Tryptophan metabolism (WP79)

Mus musculus

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This pathway describes the metabolism of tryptophan, an essential amino acid. Originally converted from rat to human using ortholog information. Edited by Sebastien Burel

Authors

Lynn M. Ferrante , Kristina Hanspers , Egon Willighagen , Daniela Digles , Alex Pico , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

tryptophan metabolic pathway

Participants

Label Type Compact URI Comment
4-(2-Aminophenyl)-2,4-dioxobutanoate Metabolite chebi:58147 4-(2-Aminophenyl)-2,4-dioxobutanoate
Indolelactate Metabolite pubchem.compound:92904 Indolelactate
2-Aminomuconate Metabolite chemspider:27 2-Aminomuconate
3-Methylindolepyruvate Metabolite pubchem.compound:440740 3-Methylindolepyruvate
7,8-Dihydro-7,8-dihydroxykynurenate Metabolite chemspider:388563 7,8-Dihydro-7,8-dihydroxykynurenate
Indole-3-acetate Metabolite chemspider:780 Indole-3-acetate
N-Methylserotonin Metabolite pubchem.compound:150885 N-Methylserotonin
C00877 Metabolite kegg.compound:C00877 Crotonoyl-CoA
N-Methyltryptamine Metabolite chebi:28136 N-Methyltryptamine
4,8-Dihydroxyquinoline Metabolite chebi:28883 4,8-Dihydroxyquinoline
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate Metabolite chemspider:389617 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
Oxaloacetate Metabolite chebi:16452 Oxaloacetate
3-(2-Aminoethyl)-1H-indol-5-ol Metabolite pubchem.compound:5202 3-(2-Aminoethyl)-1H-indol-5-ol
Indolepyruvate Metabolite pubchem.compound:803 Indolepyruvate
Melatonin Metabolite pubchem.compound:896
Indole-3-acetaldehyde Metabolite chebi:18086 Indole-3-acetaldehyde
Glucobrassicin Metabolite chebi:29028 Glucobrassicin
Kynurenate Metabolite chebi:18344 4-Hydroxy-2-quinolinecarboxylic
C00527 Metabolite kegg.compound:C00527 Glutaryl-CoA
Formylanthranilate Metabolite chebi:18410 Formylanthranilate
3-Hydroxy-L-kynurenine Metabolite chebi:17380 3-Hydroxy-L-kynurenine
5-Methoxyindoleacetate Metabolite pubchem.compound:18986 5-Methoxyindoleacetate
3-Methyldioxyindole Metabolite chebi:28254
C01144 Metabolite kegg.compound:C01144 (S)-3-Hydroxybutanoyl-CoA
5-Hydroxyindoleacetaldehyde Metabolite pubchem.compound:74688 5-Hydroxyindoleacetaldehyde
3-Hydroxyanthranilate Metabolite chemspider:7822291 3-Hydroxyanthranilate
Indole-3-acetaldoxime Metabolite chebi:28311 Indole-3-acetaldoxime
5-Hydroxy-N-formylkynurenine Metabolite chemspider:389615 5-Hydroxy-N-formylkynurenine
Isophenoxazine Metabolite chemspider:65565 Isophenoxazine
5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate Metabolite chemspider:389619 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
Indole-3-ethanol Metabolite pubchem.compound:10685
6-Hydroxyindolelactate Metabolite chebi:27524 6-Hydroxyindolelactate
Anthranilate Metabolite chebi:16567 Anthranilate
5-Hydroxykynurenamine Metabolite chemspider:144400 5-Hydroxykynurenamine
2-Formylaminobenzaldehyde Metabolite chebi:18033
4,6-Dihydroxyquinoline Metabolite chemspider:389609 4,6-Dihydroxyquinoline
2,3-Dihydroxyindole Metabolite chebi:17828
Quinolinate Metabolite chemspider:2777129
Cinnavalininate Metabolite chemspider:102864 Cinnavalininate
5-Hydroxy-L-tryptophan Metabolite chebi:17780 5-Hydroxy-L-tryptophan
3-Hydroxykynurenamine Metabolite chemspider:144400 3-Hydroxykynurenamine
Formyl-5-hydroxykynurenamine Metabolite pubchem.compound:440743
5-Hydroxyindolepyruvate Metabolite chemspider:389613
3-Methoxyanthranilate Metabolite chebi:20109 3-Methoxyanthranilate
2-Oxoglutarate Metabolite chebi:30916 2-Oxoglutarate
N-Acetylindoxyl Metabolite chebi:15363 N-Acetylindoxyl
2-Oxoadipate Metabolite chemspider:70 2-Oxoadipate
7,8-Dihydroxykynurenate Metabolite chebi:58171 7,8-Dihydroxykynurenate
Xanthurenic Metabolite chemspider:5497 Xanthurenic
5-Hydroxyindoleacetate Metabolite pubchem.compound:1826 5-Hydroxyindoleacetate
C00332 Metabolite kegg.compound:C00332 Acetoacetyl-CoA
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate Metabolite chemspider:389620 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
(Z)-5-Oxohex-2-enedioate Metabolite chebi:16967 (Z)-5-Oxohex-2-enedioate
5-(2'-Formylethyl)-4,6-dihydroxypicolinate Metabolite chemspider:389618 5-(2'-Formylethyl)-4,6-dihydroxypicolinate
Formyl-N-acetyl-5-methoxykynurenamine Metabolite pubchem.compound:171161 Formyl-N-acetyl-5-methoxykynurenamine
3-Indoleglycolaldehyde Metabolite chebi:15976
8-Methoxykynurenate Metabolite chebi:20109 8-Methoxykynurenate
6-Hydroxykynurenate Metabolite chemspider:389622 6-Hydroxykynurenate
5-Hydroxyindoleacetylglycine Metabolite pubchem.compound:440806
Formylkynurenine Metabolite chebi:30249 Formylkynurenine
Acetyl-CoA Metabolite chebi:15351 Acetyl-CoA
Indole Metabolite pubchem.compound:798
5-Methoxytryptamine Metabolite chebi:2089
L-Kynurenine Metabolite chebi:16946 L-Kynurenine
5-Hydroxykynurenine Metabolite chemspider:389616
Tryptamine Metabolite chebi:16765
N-Acetylisatin Metabolite chebi:16050 N-Acetylisatin
L-Tryptophan Metabolite pubchem.compound:6305
Indole-3-acetamide Metabolite chebi:16031 Indole-3-acetamide
3-Indoleacetonitrile Metabolite chebi:17566 3-Indoleacetonitrile
2-Aminophenol Metabolite chebi:18112 2-Aminophenol
6-Hydroxymelatonin Metabolite pubchem.compound:1864
N-Acetylserotonin Metabolite chebi:17697 N-Acetylserotonin
Cyp4f14 GeneProduct ncbigene:64385
Ubr5 GeneProduct ncbigene:70790
Ido1 GeneProduct ncbigene:15930
Cyp2e1 GeneProduct ncbigene:13106
Rnf25 GeneProduct ncbigene:57751
Gcdh GeneProduct ncbigene:270076 predicted
Aldh9a1 GeneProduct ncbigene:56752
Prmt1 GeneProduct ncbigene:15469
Aldh2 GeneProduct ncbigene:11669
Aldh1a2 GeneProduct ncbigene:19378
ASMT GeneProduct ncbigene:107626
Cyp1a1 GeneProduct ncbigene:13076
Mdm2 GeneProduct ncbigene:17246
Ogdh GeneProduct ncbigene:18293
Maob GeneProduct ncbigene:109731
Aldh3a2 GeneProduct ncbigene:11671
Ddc GeneProduct ncbigene:13195
Hsd17b10 GeneProduct ncbigene:15108
Cat GeneProduct ncbigene:12359
Ube3a GeneProduct ncbigene:22215
Hadh GeneProduct ncbigene:15107
Cyp7b1 GeneProduct ncbigene:13123
Aadat GeneProduct ncbigene:23923
Acat1 GeneProduct ncbigene:110446
Kynu GeneProduct ncbigene:70789
Afmid GeneProduct ncbigene:71562
Cyp1b1 GeneProduct ncbigene:13078
Aanat GeneProduct ncbigene:11298
Aox1 GeneProduct ncbigene:11761
Dhcr24 GeneProduct ncbigene:74754 predicted
Acmsd GeneProduct ncbigene:266645
Cyp1a2 GeneProduct ncbigene:13077
Cyp2c55 GeneProduct ncbigene:72082
Wars GeneProduct ncbigene:22375
Inmt GeneProduct ncbigene:21743
Cyp19a1 GeneProduct ncbigene:13075
Aldh1a1 GeneProduct ncbigene:11668
Cyp2j6 GeneProduct ncbigene:13110
Haao GeneProduct ncbigene:107766
Abp1 GeneProduct ncbigene:76507
Echs1 GeneProduct ncbigene:93747
Tdo2 GeneProduct ncbigene:56720
Cyp2f2 GeneProduct ncbigene:13107
Tph1 GeneProduct ncbigene:21990

References