Fatty acid biosynthesis (WP568)
Drosophila melanogaster
The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway.
Authors
Kdahlquist , Chris Evelo , Christine Chichester , Egon Willighagen , Andra Waagmeester , Denise Slenter , Lauren J. Dupuis , Finterly Hu , Eric Weitz , and Alex PicoActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Drosophila melanogasterCommunities
Annotations
Pathway Ontology
fatty acid biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Butyryl-ACP | Metabolite | chebi:3247 | |
| Malonyl-CoA | Metabolite | hmdb:HMDB0001175 | |
| 3-ketoacyl-CoA | Metabolite | chebi:57347 | |
| beta-hydroxybutyryl | Metabolite | pubchem.compound:644065 | |
| Pyruvate | Metabolite | chemspider:96901 | |
| Long-Chain fatty acid | Metabolite | chebi:15904 | |
| Acetyl-CoA | Metabolite | chemspider:392413 | |
| Palmitate | Metabolite | chemspider:440215 | |
| Acetoacetyl-ACP | Metabolite | chebi:2393 | |
| Malonyl-ACP | Metabolite | kegg.compound:C01209 | |
| Oxaloacetate | Metabolite | chemspider:2509917 | |
| Citrate | Metabolite | chemspider:29081 | |
| Fatty acyl CoA | Metabolite | chebi:37554 | |
| Acyl-CoA (n+2) | Metabolite | chebi:37554 | |
| Acetyl-ACP | Metabolite | kegg.compound:C03939 | |
| yip2 | GeneProduct | ncbigene:34313 | |
| AcCoAS | GeneProduct | ncbigene:40348 | |
| CG3523 | GeneProduct | ncbigene:33524 | |
| SCD | GeneProduct | ncbigene:252579 | |
| CG6543 | GeneProduct | ncbigene:36536 | |
| CG16935 | GeneProduct | ncbigene:36540 | |
| CG6984 | GeneProduct | ncbigene:36926 | |
| CG1516 | GeneProduct | ncbigene:36020 | |
| ATPCL | GeneProduct | ncbigene:36760 | |
| CG11198 | GeneProduct | ncbigene:35761 | |
| CG3961 | GeneProduct | ncbigene:40056 | |
| l(2)44DEa | GeneProduct | ncbigene:46068 | |
| CG9577 | GeneProduct | ncbigene:33016 |
References
- Purification and characterization of [acyl-carrier-protein] acetyltransferase from Escherichia coli. Lowe PN, Rhodes S. Biochem J. 1988 Mar 15;250(3):789–96. PubMed Europe PMC Scholia
- Fatty acid metabolism in Drosophila melanogaster: interaction between dietary fatty acids and de novo synthesis. Keith AD. Comp Biochem Physiol. 1967 Jun;21(3):587–600. PubMed Europe PMC Scholia
- Biosynthesis of medium chain fatty acids in Drosophila melanogaster. de Renobales M, Blomquist GJ. Arch Biochem Biophys. 1984 Feb 1;228(2):407–14. PubMed Europe PMC Scholia
- Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system. Parvy JP, Napal L, Rubin T, Poidevin M, Perrin L, Wicker-Thomas C, et al. PLoS Genet. 2012;8(8):e1002925. PubMed Europe PMC Scholia