Toll-like receptor signaling pathway (WP1309)
Rattus norvegicus
Authors
Daniela Digles and Egon WillighagenActivity
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Cited In
- Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air (2020).
- Prophylactic therapy with human amniotic fluid stem cells improved survival in a rat model of lipopolysaccharide-induced neonatal sepsis through immunomodulation via aggregates with peritoneal macrophages (2020).
- Microarray analyses reveal novel targets of exercise-induced stress resistance in the dorsal raphe nucleus (2013).
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
Toll-like receptor signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Imidazoquinolin | Metabolite | chemspider:14697812 | |
Ifnb1 | GeneProduct | ncbigene:24481 | Original kegg element: gene;1;hsa:3456 |
Chuk | GeneProduct | ncbigene:309361 | Original kegg element: gene;2;hsa:1147 |
Traf6 | GeneProduct | ncbigene:311245 | Original kegg element: gene;3;hsa:7189 |
Irak1 | GeneProduct | ncbigene:363520 | Original kegg element: gene;4;hsa:3654 |
Irak4 | GeneProduct | ncbigene:300177 | Original kegg element: gene;5;hsa:51135 |
Myd88 | GeneProduct | ncbigene:301059 | Original kegg element: gene;6;hsa:4615 |
Myd88 | GeneProduct | ncbigene:301059 | Original kegg element: gene;7;hsa:4615 |
Myd88 | GeneProduct | ncbigene:301059 | Original kegg element: gene;8;hsa:4615 |
Traf6 | GeneProduct | ncbigene:311245 | Original kegg element: gene;9;hsa:7189 |
Nfkb1 | GeneProduct | ncbigene:81736 | Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970 |
Nfkb2 | GeneProduct | ncbigene:309452 | Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970 |
Rela | GeneProduct | ncbigene:309165 | Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970 |
Mapk1 | GeneProduct | ncbigene:116590 | Original kegg element: gene;11;hsa:5594 hsa:5595 |
Mapk3 | GeneProduct | ncbigene:50689 | Original kegg element: gene;11;hsa:5594 hsa:5595 |
Map2k1 | GeneProduct | ncbigene:170851 | Original kegg element: gene;12;hsa:5604 hsa:5605 |
Map2k2 | GeneProduct | ncbigene:58960 | Original kegg element: gene;12;hsa:5604 hsa:5605 |
Map3k8 | GeneProduct | ncbigene:116596 | Original kegg element: gene;13;hsa:1326 |
Nfkb1 | GeneProduct | ncbigene:81736 | Original kegg element: gene;14;hsa:4790 |
Spp1 | GeneProduct | ncbigene:25353 | Original kegg element: gene;15;hsa:6696 |
Traf3 | GeneProduct | ncbigene:362788 | Original kegg element: gene;16;hsa:7187 |
Ripk1 | GeneProduct | ncbigene:306886 | Original kegg element: gene;17;hsa:8737 |
Irf7 | GeneProduct | ncbigene:293624 | Original kegg element: gene;20;hsa:3665 |
Irf5 | GeneProduct | ncbigene:296953 | Original kegg element: gene;21;hsa:3663 |
Cxcl11 | GeneProduct | ncbigene:305236 | Original kegg element: gene;23;hsa:6373 |
Cxcl9 | GeneProduct | ncbigene:246759 | Original kegg element: gene;24;hsa:4283 |
Cxcl10 | GeneProduct | ncbigene:245920 | Original kegg element: gene;25;hsa:3627 |
Ifnb1 | GeneProduct | ncbigene:24481 | Original kegg element: gene;26;hsa:3456 |
IFNA1 | GeneProduct | ncbigene:298210 | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA2 | GeneProduct | ncbigene:298213 | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA4 | GeneProduct | ncbigene:298205 | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA5 | GeneProduct | ncbigene:690894 | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA13 | GeneProduct | ncbigene:298207 | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
Cd86 | GeneProduct | ncbigene:56822 | Original kegg element: gene;28;hsa:942 |
Cd40 | GeneProduct | ncbigene:171369 | Original kegg element: gene;29;hsa:958 |
Fos | GeneProduct | ncbigene:314322 | Original kegg element: gene;35;hsa:2353 hsa:3725 |
Jun | GeneProduct | ncbigene:24516 | Original kegg element: gene;35;hsa:2353 hsa:3725 |
Ikbkb | GeneProduct | ncbigene:84351 | Original kegg element: gene;36;hsa:3551 |
Map3k7 | GeneProduct | ncbigene:313121 | Original kegg element: gene;37;hsa:6885 |
Ccl4 | GeneProduct | ncbigene:116637 | Original kegg element: gene;38;hsa:6351 |
Tlr7 | GeneProduct | ncbigene:317468 | Original kegg element: gene;39;hsa:51284 hsa:51311 |
TLR8 | GeneProduct | ncbigene:684440 | Original kegg element: gene;39;hsa:51284 hsa:51311 |
Mapk14 | GeneProduct | ncbigene:81649 | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
Mapk11 | GeneProduct | ncbigene:689314 | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
Mapk13 | GeneProduct | ncbigene:29513 | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
Mapk12 | GeneProduct | ncbigene:60352 | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
Irak1 | GeneProduct | ncbigene:363520 | Original kegg element: gene;41;hsa:3654 |
Chuk | GeneProduct | ncbigene:309361 | Original kegg element: gene;42;hsa:1147 |
CCL3 | GeneProduct | ncbigene:25542 | Original kegg element: gene;44;hsa:6348 |
Il12a | GeneProduct | ncbigene:84405 | Original kegg element: gene;45;hsa:3592 hsa:3593 |
Il12b | GeneProduct | ncbigene:64546 | Original kegg element: gene;45;hsa:3592 hsa:3593 |
Tirap | GeneProduct | ncbigene:680127 | Original kegg element: gene;46;hsa:114609 |
Myd88 | GeneProduct | ncbigene:301059 | Original kegg element: gene;47;hsa:4615 |
Rac1 | GeneProduct | ncbigene:363875 | Original kegg element: gene;48;hsa:5879 |
Ifnar1 | GeneProduct | ncbigene:288264 | Original kegg element: gene;49;hsa:3454 hsa:3455 |
Mapk8 | GeneProduct | ncbigene:116554 | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
Mapk9 | GeneProduct | ncbigene:50658 | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
Mapk10 | GeneProduct | ncbigene:25272 | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
Il1b | GeneProduct | ncbigene:24494 | Original kegg element: gene;51;hsa:3553 |
Tbk1 | GeneProduct | ncbigene:299827 | Original kegg element: gene;52;hsa:29110 |
Traf6 | GeneProduct | ncbigene:311245 | Original kegg element: gene;53;hsa:7189 |
Ikbke | GeneProduct | ncbigene:363984 | Original kegg element: gene;54;hsa:9641 |
Pik3r5 | GeneProduct | ncbigene:497931 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3CA | GeneProduct | ncbigene:170911 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
Pik3cb | GeneProduct | ncbigene:85243 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
Pik3cd | GeneProduct | ncbigene:366508 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
Pik3cg | GeneProduct | ncbigene:298947 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
Pik3r1 | GeneProduct | ncbigene:25513 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
Pik3r2 | GeneProduct | ncbigene:29741 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
Pik3r3 | GeneProduct | ncbigene:60664 | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
Fadd | GeneProduct | ncbigene:266610 | Original kegg element: gene;56;hsa:8772 |
Il6 | GeneProduct | ncbigene:24498 | Original kegg element: gene;57;hsa:3569 |
Ccl5 | GeneProduct | ncbigene:81780 | Original kegg element: gene;58;hsa:6352 |
MAP3K7IP1 | GeneProduct | ncbigene:315139 | Original kegg element: gene;59;hsa:10454 |
Akt3 | GeneProduct | ncbigene:29414 | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
Akt1 | GeneProduct | ncbigene:24185 | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
Akt2 | GeneProduct | ncbigene:25233 | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
Map3k7ip2 | GeneProduct | ncbigene:308267 | Original kegg element: gene;61;hsa:23118 |
Stat1 | GeneProduct | ncbigene:25124 | Original kegg element: gene;62;hsa:6772 |
Map2k7 | GeneProduct | ncbigene:363855 | Original kegg element: gene;63;hsa:5609 hsa:6416 |
Map2k4 | GeneProduct | ncbigene:287398 | Original kegg element: gene;63;hsa:5609 hsa:6416 |
Nfkbia | GeneProduct | ncbigene:25493 | Original kegg element: gene;64;hsa:4792 |
Map2k3 | GeneProduct | ncbigene:303200 | Original kegg element: gene;65;hsa:5606 hsa:5608 |
Map2k6 | GeneProduct | ncbigene:114495 | Original kegg element: gene;65;hsa:5606 hsa:5608 |
Tnf | GeneProduct | ncbigene:24835 | Original kegg element: gene;66;hsa:7124 |
Irf3 | GeneProduct | ncbigene:292892 | Original kegg element: gene;67;hsa:3661 |
Cd80 | GeneProduct | ncbigene:25408 | Original kegg element: gene;69;hsa:941 |
Tlr2 | GeneProduct | ncbigene:310553 | Original kegg element: gene;70;hsa:7097 |
LY96 | GeneProduct | ncbigene:448830 | Original kegg element: gene;71;hsa:23643 |
Tlr5 | GeneProduct | ncbigene:289337 | Original kegg element: gene;72;hsa:7100 |
Tlr3 | GeneProduct | ncbigene:364594 | Original kegg element: gene;73;hsa:7098 |
Tlr2 | GeneProduct | ncbigene:310553 | Original kegg element: gene;74;hsa:7097 |
TLR1 | GeneProduct | ncbigene:305354 | Original kegg element: gene;75;hsa:7096 |
Tlr6 | GeneProduct | ncbigene:305353 | Original kegg element: gene;76;hsa:10333 |
Lbp | GeneProduct | ncbigene:29469 | Original kegg element: gene;77;hsa:3929 |
TLR9 | GeneProduct | ncbigene:338457 | Original kegg element: gene;78;hsa:54106 |
Tlr4 | GeneProduct | ncbigene:29260 | Original kegg element: gene;79;hsa:7099 |
Ticam2 | GeneProduct | ncbigene:364867 | Original kegg element: gene;80;hsa:353376 |
Tollip | GeneProduct | ncbigene:361677 | Original kegg element: gene;81;hsa:54472 |
Tirap | GeneProduct | ncbigene:680127 | Original kegg element: gene;83;hsa:114609 |
Cd14 | GeneProduct | ncbigene:60350 | Original kegg element: gene;84;hsa:929 |
Ikbkg | GeneProduct | ncbigene:309295 | Original kegg element: gene;85;hsa:8517 |
Irak4 | GeneProduct | ncbigene:300177 | Original kegg element: gene;86;hsa:51135 |
Casp8 | GeneProduct | ncbigene:64044 | Original kegg element: gene;87;hsa:841 |