Thyroid stimulating hormone (TSH) signaling (WP2032)
Homo sapiens
Human thyroid-stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in the regulation of the hypothalamus-pituitary-thyroid axis by stimulating production and secretion of the thyroid hormone from the thyroid gland and – on a longer time scale – growth and differentiation of thyrocytes. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules. NetPath is a collaborative project between PandeyLab at Johns Hopkins University and the Institute of Bioinformatics. If you use this pathway, please cite the NetPath website until the pathway is published. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
Authors
Dr. Renu Goel , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Alex Pico , Zahra Roudbari , Marianthi Kalafati , Lauren J. Dupuis , Denise Slenter , Egon Willighagen , Eric Weitz , and Johannes W. DietrichActivity
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Cited In
- Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis (2017).
- A Signaling Network of Thyroid-Stimulating Hormone (2013).
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Pathway Ontology
thyroid-stimulating hormone signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CCND3 | GeneProduct | ncbigene:896 | |
| MAP2K1 | GeneProduct | ncbigene:5604 | |
| MAPK3 | GeneProduct | ncbigene:5595 | |
| PIK3R2 | GeneProduct | ncbigene:5296 | |
| BRAF | GeneProduct | ncbigene:673 | |
| STAT1 | GeneProduct | ncbigene:6772 | |
| CGA | GeneProduct | ncbigene:1081 | |
| RAF1 | GeneProduct | ncbigene:5894 | |
| SCRIB | GeneProduct | ncbigene:23513 | |
| HRAS | GeneProduct | ncbigene:3265 | |
| KCNIP3 | GeneProduct | ncbigene:30818 | |
| GNB1 | GeneProduct | ncbigene:2782 | |
| GNG2 | GeneProduct | ncbigene:54331 | |
| TSHB | GeneProduct | ncbigene:7252 | |
| TSHR | GeneProduct | ncbigene:7253 | |
| STAT3 | GeneProduct | ncbigene:6774 | |
| PDPK1 | GeneProduct | ncbigene:5170 | |
| PIK3CA | GeneProduct | ncbigene:5290 | |
| PIK3R1 | GeneProduct | ncbigene:5295 | |
| CDK2 | GeneProduct | ncbigene:1017 | |
| SRC | GeneProduct | ncbigene:6714 | |
| MAP2K3 | GeneProduct | ncbigene:5606 | |
| MAP2K6 | GeneProduct | ncbigene:5608 | |
| AKT1 | GeneProduct | ncbigene:207 | |
| PRKCZ | GeneProduct | ncbigene:5934 | |
| RPS6KB1 | GeneProduct | ncbigene:6198 | |
| MAPK1 | GeneProduct | ncbigene:5594 | |
| RB1 | GeneProduct | ncbigene:5925 | |
| CREB1 | GeneProduct | ncbigene:1385 | |
| PDE4D | GeneProduct | ncbigene:5144 | |
| GNAI1 | GeneProduct | ncbigene:2770 | |
| GNA13 | GeneProduct | ncbigene:10672 | |
| GNAI2 | GeneProduct | ncbigene:2771 | |
| GNA12 | GeneProduct | ncbigene:2768 | |
| GNAO1 | GeneProduct | ncbigene:2775 | |
| GNAQ | GeneProduct | ncbigene:2776 | |
| GNAI3 | GeneProduct | ncbigene:2773 | |
| MYL12B | GeneProduct | ncbigene:103910 | |
| RALGDS | GeneProduct | ncbigene:5900 | |
| GNAS | GeneProduct | ncbigene:2778 | |
| JAK2 | GeneProduct | ncbigene:3717 | |
| JAK1 | GeneProduct | ncbigene:3716 | |
| RPS6 | GeneProduct | ncbigene:6194 | |
| MTOR | GeneProduct | ncbigene:2475 | |
| ADCY2 | GeneProduct | ncbigene:108 | |
| ADCY3 | GeneProduct | ncbigene:109 | |
| CDK4 | GeneProduct | ncbigene:1019 | |
| RPS6KA1 | GeneProduct | ncbigene:6195 | |
| PLD1 | GeneProduct | ncbigene:5337 | |
| PLCB1 | GeneProduct | ncbigene:23236 | |
| RAP1B | GeneProduct | ncbigene:5908 | |
| RAP1A | GeneProduct | ncbigene:5906 | |
| RHOA | GeneProduct | ncbigene:3480 | |
| CCNE1 | GeneProduct | ncbigene:898 | |
| MAPK14 | GeneProduct | ncbigene:1432 | |
| CDKN1B | GeneProduct | ncbigene:1027 | |
| RAP1GAP | GeneProduct | ncbigene:5909 | |
| APEX1 | GeneProduct | ncbigene:328 |
References
- NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia
- A comprehensive curated resource for follicle stimulating hormone signaling. Telikicherla D, Ambekar A, Palapetta SM, Dwivedi SB, Raju R, Sharma J, et al. BMC Res Notes. 2011 Oct 13;4:408. PubMed Europe PMC Scholia