Oxidation by cytochrome P450 (WP1077)
Bos taurus
Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
Authors
Alex Pico , Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , Eric Weitz , and Lars WillighagenActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
xenobiotics biodegradation pathway phase I biotransformation pathway via cytochrome P450Cell Type Ontology
hepatocyte| Label | Type | Compact URI | Comment |
|---|---|---|---|
| NADPH | Metabolite | chebi:16474 | |
| O2 | Metabolite | hmdb:HMDB0001377 | |
| O2 | Metabolite | hmdb:HMDB0001377 | |
| Fe3+ | Metabolite | chebi:29034 | |
| H2O | Metabolite | hmdb:HMDB0002111 | |
| Substrate | Metabolite | wikidata:Q12119506 | |
| Substrate-OH | Metabolite | wikidata:Q542929 | |
| NADP+ | Metabolite | chebi:18009 | |
| Fe3+ | Metabolite | chebi:29034 | |
| Fe3+ | Metabolite | chebi:29034 | |
| Fe2+ | Metabolite | chebi:29033 | |
| Fe2+ | Metabolite | chebi:29033 | |
| Substrate | Metabolite | wikidata:Q12119506 | |
| Substrate | Metabolite | wikidata:Q12119506 | |
| Fe2+ | Metabolite | chebi:29033 | |
| Substrate | Metabolite | wikidata:Q12119506 | |
| Fe3+ | Metabolite | chebi:29034 | |
| Substrate | Metabolite | wikidata:Q12119506 | |
| Fe2+ | Metabolite | chebi:29033 | |
| NADH | Metabolite | chebi:16908 | |
| NAD+ | Metabolite | chebi:15846 | |
| CYP26A1 | GeneProduct | ensembl:ENSBTAG00000021118 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095596 |
| CYP4F11 | GeneProduct | ensembl:ENSBTAG00000038549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171903 |
| CYB5B | GeneProduct | ensembl:ENSBTAG00000002412 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103018 |
| CYP | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1559 |
| CYP2C8 | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138115 |
| CYP2B6 | GeneProduct | ensembl:ENSBTAG00000003871 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197408 |
| CYB5R1 | GeneProduct | ensembl:ENSBTAG00000019927 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159348 |
| CYP4F22 | GeneProduct | ensembl:ENSBTAG00000047933 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171954 |
| CYB5A | GeneProduct | ensembl:ENSBTAG00000012012 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166347 |
| CYP | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1559 |
| CYP | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1559 |
| CYP4F3 | GeneProduct | ensembl:ENSBTAG00000048257 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186526 |
| CYP1B1 | GeneProduct | ensembl:ENSBTAG00000010531 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061 |
| CYP2C18 | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108242 |
| CYB5R4 | GeneProduct | ensembl:ENSBTAG00000013591 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065615 |
| CYP4A22 | GeneProduct | ensembl:ENSBTAG00000000229 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162365 |
| CYB5B | GeneProduct | ensembl:ENSBTAG00000002412 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103018 |
| CYB5R2 | GeneProduct | ensembl:ENSBTAG00000016142 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166394 |
| CYP11B1 | GeneProduct | ensembl:ENSBTAG00000004596 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160882 |
| CYP27B1 | GeneProduct | ensembl:ENSBTAG00000016906 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111012 |
| CYP2A6 | GeneProduct | ensembl:ENSBTAG00000047815 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974 |
| CYP4F3 | GeneProduct | ensembl:ENSBTAG00000038549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186529 |
| CYP26C1 | GeneProduct | ensembl:ENSBTAG00000039973 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187553 |
| CYP | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1559 |
| CYP51A1 | GeneProduct | ensembl:ENSBTAG00000001992 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630 |
| CYP4A11 | GeneProduct | ensembl:ENSBTAG00000000229 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187048 |
| CYP2A7 | GeneProduct | ensembl:ENSBTAG00000047815 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198077 |
| CYB5B | GeneProduct | ensembl:ENSBTAG00000002412 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103018 |
| CYP7B1 | GeneProduct | ensembl:ENSBTAG00000001299 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172817 |
| CYP | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1559 |
| CYP19A1 | GeneProduct | ensembl:ENSBTAG00000014890 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137869 |
| CYP3A43 | GeneProduct | ensembl:ENSBTAG00000047379 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000021461 |
| CYP26B1 | GeneProduct | ensembl:ENSBTAG00000012212 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000003137 |
| CYP7A1 | GeneProduct | ensembl:ENSBTAG00000005287 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167910 |
| CYP3A4 | GeneProduct | ensembl:ENSBTAG00000047379 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868 |
| CYP2W1 | GeneProduct | ensembl:ENSBTAG00000017701 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073067 |
| CYP8B1 | GeneProduct | ensembl:ENSBTAG00000034106 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000180432 |
| CYP2S1 | GeneProduct | ensembl:ENSBTAG00000018240 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167600 |
| CYP39A1 | GeneProduct | ensembl:ENSBTAG00000003632 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146233 |
| CYP2R1 | GeneProduct | ensembl:ENSBTAG00000010419 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186104 |
| CYP46A1 | GeneProduct | ensembl:ENSBTAG00000035544 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000036530 |
| CYP4B1 | GeneProduct | ensembl:ENSBTAG00000011976 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142973 |
| CYP1A2 | GeneProduct | ensembl:ENSBTAG00000000085 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505 |
| CYP4V2 | GeneProduct | ensembl:ENSBTAG00000021263 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145476 |
| CYP2U1 | GeneProduct | ensembl:ENSBTAG00000012972 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155016 |
| CYP2J2 | GeneProduct | ensembl:ENSBTAG00000013693 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134716 |
| CYP4X1 | GeneProduct | ensembl:ENSBTAG00000015647 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186377 |
| CYP51A1 | GeneProduct | ensembl:ENSBTAG00000001992 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630 |
| CYP2E1 | GeneProduct | ensembl:ENSBTAG00000018365 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649 |
| CYP11A1 | GeneProduct | ensembl:ENSBTAG00000006934 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140459 |
| CYP20A1 | GeneProduct | ensembl:ENSBTAG00000000851 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119004 |
| POR | GeneProduct | ensembl:ENSBTAG00000017082 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127948 |
| CYP17A1 | GeneProduct | ensembl:ENSBTAG00000014335 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148795 |
| CYP4F2 | GeneProduct | ensembl:ENSBTAG00000038549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186115 |
| CYP3A5 | GeneProduct | ensembl:ENSBTAG00000047379 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106258 |
| CYP27A1 | GeneProduct | ensembl:ENSBTAG00000013489 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135929 |
| CYP2A13 | GeneProduct | ensembl:ENSBTAG00000047815 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197838 |
| CYP2F1 | GeneProduct | ensembl:ENSBTAG00000046805 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197446 |
| CYP2C19 | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165841 |
| CYP27C1 | GeneProduct | ensembl:ENSBTAG00000038275 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186684 |
| CYB5R3 | GeneProduct | ensembl:ENSBTAG00000016516 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100243 |
| CYP11B2 | GeneProduct | ensembl:ENSBTAG00000004596 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179142 |
| CYP24A1 | GeneProduct | ensembl:ENSBTAG00000002765 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019186 |
| CYP2C9 | GeneProduct | ensembl:ENSBTAG00000020375 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138109 |
| CYP4F12 | GeneProduct | ensembl:ENSBTAG00000038549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186204 |
| CYP1A1 | GeneProduct | ensembl:ENSBTAG00000001021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465 |
| CYB5A | GeneProduct | ensembl:ENSBTAG00000012012 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166347 |
| CYB5A | GeneProduct | ensembl:ENSBTAG00000012012 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166347 |
| MGC127055 | GeneProduct | ensembl:ENSBTAG00000026501 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100197 |
| CYP3A7 | GeneProduct | ensembl:ENSBTAG00000047379 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160870 |
References
- Toxicology [Internet]. Niesink R, Hollinger MA, De Vries J. CRC Press; 1996. 1312 p. Available from: https://books.google.com/books/about/Toxicology.html?hl=&id=mwN9QgAACAAJ OpenLibrary Worldcat