Cholesterol biosynthesis pathway (WP197)
Homo sapiens
Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP197 CPTAC Assay Portal]
Authors
Michael Lieberman , Patrick Ahles , Ned Mantei , Thomas Kelder , Samuel Sklar , Martijn Van Iersel , Egon Willighagen , Alex Pico , Bart Smeets , Daniel Riggins , Kristina Hanspers , Friederike Ehrhart , Denise Slenter , and Eric WeitzActivity
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Cited In
- Effects of the Phytochemical Combination PB123 on Nrf2 Activation, Gene Expression, and the Cholesterol Pathway in HepG2 Cells (2022).
- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
cholesterol biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| (S)-2,3-Epoxysqualene | Metabolite | chebi:15441 | |
| Mevalonic acid | Metabolite | cas:150-97-0 | |
| Farnesyl pyrophosphate | Metabolite | cas:13058-04-3 | |
| Lathosterol | Metabolite | cas:80-99-9 | |
| Lanosterin | Metabolite | cas:79-63-0 | |
| Mevalonic acid 5-pyrophosphate | Metabolite | cas:1492-08-6 | |
| 7-Dehydrocholesterol | Metabolite | cas:434-16-2 | |
| isopentenyl pyrophosphate | Metabolite | cas:358-71-4 | |
| HMG-CoA | Metabolite | hmdb:HMDB0001375 | |
| Geranyl-PP | Metabolite | cas:6699-20-3 | |
| Cholesterol | Metabolite | cas:57-88-5 | |
| Mevalonic acid-5P | Metabolite | cas:73566-35-5 | |
| Squalene | Metabolite | cas:111-02-4 | |
| Acetyl-CoA | Metabolite | cas:72-89-9 | |
| Dimethylallyl pyrophosphate | Metabolite | cas:358-72-5 | |
| NSDHL | GeneProduct | ncbigene:50814 | NAD(P) dependent steroid dehydrogenase-like |
| FDPS | GeneProduct | ncbigene:2224 | |
| HMGCS1 | GeneProduct | ncbigene:3157 | |
| SC4MOL | GeneProduct | ncbigene:6307 | |
| SQLE | GeneProduct | ncbigene:6713 | |
| IDI1 | GeneProduct | ncbigene:3422 | |
| MVD | GeneProduct | ncbigene:4597 | |
| CYP51A1 | GeneProduct | ncbigene:1595 | |
| HMGCR | GeneProduct | ncbigene:3156 | |
| DHCR7 | GeneProduct | ncbigene:1717 | |
| PMVK | GeneProduct | ncbigene:10654 | |
| SC5DL | GeneProduct | ncbigene:6309 | |
| FDFT1 | GeneProduct | ncbigene:2222 | |
| LSS | GeneProduct | ncbigene:4047 | |
| MVK | GeneProduct | ncbigene:4598 |
References
- Malformation syndromes due to inborn errors of cholesterol synthesis. Porter FD. J Clin Invest. 2002 Sep;110(6):715–24. PubMed Europe PMC Scholia