Eicosanoid metabolism via cytochrome P450 monooxygenases (WP4349)

Mus musculus

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This pathway is inspired by the LIPID MAPS Eicosanoids Pathway expended pathway display and extended with the bottom left side of Figure 1 from Dennis and Norris 2015. Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX) WP4347, lipooxygenases(LOX) WP4348, or cytochrome P450 monooxygenases (CYP) WP4349. This pathway visualises the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Authors

Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , Eric Weitz , and Kristina Hanspers

Activity

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Organisms

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism eicosanoid metabolic pathway eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma

Participants

Label Type Compact URI Comment
Arachidonic acid Metabolite lipidmaps:LMFA01030001
16-HETE Metabolite lipidmaps:LMFA03090010
17-HETE Metabolite lipidmaps:LMFA03060091
18-HETE Metabolite lipidmaps:LMFA03060092
19-HETE Metabolite lipidmaps:LMFA03060106
20-HETE Metabolite lipidmaps:LMFA03060009
5,6-EpETrE Metabolite lipidmaps:LMFA03080002
8,9-EpETrE Metabolite lipidmaps:LMFA03080003
11,12-EpETrE Metabolite lipidmaps:LMFA03090010
14,15-EpETrE Metabolite lipidmaps:LMFA03080005
5,6-DiHETrE Metabolite lipidmaps:LMFA03050004
8,9-DiHETrE Metabolite lipidmaps:LMFA03050006
11,12-DiHETrE Metabolite lipidmaps:LMFA03050008
14,15-DiHETrE Metabolite lipidmaps:LMFA03050010
Ephx2 GeneProduct ncbigene:13850
Cyp4a10 GeneProduct ncbigene:13117
Cyp4a12a GeneProduct ncbigene:277753
Cyp4a12b GeneProduct ncbigene:13118
Cyp4f14 GeneProduct ncbigene:64385
Cyp4f18 GeneProduct ncbigene:72054
PPAR gamma Protein uniprot:P37238 AKA Peroxisome proliferator-activated receptor gamma
Cyp2c29 Protein ncbigene:13095
Cyp2c37 Protein ncbigene:13096
Cyp2c38 Protein ncbigene:13097
Cyp2c39 Protein ncbigene:13098
Cyp2c40 Protein ncbigene:13099
Cyp2c44 Protein ncbigene:226143
Cyp2c54 Protein ncbigene:404195
Cyp2c55 Protein ncbigene:72082
Cyp2j5 Protein ncbigene:13109
PPAR alpha Protein uniprot:P23204 AKA Peroxisome proliferator-activated receptor alpha

References

  1. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  2. Eicosanoid storm in infection and inflammation. Dennis EA, Norris PC. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia