p38 Mapk signaling pathway (WP294)

Rattus norvegicus

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Authors

Sebastien Burel , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

p38 MAPK signaling pathway

Participants

Label Type Compact URI Comment
Mapkapk2 GeneProduct ensembl:ENSRNOG00000004726 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9261
Grb2 GeneProduct ensembl:ENSRNOG00000003990 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2885
Traf2 GeneProduct ensembl:ENSRNOG00000006238 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7186
Mapkapk5 GeneProduct ensembl:ENSRNOG00000001345 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8550
Hspb1 GeneProduct ensembl:ENSRNOG00000023546 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3315
Shc1 GeneProduct ensembl:ENSRNOG00000020657 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6464
Map2k6 GeneProduct ensembl:ENSRNOG00000004437 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5608
Map3k9 GeneProduct ensembl:ENSRNOG00000007271 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4293
Rac1 GeneProduct ensembl:ENSRNOG00000001068 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5879
Tgfbr1 GeneProduct ensembl:ENSRNOG00000007036 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7046
Mef2d GeneProduct ensembl:ENSRNOG00000031778 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4209
Atf2 GeneProduct ensembl:ENSRNOG00000001597 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1386
Stat1 GeneProduct ensembl:ENSRNOG00000014079 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6772
Creb1 GeneProduct ensembl:ENSRNOG00000013412 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1385
Map3k5 GeneProduct ensembl:ENSRNOG00000031700 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4217
Mknk1 GeneProduct ensembl:ENSRNOG00000010381 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8569
LOC100910771 GeneProduct ensembl:ENSRNOG00000005724 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6885
Ripk1 GeneProduct ensembl:ENSRNOG00000017787 receptor (TNFRSF)-interacting serine-threonine kinase 1
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8737
Rps6ka5 GeneProduct ensembl:ENSRNOG00000004362 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9252
Mapk14 GeneProduct ensembl:ENSRNOG00000000513 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1432
Elk1 GeneProduct ensembl:ENSRNOG00000010171 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2002
Max GeneProduct ensembl:ENSRNOG00000008049 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4149
Hras GeneProduct ensembl:ENSRNOG00000016611 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3265
Cdc42 GeneProduct ensembl:ENSRNOG00000013536 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:998
LOC100911295 GeneProduct ensembl:ENSRNOG00000050978 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3150
Pla2g4a GeneProduct ensembl:ENSRNOG00000002657 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5321
Map2k4 GeneProduct ensembl:ENSRNOG00000003834 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6416
Ddit3 GeneProduct ensembl:ENSRNOG00000006789 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1649
Rasgrf1 GeneProduct ensembl:ENSRNOG00000014025 PDZ domain containing guanine nucleotide exchange
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5923
Tgfb2 GeneProduct ensembl:ENSRNOG00000002418 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7042
Daxx GeneProduct ensembl:ENSRNOG00000000477 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1616
LOC100912399 GeneProduct ensembl:ENSRNOG00000013177 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4214
Myc GeneProduct ensembl:ENSRNOG00000004500 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609
Tradd GeneProduct ensembl:ENSRNOG00000015179 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8717

References

  1. Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone. Roberson MS, Zhang T, Li HL, Mulvaney JM. Endocrinology. 1999 Mar;140(3):1310–8. PubMed Europe PMC Scholia
  2. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3763–8. PubMed Europe PMC Scholia
  3. Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses. Kyriakis JM. Biochem Soc Symp. 1999;64:29–48. PubMed Europe PMC Scholia
  4. The stress-activated protein kinase pathways. Tibbles LA, Woodgett JR. Cell Mol Life Sci. 1999 Aug 15;55(10):1230–54. PubMed Europe PMC Scholia
  5. p38 MAPK signalling cascades in inflammatory disease. Herlaar E, Brown Z. Mol Med Today. 1999 Oct;5(10):439–47. PubMed Europe PMC Scholia
  6. Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin. Li S, Wattenberg EV. Toxicol Appl Pharmacol. 1999 Oct 15;160(2):109–19. PubMed Europe PMC Scholia
  7. From receptors to stress-activated MAP kinases. Ichijo H. Oncogene. 1999 Nov 1;18(45):6087–93. PubMed Europe PMC Scholia
  8. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, et al. Mol Cell. 2000 Dec;6(6):1343–54. PubMed Europe PMC Scholia