Molecular pathway for oxidative stress (WP5477)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Oxidative stress occurs when there is an imbalance of free radicals and antioxidants in the body, resulting in too many free radicals and not enough antioxidants. This excess of free radicals can damage the body's cells and tissues.

Authors

Burritaco , Kristina Hanspers , Alex Pico , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway oxidative stress response pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Reactive oxigen species Metabolite chebi:26523
FoxO GeneProduct ensembl:ENSG00000150907
Bcl-2 GeneProduct ensembl:ENSG00000171791
MSK1 GeneProduct ensembl:ENSG00000100784
TSC1/2 GeneProduct ensembl:ENSG00000165699
ATF2 GeneProduct ensembl:ENSG00000115966
AP1 GeneProduct ensembl:ENSG00000170345
PI3K GeneProduct ensembl:ENSG00000121879
NQO-1 GeneProduct ensembl:ENSG00000181019
Cycline-E GeneProduct ensembl:ENSG00000105173
CAT GeneProduct ensembl:ENSG00000121691
JNK1/2/3 GeneProduct ensembl:ENSG00000107643
ICAM-1 GeneProduct ensembl:ENSG00000090339
NF-kB GeneProduct ensembl:ENSG00000109320
IL-1 GeneProduct ensembl:ENSG00000115008
IkB GeneProduct ensembl:ENSG00000104365
IL-8 GeneProduct ensembl:ENSG00000169429
Keap-1 GeneProduct ensembl:ENSG00000079999
P53 GeneProduct ensembl:ENSG00000141510
NOX1 GeneProduct ensembl:ENSG00000007952
SIRT1 GeneProduct ensembl:ENSG00000096717
GSH GeneProduct ensembl:ENSG00000169840
Cul3 GeneProduct ensembl:ENSG00000036257
CDK2 GeneProduct ensembl:ENSG00000123374
ATR GeneProduct ensembl:ENSG00000175054
NRF2 GeneProduct ensembl:ENSG00000116044
Bcl-xL GeneProduct ensembl:ENSG00000171552
MAP3K5/ASK1/2 GeneProduct ensembl:ENSG00000197442
PTEN GeneProduct ensembl:ENSG00000171862
AKT GeneProduct ensembl:ENSG00000142208
HO-1 GeneProduct ensembl:ENSG00000100292
PIP3 GeneProduct ensembl:ENSG00000074706
COX-2 GeneProduct ensembl:ENSG00000073756
IKKs GeneProduct ensembl:ENSG00000269335
Pink1 GeneProduct ensembl:ENSG00000158828
IL-6 GeneProduct ensembl:ENSG00000136244
Chk1 GeneProduct ensembl:ENSG00000149554
P21 GeneProduct ensembl:ENSG00000124762
Rheb GeneProduct ensembl:ENSG00000106615
MKK4/7 GeneProduct ensembl:ENSG00000065559
MDM2 GeneProduct ensembl:ENSG00000135679
MKK3/6 GeneProduct ensembl:ENSG00000034152
PIP2 GeneProduct ensembl:ENSG00000159763
CREB GeneProduct ensembl:ENSG00000118260
NRF-1 GeneProduct ensembl:ENSG00000106459
P38 GeneProduct ensembl:ENSG00000112062
TNF-alpha GeneProduct ensembl:ENSG00000232810
SOD2 GeneProduct ensembl:ENSG00000291237
mTORC1 GeneProduct ensembl:ENSG00000198793
iNOS GeneProduct ensembl:ENSG00000007171

References

  1. Crosstalk of reactive oxygen species and NF-κB signaling. Morgan MJ, Liu Z gang. Cell Res. 2011 Jan;21(1):103–15. PubMed Europe PMC Scholia
  2. Therapeutic targets in the ASK1-dependent stress signaling pathways. Hayakawa R, Hayakawa T, Takeda K, Ichijo H. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88(8):434–53. PubMed Europe PMC Scholia
  3. Reactive oxygen species in the activation of MAP kinases. Son Y, Kim S, Chung HT, Pae HO. Methods Enzymol. 2013;528:27–48. PubMed Europe PMC Scholia
  4. Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology. Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K. Biomolecules. 2020 Feb 17;10(2):320. PubMed Europe PMC Scholia
  5. The multifaceted role of reactive oxygen species in tumorigenesis. Kirtonia A, Sethi G, Garg M. Cell Mol Life Sci. 2020 Nov;77(22):4459–83. PubMed Europe PMC Scholia
  6. Emerging role of NRF2 in ROS-mediated tumor chemoresistance. Xue D, Zhou X, Qiu J. Biomed Pharmacother. 2020 Nov;131:110676. PubMed Europe PMC Scholia
  7. The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. Kma L, Baruah TJ. Biotechnol Appl Biochem. 2022 Feb;69(1):248–64. PubMed Europe PMC Scholia
  8. Oxidative Stress and ROS-Mediated Signaling in Leukemia: Novel Promising Perspectives to Eradicate Chemoresistant Cells in Myeloid Leukemia. Trombetti S, Cesaro E, Catapano R, Sessa R, Lo Bianco A, Izzo P, et al. Int J Mol Sci. 2021 Feb 28;22(5):2470. PubMed Europe PMC Scholia
  9. Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival. Foo BJA, Eu JQ, Hirpara JL, Pervaiz S. Oxid Med Cell Longev. 2021 Nov 3;2021:1341604. PubMed Europe PMC Scholia
  10. Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy. Hammad M, Raftari M, Cesário R, Salma R, Godoy P, Emami SN, et al. Antioxidants (Basel). 2023 Jun 30;12(7):1371. PubMed Europe PMC Scholia