ATR signaling (WP3875)

Homo sapiens

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This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3875 CPTAC Assay Portal]

Authors

AAR&Co , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

DNA replication pathway DNA damage response pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ATRIP GeneProduct ensembl:ENSG00000164053
RAD9B GeneProduct ensembl:ENSG00000151164
RAD1 GeneProduct ensembl:ENSG00000113456
CHEK1 GeneProduct ensembl:ENSG00000149554
RAD9A GeneProduct ensembl:ENSG00000172613
HUS1 GeneProduct ensembl:ENSG00000136273
ATR GeneProduct ensembl:ENSG00000175054
RPA2 GeneProduct hgnc.symbol:RPA2
RPA3 GeneProduct hgnc.symbol:RPA3
RPA1 GeneProduct hgnc.symbol:RPA1
TOPBP1 GeneProduct ensembl:ENSG00000163781

References

  1. ATR signalling: more than meeting at the fork. Nam EA, Cortez D. Biochem J. 2011 Jun 15;436(3):527–36. PubMed Europe PMC Scholia