Glycosaminoglycan degradation (WP4815)
Homo sapiens
Taken from KEGG: Glycosaminoglycan degradation - Homo sapiens (human) [https://www.genome.jp/kegg-bin/show_pathway?hsa00531]. Some genes such as NAGZ could not be found, these have been left on the diagram as unannotated GeneProducts. Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutation in the respective gene.
Authors
Ritchie Lee , Kristina Hanspers , and Egon WillighagenActivity
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Organisms
Homo sapiensCommunities
Skeletal Dysplasia Serious Request 2024 - MetaKidsAnnotations
Pathway Ontology
classic metabolic pathway glycosaminoglycan degradation pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Dermatan sulfate | Metabolite | chebi:18376 | |
| Keratan sulfate | Metabolite | chebi:18331 | |
| hyaluronan | Metabolite | chebi:132153 | |
| (GalNAc)1 (GlcA)1 (S)1 | Metabolite | kegg.glycan:G00872 | |
| (GlcA)1 (GlcNAc)2 | Metabolite | kegg.glycan:G00711 | |
| (GlcA)2 (GlcNAc)2 | Metabolite | kegg.glycan:G00526 | |
| Heparan sulfate | Metabolite | chebi:28815 | |
| (GalNAc)2 (GlcA)1 (LIdoA)1 (S)3 | Metabolite | kegg.glycan:G13041 | |
| (GlcA)1 (GlcNAc)1 | Metabolite | kegg.glycan:G10008 | |
| (GlcA)2 (GlcN)1 (GlcNAc)1 (LIdoA)1 (S)4 | Metabolite | kegg.glycan:G13034 | |
| (GlcA)1 (GlcNAc)1 (S)1 | Metabolite | kegg.glycan:G09660 | |
| (GalNAc)2 (GlcA)1 (S)2 | Metabolite | kegg.glycan:G12336 | |
| (GalNAc)2 (GlcA)1 (LIdoA)1 (S)2 | Metabolite | kegg.glycan:G13042 | |
| (GlcA)2 (GlcN)1 (GlcNAc)1 (LIdoA)1 (S)3 | Metabolite | kegg.glycan:G13035 | |
| (GalNAc)2 (GlcA)1 (S)1 | Metabolite | kegg.glycan:G13043 | |
| (GlcA)2 (GlcNAc)1 (S)1 | Metabolite | kegg.glycan:G13040 | |
| Chondroitin sulfate | Metabolite | chebi:37397 | |
| (GlcA)2 (GlcN)1 (GlcNAc)1 (S)3 | Metabolite | kegg.glycan:G13036 | |
| (GlcA)2 (GlcN)1 (GlcNAc)1 (S)2 | Metabolite | kegg.glycan:G13037 | |
| (GlcA)2 (GlcNAc)2 (S)2 | Metabolite | kegg.glycan:G13038 | |
| (GlcA)2 (GlcNAc)1 (S)2 | Metabolite | kegg.glycan:G13039 | |
| (GlcA)1 (GlcNAc)1 | Metabolite | kegg.glycan:G02632 | |
| (Gal)2 (GlcNAc)2 (S)3 | Metabolite | kegg.glycan:G01945 | |
| (Gal)2 (GlcNAc)2 (S)2 | Metabolite | kegg.glycan:G01977 | |
| (Gal)1 (GlcNAc)2 (S)2 | Metabolite | kegg.glycan:G13073 | |
| (Gal)1 (GlcNAc)2 (S)1 | Metabolite | kegg.glycan:G13074 | |
| (Gal)1 (GlcNAc)1 (S)1 | Metabolite | kegg.glycan:G01391 | |
| GNS | GeneProduct | ensembl:ENSG00000135677 | |
| HPSE | GeneProduct | ensembl:ENSG00000173083 | |
| GUSB | GeneProduct | ensembl:ENSG00000169919 | |
| ARSB | GeneProduct | ensembl:ENSG00000113273 | |
| IDUA | GeneProduct | ensembl:ENSG00000127415 | |
| HEXA | GeneProduct | ensembl:ENSG00000213614 | |
| HYAL2 | GeneProduct | ensembl:ENSG00000068001 | |
| SGSH | GeneProduct | ensembl:ENSG00000181523 | |
| IDS | GeneProduct | ensembl:ENSG00000010404 | |
| GALNS | GeneProduct | ensembl:ENSG00000141012 | |
| HPSE2 | GeneProduct | ensembl:ENSG00000172987 | |
| HYAL4 | GeneProduct | ensembl:ENSG00000106302 | |
| GLB1 | GeneProduct | ensembl:ENSG00000170266 | |
| HYAL1 | GeneProduct | ensembl:ENSG00000114378 | |
| HGSNAT | GeneProduct | ensembl:ENSG00000165102 | |
| NAGLU | GeneProduct | ensembl:ENSG00000108784 | |
| HEXB | GeneProduct | ensembl:ENSG00000049860 |
References
- KEGG Pathway: hsa00531
- Drugs affecting glycosaminoglycan metabolism. Ghiselli G, Maccarana M. Drug Discov Today. 2016 Jul;21(7):1162–9. PubMed Europe PMC Scholia