCF7 | GeneProduct | ensembl:ENSG00000081059 | |
| MIXL1 | GeneProduct | ensembl:ENSG00000185155 | |
| ZNF462 | GeneProduct | uniprot:Q96JM2 | |
| CTR9 | GeneProduct | ensembl:ENSG00000198730 | |
| TAF4B | GeneProduct | uniprot:Q92750 | |
| DUSP5 | GeneProduct | ensembl:ENSG00000138166 | |
| SMAD4 | GeneProduct | ensembl:ENSG00000141646 | |
| ZFHX4 | GeneProduct | uniprot:Q86UP3 | |
| TAF5 | GeneProduct | uniprot:Q15542 | |
| WNT8A | GeneProduct | ensembl:ENSG00000061492 | |
| ELAVL1 | GeneProduct | ensembl:ENSG00000066044 | |
| MAD2L2 | GeneProduct | uniprot:Q9UI95 | |
| CER1 | GeneProduct | ensembl:ENSG00000147869 | |
| FOXA2 | GeneProduct | ensembl:ENSG00000125798 | |
| FOXO1 | GeneProduct | uniprot:Q12778 | |
| MTF2 | GeneProduct | uniprot:Q9Y483 | |
| DKK1 | GeneProduct | ensembl:ENSG00000107984 | |
| ZIC5 | GeneProduct | uniprot:Q96T25 | |
| PAX3 | GeneProduct | uniprot:P23760 | |
| APP | GeneProduct | ensembl:ENSG00000142192 | |
| AEBP2 | GeneProduct | uniprot:Q6ZN18 | |
| TNRC6C | GeneProduct | ensembl:ENSG00000078687 | |
| BMPR1A | GeneProduct | ensembl:ENSG00000107779 | |
| TBX21 | GeneProduct | ensembl:ENSG00000073861 | |
| SMAD2 | GeneProduct | ensembl:ENSG00000175387 | |
| NCAPG2 | GeneProduct | uniprot:Q86XI2 | |
| CAND1 | GeneProduct | ensembl:ENSG00000111530 | |
| BMP7 | GeneProduct | ensembl:ENSG00000101144 | |
| SOX2 | GeneProduct | ensembl:ENSG00000181449 | |
| ASCC3 | GeneProduct | uniprot:Q8N3C0 | |
| NOG | GeneProduct | ensembl:ENSG00000183691 | |
| ZBTB17 | GeneProduct | uniprot:Q13105 | |
| DUSP4 | GeneProduct | ensembl:ENSG00000120875 | |
| CDC73 | GeneProduct | ensembl:ENSG00000134371 | |
| ZNF281 | GeneProduct | uniprot:Q9Y2X9 | |
| LEF1 | GeneProduct | ensembl:ENSG00000138795 | |
| HOXC11 | GeneProduct | ensembl:ENSG00000123388 | |
| GRHL2 | GeneProduct | uniprot:Q6ISB3 | |
| TCEAL2 | GeneProduct | uniprot:Q9H3H9 | |
| HHEX | GeneProduct | ensembl:ENSG00000152804 | |
| GATA6 | GeneProduct | ensembl:ENSG00000141448 | |
| JARID2 | GeneProduct | ensembl:ENSG00000008083 | |
| TET1 | GeneProduct | uniprot:Q8NFU7 | |
| GLI2 | GeneProduct | uniprot:P10070 | |
| LHX1 | GeneProduct | ensembl:ENSG00000273706 | |
| MIR653 | GeneProduct | ensembl:ENSG00000199143 | |
| ELK4 | GeneProduct | uniprot:P28324 | |
| DIP2A | GeneProduct | uniprot:Q14689 | |
| PIAS1 | GeneProduct | uniprot:O75925 | |
| CRTC1 | GeneProduct | uniprot:Q6UUV9 | |
| AHDC1 | GeneProduct | uniprot:Q5TGY3 | |
| PBX3 | GeneProduct | uniprot:P40426 | |
| NLK | GeneProduct | uniprot:Q9UBE8 | |
| BCORL1 | GeneProduct | uniprot:Q5H9F3 | |
| PLCH1 | GeneProduct | uniprot:Q4KWH8 | |
| WDFY2 | GeneProduct | uniprot:Q96P53 | |
| PARP8 | GeneProduct | uniprot:Q8N3A8 | |
| SESN1 | GeneProduct | uniprot:Q9Y6P5 | |
| RGS10 | GeneProduct | uniprot:O43665 | |
| CUL4B | GeneProduct | uniprot:Q13620 | |
| DDAH1 | GeneProduct | uniprot:O94760 | |
| NABP2 | GeneProduct | uniprot:Q9BQ15 | |
| ELP4 | GeneProduct | uniprot:Q96EB1 | |
| SCHIP1 | GeneProduct | uniprot:Q9P0W5 | |
| TRIM5 | GeneProduct | uniprot:Q9C035 | |
| CEP250 | GeneProduct | uniprot:Q9BV73 | |
| PHF6 | GeneProduct | uniprot:Q8IWS0 | |
| HPRT1 | GeneProduct | uniprot:P00492 | |
| TCF4 | GeneProduct | uniprot:P15884 | |
| TOX3 | GeneProduct | uniprot:O15405 | |
| SLC2A12 | GeneProduct | uniprot:Q8TD20 | |
| ACACA | GeneProduct | uniprot:Q13085 | |
| EMSY | GeneProduct | uniprot:Q7Z589 | |
| TOX | GeneProduct | uniprot:O94900 | |
| TRERF1 | GeneProduct | uniprot:Q96PN7 | |
| ATP8B2 | GeneProduct | uniprot:P98198 | |
| VAV3 | GeneProduct | uniprot:Q9UKW4 | |
| MIR373 | GeneProduct | ensembl:ENSG00000199143 | |
| MIR375 | GeneProduct | ensembl:ENSG00000198973 | |
| MIR141 | GeneProduct | ensembl:ENSG00000207708 | |
| NR3C1 | GeneProduct | ensembl:ENSG00000113580 | |
| DUSP2 | GeneProduct | ensembl:ENSG00000158050 | |
| EZH2 | GeneProduct | ensembl:ENSG00000106462 | |
| FOXH1 | GeneProduct | ensembl:ENSG00000160973 | |
| SIAH2 | GeneProduct | ensembl:ENSG00000181788 | |
| RAB38 | GeneProduct | ensembl:ENSG00000123892 | |
| APC | GeneProduct | ensembl:ENSG00000134982 | |
| SOX7 | GeneProduct | ensembl:ENSG00000171056 | |
| MAP2K3 | GeneProduct | ensembl:ENSG00000034152 | |
| WNT3 | GeneProduct | ensembl:ENSG00000108379 |
References
- Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. Futaki S, Hayashi Y, Emoto T, Weber CN, Sekiguchi K. Mol Cell Biol. 2004 Dec;24(23):10492–503. PubMed Europe PMC Scholia
- Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, et al. Development. 2008 May;135(10):1791–801. PubMed Europe PMC Scholia
- Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Putzke AP, Rothman JH. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16154–9. PubMed Europe PMC Scholia
- Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Kim SW, Yoon SJ, Chuong E, Oyolu C, Wills AE, Gupta R, et al. Dev Biol. 2011 Sep 15;357(2):492–504. PubMed Europe PMC Scholia
- FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Sui L, Mfopou JK, Geens M, Sermon K, Bouwens L. Biochem Biophys Res Commun. 2012 Sep 28;426(3):380–5. PubMed Europe PMC Scholia
- MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Chappell J, Sun Y, Singh A, Dalton S. Genes Dev. 2013 Apr 1;27(7):725–33. PubMed Europe PMC Scholia
- Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development. Kang N, Won M, Rhee M, Ro H. Mol Cells. 2014 May;37(5):389–98. PubMed Europe PMC Scholia