Gastric acid production (WP2596)
Homo sapiens
Gastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate ions.
Authors
Andra Waagmeester , Alex Pico , Egon Willighagen , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
epithelial cell epithelial cell of stomach peptic cell stomach enteroendocrine cell parietal cell foveolar cell of stomach type ECL enteroendocrine cell gastrin secreting cellPathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Histamine | Metabolite | chemspider:753 | |
| Bicarbonate ions | Metabolite | chemspider:749 | |
| Potassium chloride | Metabolite | chemspider:4707 | |
| Sodium chloride | Metabolite | chemspider:5044 | |
| Acetylcholine | Metabolite | chemspider:182 | |
| Hydrochloric acid | Metabolite | chemspider:307 | |
| MUC6 | GeneProduct | ncbigene:4588 | |
| Pepsin B | GeneProduct | eccode:3.4.23.2 | |
| PGA3 | GeneProduct | ncbigene:643834 | |
| Pepsinogen | GeneProduct | uniprot:O95576 | |
| Secretin | GeneProduct | ncbigene:6343 | |
| Gastrin | GeneProduct | uniprot:P01350 | |
| CCK | GeneProduct | ncbigene:885 | |
| VIP | GeneProduct | ncbigene:7432 | |
| Gastric intrinsic factor | GeneProduct | uniprot:P27352 | |
| GRP | GeneProduct | ncbigene:2922 | |
| Pepsin C | GeneProduct | eccode:3.4.23.3 | |
| PGA4 | GeneProduct | ncbigene:643847 | |
| Pepsinogen | GeneProduct | uniprot:O95576 | |
| PGA5 | GeneProduct | ncbigene:5222 | |
| PGC | GeneProduct | ncbigene:5225 | |
| Gastrin | GeneProduct | uniprot:P01350 |
References
- CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Sandvik AK, Waldum HL. Am J Physiol. 1991 Jun;260(6 Pt 1):G925-8. PubMed Europe PMC Scholia
- Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Allen A, Garner A. Gut. 1980 Mar;21(3):249–62. PubMed Europe PMC Scholia
- Demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a “mucus-bicarbonate” barrier. Williams SE, Turnberg LA. Gut. 1981 Feb;22(2):94–6. PubMed Europe PMC Scholia
- Human gastric mucin. Identification of a unique species by expression cloning. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, et al. J Biol Chem. 1993 Mar 15;268(8):5879–85. PubMed Europe PMC Scholia