T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection (WP3863)
Homo sapiens
This pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway"(see bibliography). The pathway displays the T-cell receptors of homo sapiens when infected with the disease Staphylococcus Enterotoxin B. The binding of a superantigen to the T cell receptor results in a protein signaling pathway resulting in cell proliferation, differentiation, and immune response due to altered DNA expression. SEB refers to Staphylococcal Enterotoxin B.
Authors
AAR&Co , Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , Alex Pico , Chris Evelo , Andika Tan , and Eric WeitzActivity
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Cited In
- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- Finding disease modules for cancer and COVID-19 in gene co-expression networks with the Core&Peel method (2020).
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Organisms
Homo sapiensCommunities
DiseasesAnnotations
Disease Ontology
toxic shock syndromePathway Ontology
immune response pathway infectious disease pathwayCell Type Ontology
T cellReferences
- A model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathway. Tomar N, De RK. PLoS One. 2013 Dec 6;8(12):e80918. PubMed Europe PMC Scholia