Major receptors targeted by epinephrine and norepinephrine (WP4589)
Homo sapiens
The physiologic "fear" response is associated with the signaling activity of adrenergic receptors stimulated by epinephrine/norepinephrine.
Authors
Chris Gillissen , Egon Willighagen , Friederike Ehrhart , Denise Slenter , Alex Pico , Kristina Hanspers , and Finterly HuActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract (2021).
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
norepinephrine signaling pathway epinephrine signaling pathway classic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| calcium | Metabolite | chebi:29108 | |
| ATP | Metabolite | chebi:30616 | |
| Epinephrine | Metabolite | wikidata:Q132621 | AKA adrenaline |
| Serine | Metabolite | chebi:17115 | |
| DAG | Metabolite | wikidata:Q161466 | diacylglycerol |
| pyro-phosphate | Metabolite | chebi:33019 | |
| cAMP | Metabolite | chebi:58165 | |
| Threonine | Metabolite | chebi:57926 | |
| Serine | Metabolite | chebi:17115 | |
| Threonine | Metabolite | chebi:57926 | |
| β2 receptor | Protein | uniprot:P07550 | G protein–coupled receptor (GPCR) |
| β1 receptor | Protein | uniprot:P08588 | G protein–coupled receptor (GPCR) |
| PKC | Protein | eccode:2.7.11.13 | Protein Kinase C |
| α1A receptor | Protein | uniprot:P3548 | |
| α2A receptor | Protein | uniprot:P08913 | |
| PKA | Protein | eccode:2.7.11.11 | Protein Kinase A |
| ADCY1 | Protein | uniprot:Q08828 | |
| AC | Protein | eccode:4.6.1.1 | |
| α1B receptor | Protein | uniprot:P3568 | |
| α1D receptor | Protein | uniprot:P25100 | |
| α2B receptor | Protein | uniprot:P18089 | |
| α2C receptor | Protein | uniprot:P18825 | |
| AC | Protein | eccode:4.6.1.1 | |
| AC | Protein | eccode:4.6.1.1 | 'There are ten known isoforms of adenylyl cyclases in mammals' [https://en.wikipedia.org/wiki/Adenylyl_cyclase] |
| ADCY2 | Protein | uniprot:Q08462 | |
| ADCY3 | Protein | uniprot:O60266 | |
| ADCY4 | Protein | uniprot:Q8NFM4 | |
| ADCY5 | Protein | uniprot:O95622 | |
| ADCY6 | Protein | uniprot:O43306 | |
| ADCY7 | Protein | uniprot:P51828 | |
| ADCY8 | Protein | uniprot:P40145 | |
| ADCY9 | Protein | uniprot:O60503 | |
| ADCY10 | Protein | uniprot:Q96PN6 |
References
- The Fats of Life [Internet]. Lawrence GD. 2010. 277 p. Available from: https://books.google.com/books/about/The_Fats_of_Life.html?hl=&id=_67cmAEACAAJ OpenLibrary Worldcat