Acetate mediated promotion of metabolic syndrome (WP3650)

Rattus norvegicus

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Acetates produced by gut microbes stimulates the parasympathetic nervous system which causes in an increase in the release of the gastrin hormone which triggers insulin release from beta-cells. Prolonged exposure to high acetate levels promote a state of metabolic syndrome.

Authors

Egon Willighagen , Kristina Hanspers , Anders Riutta , and Denise Slenter

Activity

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Cell Type Ontology

B cell parasympathetic neuron

Disease Ontology

acquired metabolic disease

Pathway Ontology

disease pathway

Participants

Label Type Compact URI Comment
fatty acid Metabolite chebi:35366
acetate Metabolite chebi:30089
glucose Metabolite chebi:17634
fatty acid Metabolite chebi:35366
acetate Metabolite chebi:30089
gastrin Protein uniprot:P04563
insulin Protein uniprot:P01323

References

  1. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, et al. Nature. 2016 Jun 9;534(7606):213–7. PubMed Europe PMC Scholia