Salvage pathways of pyrimidine deoxyribonucleotides (WP220)

Saccharomyces cerevisiae

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
The deoxynucleotides required for DNA synthesis can either be made de novo, or they can be salvaged from endogenous degradation processes. If the required substrates are available, the salvage pathways of pyrimidine deoxyribonucleotides are preferred over de novo synthesis pathways for pyrimidine biosynthesis. As with many of the metabolic pathways of S. cerevisiae, the pathways for the salvage of pyrimidine deoxyribonucleotides are regulated by a variety of processes, including transcription regulation. Description adapted from YeastPathways (https://pathway.yeastgenome.org/)

Authors

Meredith Braymer , Egon Willighagen , Linda Rieswijk , Eric Weitz , and Kristina Hanspers

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

nucleotide metabolic pathway classic metabolic pathway

Participants

Label Type Compact URI Comment
uracil Metabolite cas:66-22-8
thymidine Metabolite cas:50-89-5
phosphate Metabolite cas:14265-44-2
thymine Metabolite cas:65-71-4
Deoxyuridine Metabolite cas:951-78-0
H2O Metabolite chebi:15377
2'-deoxycytidine Metabolite chebi:15698
H+ Metabolite chebi:15378
NH3 Metabolite chebi:28938
dUMP Metabolite chebi:246422
2-deoxy-α-D-ribose 1-phosphate Metabolite chebi:57259
dTMP Metabolite chebi:63528
ATP Metabolite cas:1927-31-7
ADP Metabolite cas:58-64-0
Cytosine Metabolite chebi:16040
2'-deoxyribose Metabolite chebi:131350
cCMP Metabolite chebi:57566
CDD1 GeneProduct sgd:S000004235
URH1 GeneProduct sgd:S000002808
URK1 GeneProduct sgd:S000005295
2.4.2.2 GeneProduct eccode:2.4.2.2
2.4.2.3 GeneProduct eccode:2.4.2.3
2.7.1.21 GeneProduct eccode:2.7.1.21
2.7.1.145 GeneProduct eccode:2.7.1.145
2.4.2.4 GeneProduct eccode:2.4.2.4

References

  1. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=YEAST-SALV-PYRMID-DNTP