Ethanol metabolism production of ROS by CYP2E1 (WP4269)
Homo sapiens
Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for rat and mouse.
Authors
Ado , Egon Willighagen , Marvin Martens , Friederike Ehrhart , and Eric WeitzActivity
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Cited In
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- Identification of high‐dimensional omics‐derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling (2021).
- Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Staurosporine | Metabolite | chebi:57491 | |
| Acetaldehyde | Metabolite | chebi:15343 | |
| Ethanol | Metabolite | chebi:16236 | |
| Vitamin C | Metabolite | chebi:38290 | |
| Diallyl sulfide | Metabolite | chebi:4489 | |
| U0126 | Metabolite | chebi:90693 | |
| Fluoride | Metabolite | chebi:17051 | |
| Enflurane | Metabolite | hmdb:HMDB0014373 | |
| Halothane | Metabolite | chebi:5615 | |
| Sevoflurane | Metabolite | chebi:9130 | |
| 6-Hydroxychlorzoxazone | Metabolite | hmdb:HMDB0060998 | |
| Isoflurane | Metabolite | chebi:6015 | |
| NAPQI | Metabolite | chebi:29132 | |
| Methoxyflurane | Metabolite | chebi:6843 | |
| Acetaminophen | Metabolite | chebi:46195 | |
| Chlorzoxazone | Metabolite | chebi:3655 | |
| Trifluoroacetic acid | Metabolite | chebi:45892 | |
| MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
| CYP2E1 | GeneProduct | ensembl:ENSG00000130649 | |
| SP1 | GeneProduct | ensembl:ENSG00000185591 | |
| MAP2K2 | GeneProduct | ensembl:ENSG00000126934 | |
| MAFF | GeneProduct | ensembl:ENSG00000185022 | |
| MAFG | GeneProduct | ensembl:ENSG00000197063 | |
| MAP2K1 | GeneProduct | ensembl:ENSG00000169032 | |
| MAFK | GeneProduct | ensembl:ENSG00000198517 | |
| NFE2L2 | GeneProduct | ensembl:ENSG00000116044 | |
| Protein kinase C | Protein | uniprot:A0A087X0I9 |
References
- Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M, Ande A, Kumar A, Kumar S. Cell Death Dis. 2013 Mar 21;4(3):e554. PubMed Europe PMC Scholia