G protein signaling pathways (WP73)
Rattus norvegicus
G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as “molecular switches”. They alternate from ‘inactive’ guanosine diphosphate (GDP) to ‘active’ guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: Wikipedia
Authors
Nathan Salomonis , Bruce Conklin , Charles Redfern , Thomas Kelder , Christine Chichester , Lauren J. Dupuis , Eric Weitz , and Kristina HanspersActivity
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Cited In
- Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air (2020).
- Microarray analyses reveal novel targets of exercise-induced stress resistance in the dorsal raphe nucleus (2013).
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
G protein mediated signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IP3 | Metabolite | hmdb:HMDB0001143 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| DAG | Metabolite | kegg.compound:C00165 | |
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| Prkar2b | GeneProduct | ncbigene:24679 |
References
- G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
- G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia