Thymic stromal lymphopoietin (TSLP) signaling (WP2203)

Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine involved in regulation of a broad spectrum of biological processes. The TSLP receptor complex consists of the IL-7 receptor alpha subunit and its unique TSLPR subunit (gene symbol CRLF2). TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP can also activate dendritic cells, CD4+ T cells and CD8+ T cells. TSLP not only activate the JAK/STAT pathway but also induce phosphorylation of other signaling molecules including PI3K/Akt, ERK1/2 and JNKs. Aberrant TSLP signaling is implicated in a number of the development of diseases, including asthma, atopic dermatitis, eosinophilic eosophagitis and acute lymphoid leukemia. Description source: [http://www.netpath.org/pathways?path_id=NetPath_24 NetPath] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2203 CPTAC Assay Portal].

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