Butyrate-induced histone acetylation (WP2366)

Homo sapiens

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Metabolism of butyrate is suggested to be an energy source for histone acetylation.

Authors

Egon Willighagen , Martina Summer-Kutmon , Anders Riutta , and Denise Slenter

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Butyrate Metabolite chebi:17968
Citrate Metabolite chebi:35808
Acetyl CoA Metabolite chebi:15351
Glucose Metabolite chebi:17634
AKT Protein uniprot:P31749
ACL Protein uniprot:P53396
HDACs Protein interpro:IPR000286

References

  1. Inhibition of histone deacetylase activity by butyrate. Davie JR. J Nutr. 2003 Jul;133(7 Suppl):2485S-2493S. PubMed Europe PMC Scholia
  2. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ. Mol Cell. 2012 Nov 30;48(4):612–26. PubMed Europe PMC Scholia