Male steroid hormones in cardiomyocyte energy metabolism (WP5320)
Homo sapiens
This pathway depicts the effect of testosterone and androstanedione on energy metabolism in cardiomyocytes.
Authors
Isis Sampermans , Bhavana Kapalli , Andra Waagmeester , Egon Willighagen , Alex Pico , Javier Millán Acosta , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
cardiac muscle cellPathway Ontology
classic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| progesterone | Metabolite | chebi:17026 | |
| Epiandrosterone | Metabolite | hmdb:HMDB0000365 | |
| DHEA | Metabolite | chebi:28689 | |
| Testosterone glucuronide | Metabolite | chebi:28835 | |
| Epietiocholanolone | Metabolite | hmdb:HMDB0000546 | |
| testosterone | Metabolite | chebi:17347 | |
| androsterone | Metabolite | wikidata:Q422469 | |
| Etiocholanolone | Metabolite | hmdb:HMDB0000490 | |
| 3α-Androstane-diol | Metabolite | pubchem.compound:5879 | |
| Androstanedione | Metabolite | hmdb:HMDB0000053 | |
| 3β-Androstane-diol | Metabolite | pubchem.compound:441302 | |
| 5β-Dihydro-testosterone | Metabolite | pubchem.compound:11302 | |
| oestradiol | Metabolite | chebi:23965 | |
| Testosterone-sulfate | Metabolite | pubchem.compound:119207 | |
| 3β-Eticholane-diol | Metabolite | pubchem.compound:247732 | |
| androstenediol | Metabolite | wikidata:Q2817108 | |
| cholesterol | Metabolite | chebi:16113 | |
| Androgen Receptor (AR) | Metabolite | hmdb:HMDB0001624 | |
| 3α-Etiocholane-diol | Metabolite | pubchem.compound:5880 | |
| pregnenolone | Metabolite | chebi:16581 | |
| 17a Hydroxypregnenolone | Metabolite | hmdb:HMDB0000363 | |
| Androstenedione | Metabolite | hmdb:HMDB0000053 | |
| estrone | Metabolite | chebi:17263 | |
| 5α-Dihydro-testosterone | Metabolite | pubchem.compound:10635 | |
| HSD17B3 | GeneProduct | uniprot:P37058 | |
| HSD17B2 | GeneProduct | uniprot:P37059 | |
| SRD5A1/5α-reductase | GeneProduct | uniprot:P18405 | |
| AKR1C3 | GeneProduct | uniprot:A0A0A0MSS8 | |
| 3β-HSD2 | GeneProduct | uniprot:P26439 | |
| HSD3B1 | GeneProduct | uniprot:P14060 | |
| HSD3B2 | GeneProduct | uniprot:P26439 | |
| HSD3B2 | GeneProduct | ensembl:ENSG00000203859.10 | |
| HSD3B1 | GeneProduct | ensembl:ENSG00000203857.10 | |
| SRD5A2/5β-reductase | GeneProduct | uniprot:P31213 | |
| SRD5A1 | GeneProduct | ensembl:ENSG00000145545.12 | |
| SRD5A2 | GeneProduct | ensembl:ENSG00000277893.2 | |
| 17β-HSD | Protein | uniprot:Q9BPX1 | |
| Aromatase | Protein | uniprot:P11511 | |
| HSD17B3 | Protein | uniprot:P37058 | |
| 3α-HSD | Protein | uniprot:P80701 | |
| AKR1C3 | Protein | uniprot:A0A0A0MSS8 | |
| CYP17A1(17α-hydroxylase) | Protein | uniprot:P05093 | |
| 17β-HSD | Protein | ena.embl:CHEMBL4234 | |
| Sulfotransferase | Protein | uniprot:P50225 | |
| HSD17B2 | Protein | uniprot:P37059 | |
| 3β-HSD | Protein | uniprot:Q9N119 | |
| CYP17A1(C17,20-lyase) | Protein | uniprot:P05093 | |
| CYP11A1 | Protein | uniprot:P05108 | |
| Glucuronosyl-transferase | Protein | uniprot:P22309 |
References
- Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer. Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, et al. Sci Rep. 2013;3:1528. PubMed Europe PMC Scholia
- Androgen Physiology: Receptor and Metabolic Disorders. McEwan IJ, Brinkmann AO. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, et al., editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2021. PubMed Europe PMC Scholia
- Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Davey RA, Grossmann M. Clin Biochem Rev. 2016 Feb;37(1):3–15. PubMed Europe PMC Scholia
- Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes. Carbajal-García A, Reyes-García J, Montaño LM. Int J Endocrinol. 2020 Nov 12;2020:8849641. PubMed Europe PMC Scholia