Tryptophan metabolism (WP79)
Mus musculus
This pathway describes the metabolism of tryptophan, an essential amino acid. Originally converted from rat to human using ortholog information. Edited by Sebastien Burel
Authors
Lynn M. Ferrante , Kristina Hanspers , Egon Willighagen , Daniela Digles , Alex Pico , Friederike Ehrhart , and Eric WeitzActivity
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Cited In
- Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia (2020).
- Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats (2016).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
tryptophan metabolic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
4-(2-Aminophenyl)-2,4-dioxobutanoate | Metabolite | chebi:58147 | 4-(2-Aminophenyl)-2,4-dioxobutanoate |
Indolelactate | Metabolite | pubchem.compound:92904 | Indolelactate |
2-Aminomuconate | Metabolite | chemspider:27 | 2-Aminomuconate |
3-Methylindolepyruvate | Metabolite | pubchem.compound:440740 | 3-Methylindolepyruvate |
7,8-Dihydro-7,8-dihydroxykynurenate | Metabolite | chemspider:388563 | 7,8-Dihydro-7,8-dihydroxykynurenate |
Indole-3-acetate | Metabolite | chemspider:780 | Indole-3-acetate |
N-Methylserotonin | Metabolite | pubchem.compound:150885 | N-Methylserotonin |
C00877 | Metabolite | kegg.compound:C00877 | Crotonoyl-CoA |
N-Methyltryptamine | Metabolite | chebi:28136 | N-Methyltryptamine |
4,8-Dihydroxyquinoline | Metabolite | chebi:28883 | 4,8-Dihydroxyquinoline |
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate | Metabolite | chemspider:389617 | 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate |
Oxaloacetate | Metabolite | chebi:16452 | Oxaloacetate |
3-(2-Aminoethyl)-1H-indol-5-ol | Metabolite | pubchem.compound:5202 | 3-(2-Aminoethyl)-1H-indol-5-ol |
Indolepyruvate | Metabolite | pubchem.compound:803 | Indolepyruvate |
Melatonin | Metabolite | pubchem.compound:896 | |
Indole-3-acetaldehyde | Metabolite | chebi:18086 | Indole-3-acetaldehyde |
Glucobrassicin | Metabolite | chebi:29028 | Glucobrassicin |
Kynurenate | Metabolite | chebi:18344 | 4-Hydroxy-2-quinolinecarboxylic |
C00527 | Metabolite | kegg.compound:C00527 | Glutaryl-CoA |
Formylanthranilate | Metabolite | chebi:18410 | Formylanthranilate |
3-Hydroxy-L-kynurenine | Metabolite | chebi:17380 | 3-Hydroxy-L-kynurenine |
5-Methoxyindoleacetate | Metabolite | pubchem.compound:18986 | 5-Methoxyindoleacetate |
3-Methyldioxyindole | Metabolite | chebi:28254 | |
2-Aminomuconate | Metabolite | chemspider:27 | 2-Aminomuconate |
C01144 | Metabolite | kegg.compound:C01144 | (S)-3-Hydroxybutanoyl-CoA |
5-Hydroxyindoleacetaldehyde | Metabolite | pubchem.compound:74688 | 5-Hydroxyindoleacetaldehyde |
3-Hydroxyanthranilate | Metabolite | chemspider:7822291 | 3-Hydroxyanthranilate |
Indole-3-acetaldoxime | Metabolite | chebi:28311 | Indole-3-acetaldoxime |
5-Hydroxy-N-formylkynurenine | Metabolite | chemspider:389615 | 5-Hydroxy-N-formylkynurenine |
Isophenoxazine | Metabolite | chemspider:65565 | Isophenoxazine |
5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate | Metabolite | chemspider:389619 | 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate |
Indole-3-ethanol | Metabolite | pubchem.compound:10685 | |
6-Hydroxyindolelactate | Metabolite | chebi:27524 | 6-Hydroxyindolelactate |
Anthranilate | Metabolite | chebi:16567 | Anthranilate |
5-Hydroxykynurenamine | Metabolite | chemspider:144400 | 5-Hydroxykynurenamine |
Anthranilate | Metabolite | chebi:16567 | Anthranilate |
2-Formylaminobenzaldehyde | Metabolite | chebi:18033 | |
4,6-Dihydroxyquinoline | Metabolite | chemspider:389609 | 4,6-Dihydroxyquinoline |
2,3-Dihydroxyindole | Metabolite | chebi:17828 | |
Quinolinate | Metabolite | chemspider:2777129 | |
Cinnavalininate | Metabolite | chemspider:102864 | Cinnavalininate |
5-Hydroxy-L-tryptophan | Metabolite | chebi:17780 | 5-Hydroxy-L-tryptophan |
3-Hydroxykynurenamine | Metabolite | chemspider:144400 | 3-Hydroxykynurenamine |
Formyl-5-hydroxykynurenamine | Metabolite | pubchem.compound:440743 | |
5-Hydroxyindolepyruvate | Metabolite | chemspider:389613 | |
3-Methoxyanthranilate | Metabolite | chebi:20109 | 3-Methoxyanthranilate |
2-Oxoglutarate | Metabolite | chebi:30916 | 2-Oxoglutarate |
N-Acetylindoxyl | Metabolite | chebi:15363 | N-Acetylindoxyl |
2-Oxoadipate | Metabolite | chemspider:70 | 2-Oxoadipate |
7,8-Dihydroxykynurenate | Metabolite | chebi:58171 | 7,8-Dihydroxykynurenate |
Xanthurenic | Metabolite | chemspider:5497 | Xanthurenic |
5-Hydroxyindoleacetate | Metabolite | pubchem.compound:1826 | 5-Hydroxyindoleacetate |
C00332 | Metabolite | kegg.compound:C00332 | Acetoacetyl-CoA |
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate | Metabolite | chemspider:389620 | 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate |
(Z)-5-Oxohex-2-enedioate | Metabolite | chebi:16967 | (Z)-5-Oxohex-2-enedioate |
5-(2'-Formylethyl)-4,6-dihydroxypicolinate | Metabolite | chemspider:389618 | 5-(2'-Formylethyl)-4,6-dihydroxypicolinate |
Formyl-N-acetyl-5-methoxykynurenamine | Metabolite | pubchem.compound:171161 | Formyl-N-acetyl-5-methoxykynurenamine |
3-Indoleglycolaldehyde | Metabolite | chebi:15976 | |
8-Methoxykynurenate | Metabolite | chebi:20109 | 8-Methoxykynurenate |
6-Hydroxykynurenate | Metabolite | chemspider:389622 | 6-Hydroxykynurenate |
5-Hydroxyindoleacetylglycine | Metabolite | pubchem.compound:440806 | |
Formylkynurenine | Metabolite | chebi:30249 | Formylkynurenine |
Acetyl-CoA | Metabolite | chebi:15351 | Acetyl-CoA |
Indole | Metabolite | pubchem.compound:798 | |
5-Methoxytryptamine | Metabolite | chebi:2089 | |
L-Kynurenine | Metabolite | chebi:16946 | L-Kynurenine |
5-Hydroxykynurenine | Metabolite | chemspider:389616 | |
Tryptamine | Metabolite | chebi:16765 | |
N-Acetylisatin | Metabolite | chebi:16050 | N-Acetylisatin |
L-Tryptophan | Metabolite | pubchem.compound:6305 | |
Indole-3-acetamide | Metabolite | chebi:16031 | Indole-3-acetamide |
3-Indoleacetonitrile | Metabolite | chebi:17566 | 3-Indoleacetonitrile |
2-Aminophenol | Metabolite | chebi:18112 | 2-Aminophenol |
6-Hydroxymelatonin | Metabolite | pubchem.compound:1864 | |
N-Acetylserotonin | Metabolite | chebi:17697 | N-Acetylserotonin |
Cyp4f14 | GeneProduct | ncbigene:64385 | |
Ubr5 | GeneProduct | ncbigene:70790 | |
Ido1 | GeneProduct | ncbigene:15930 | |
Cyp2e1 | GeneProduct | ncbigene:13106 | |
Rnf25 | GeneProduct | ncbigene:57751 | |
Gcdh | GeneProduct | ncbigene:270076 | predicted |
Aldh9a1 | GeneProduct | ncbigene:56752 | |
Prmt1 | GeneProduct | ncbigene:15469 | |
Aldh2 | GeneProduct | ncbigene:11669 | |
Aldh1a2 | GeneProduct | ncbigene:19378 | |
ASMT | GeneProduct | ncbigene:107626 | |
Cyp1a1 | GeneProduct | ncbigene:13076 | |
Mdm2 | GeneProduct | ncbigene:17246 | |
Ogdh | GeneProduct | ncbigene:18293 | |
Maob | GeneProduct | ncbigene:109731 | |
Aldh3a2 | GeneProduct | ncbigene:11671 | |
Maob | GeneProduct | ncbigene:109731 | |
Ddc | GeneProduct | ncbigene:13195 | |
Hsd17b10 | GeneProduct | ncbigene:15108 | |
Aldh9a1 | GeneProduct | ncbigene:56752 | |
Cat | GeneProduct | ncbigene:12359 | |
Ube3a | GeneProduct | ncbigene:22215 | |
Hadh | GeneProduct | ncbigene:15107 | |
Aldh3a2 | GeneProduct | ncbigene:11671 | |
Ddc | GeneProduct | ncbigene:13195 | |
Ddc | GeneProduct | ncbigene:13195 | |
Aldh2 | GeneProduct | ncbigene:11669 | |
Maob | GeneProduct | ncbigene:109731 | |
Mdm2 | GeneProduct | ncbigene:17246 | |
Cyp7b1 | GeneProduct | ncbigene:13123 | |
Ube3a | GeneProduct | ncbigene:22215 | |
Aadat | GeneProduct | ncbigene:23923 | |
Acat1 | GeneProduct | ncbigene:110446 | |
Ido1 | GeneProduct | ncbigene:15930 | |
Aldh1a2 | GeneProduct | ncbigene:19378 | |
Kynu | GeneProduct | ncbigene:70789 | |
Afmid | GeneProduct | ncbigene:71562 | |
Cyp1b1 | GeneProduct | ncbigene:13078 | |
Aanat | GeneProduct | ncbigene:11298 | |
Aox1 | GeneProduct | ncbigene:11761 | |
Dhcr24 | GeneProduct | ncbigene:74754 | predicted |
Aadat | GeneProduct | ncbigene:23923 | |
Acmsd | GeneProduct | ncbigene:266645 | |
Ido1 | GeneProduct | ncbigene:15930 | |
Kynu | GeneProduct | ncbigene:70789 | |
Cyp1a2 | GeneProduct | ncbigene:13077 | |
Cyp2c55 | GeneProduct | ncbigene:72082 | |
Wars | GeneProduct | ncbigene:22375 | |
Inmt | GeneProduct | ncbigene:21743 | |
Cyp19a1 | GeneProduct | ncbigene:13075 | |
Prmt1 | GeneProduct | ncbigene:15469 | |
Aldh1a1 | GeneProduct | ncbigene:11668 | |
Cyp2j6 | GeneProduct | ncbigene:13110 | |
Haao | GeneProduct | ncbigene:107766 | |
Prmt1 | GeneProduct | ncbigene:15469 | |
Abp1 | GeneProduct | ncbigene:76507 | |
Rnf25 | GeneProduct | ncbigene:57751 | |
Maob | GeneProduct | ncbigene:109731 | |
Kynu | GeneProduct | ncbigene:70789 | |
Mdm2 | GeneProduct | ncbigene:17246 | |
Echs1 | GeneProduct | ncbigene:93747 | |
Tdo2 | GeneProduct | ncbigene:56720 | |
Cyp2f2 | GeneProduct | ncbigene:13107 | |
Gcdh | GeneProduct | ncbigene:270076 | predicted |
Tph1 | GeneProduct | ncbigene:21990 | |
Aldh1a1 | GeneProduct | ncbigene:11668 | |
ASMT | GeneProduct | ncbigene:107626 |