IL-1 signaling pathway (WP355)

Rattus norvegicus

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The interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor, IL1R2. Upon binding to the ligands, interleukin-1 alpha or beta, IL1R1 interacts with IL-1 receptor accessory protein (IL1RAP) to activate the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_13

Authors

Akhilesh Pandey , Christine Chichester , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

interleukin-1 signaling pathway

Participants

Label Type Compact URI Comment
Il1b GeneProduct ncbigene:24494
Il1rn GeneProduct ncbigene:60582
Il1rap GeneProduct ncbigene:25466
Il1r1 GeneProduct ncbigene:25663
Il1a GeneProduct ncbigene:24493
Il1r2 GeneProduct ncbigene:117022
Myd88 GeneProduct ncbigene:301059
IRAK4 GeneProduct ncbigene:300177
IRAK3 GeneProduct ncbigene:314870
TOLLIP GeneProduct ncbigene:361677
PELI1 GeneProduct ncbigene:305549
MAP3K7 GeneProduct ncbigene:313121
MAP3K7IP1 GeneProduct ncbigene:315139
MAPK8 GeneProduct ncbigene:116554
MAP3K14 GeneProduct ncbigene:360640
CHUK GeneProduct ncbigene:309361
IKBKAP GeneProduct ncbigene:140934
SQSTM1 GeneProduct ncbigene:113894
PRKCZ GeneProduct ncbigene:25522
Ptpns1 GeneProduct ncbigene:25528
PTPN11 GeneProduct ncbigene:25622
Irak2 GeneProduct ncbigene:362418
CAPN1 GeneProduct ncbigene:29153
CAPNS1 GeneProduct ncbigene:29156
CASP1 GeneProduct ncbigene:25166
MAPK1 GeneProduct ncbigene:116590
AKT1 GeneProduct ncbigene:24185
Traf6 GeneProduct ncbigene:311245
NFKBIA GeneProduct ncbigene:25493
NFKBIB GeneProduct ncbigene:81525
MAP2K1 GeneProduct ncbigene:170851
MAPK3 GeneProduct ncbigene:50689
RELA GeneProduct ncbigene:309165
NFKB1 GeneProduct ncbigene:81736
PLCG1 GeneProduct ncbigene:25738
Irak1 GeneProduct ncbigene:363520
Irak4 GeneProduct ncbigene:300177

References