Pilocytic astrocytoma (WP2253)

Homo sapiens

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This pathway shows the relationship between BRAF signalling and the development and behavior of pilocytic astrocytoma (PA), normally induced by MAPK pathway activation. BRAF is related in two alternative mechanisms in MAPK activation; first oncogenic fusion between SRGAP3 and RAF1 (highlighted in yellow); second a 3 basepair insertion in BRAF (KIAA1549, again in yellow). This pathway is based on Figure 3" An overview of MAPK pathway alterations in PAs" from [https://doi.org/10.1038/onc.2009.73 Jones et al].

Authors

Devi , Daniela Digles , Kristina Hanspers , Denise Slenter , Friederike Ehrhart , Lauren J. Dupuis , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Diseases

Annotations

Disease Ontology

pilocytic astrocytoma malignant astrocytoma cancer

Pathway Ontology

glioma pathway mitogen activated protein kinase signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
GDP Metabolite hmdb:HMDB0000960
ERK GeneProduct interpro:IPR008350
SOS1 GeneProduct ensembl:ENSG00000115904
GRB2 GeneProduct ensembl:ENSG00000177885
RAF1 GeneProduct ensembl:ENSG00000132155
MEK GeneProduct eccode:2.7.12.2
PTPN11 GeneProduct ensembl:ENSG00000179295
NF1 GeneProduct ensembl:ENSG00000196712
RTK GeneProduct wikipathways:WP5471 RTKs have to be activated first
BRAF GeneProduct ensembl:ENSG00000157764
RAS:GTP Protein interpro:IPR020849
RAS Protein pfam:PF00071

References

  1. Integrating signals from RTKs to ERK/MAPK. McKay MM, Morrison DK. Oncogene. 2007 May 14;26(22):3113–21. PubMed Europe PMC Scholia
  2. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Jones DTW, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP. Oncogene. 2009 May 21;28(20):2119–23. PubMed Europe PMC Scholia