Welcome to the Serious Request 2024 - MetaKids page.
The Serious Request 2024 action is to raise funding for MetaKids, a Dutch foundation that aims for a world in which metabolic diseases can be treated or prevented and where no kid has to suffers from these diseases.
This WikiPathways actions aims to raise funding for the Serious Request 2024 action and in return we will work in December on improving the digitalized versions of the latest literature about the biological process that are behind or could perhaps explain these metabolic diseases.
This page lists the pathways we worked on during the action or are otherwise relevant to the work by the MetaKids foundation. We further have this project board to monitor the specific tasks, in an open notebook science sense. Also, a dedicated curation website is maintained.
See also the "WikiPathways in actie voor MetaKids" page where you can donate money for MetaKids. It has been reported that people outside The Netherlands can use PayPal to make donations.
Work done
- On Friday curation continued on the new pathways but also other focus pathways, decreasing the number of points brought up on this curation page.
- Thursday resulted in (major) improvements to WP5504 and WP5505, and two new pathways from two new contributors (Daan and Marek): WP5506 and WP5507.
- On Wednesday we used the full list of 1384 genes to add about 30 additional pathways to our curation focus list.
- On Tuesday a new pathway was started from the list of 347 genes: WP5505.
- On Monday we compared 1384 genes with WikiPathways and Reactome: 347 and and 129 were not in the database respectively.
- On Sunday a new metabolite ID mapping database was created, and a first new pathway was drawn: WP5504.
Pathways planned to work on
- Pathways directly linked to diseases currently mentioned in research articles by United for Metabolic Diseases, e.g. WP4156
- Pathways describing mitochondrial processes
- Pathways not digitized in the book behind the IMD portal, see this table
Contact
Denise Slenter , Egon Willighagen , and Martina Summer-Kutmon .
Community Pathways
Table FiltersThis community helps to curate 36 pathways:
- Amino acid metabolism - WP3925 (Homo sapiens)
- Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine - WP4156 (Homo sapiens)
- Cholesterol metabolism with Bloch and Kandutsch-Russell pathways - WP4718 (Homo sapiens)
- Clear cell renal cell carcinoma pathways - WP4018 (Homo sapiens)
- Cytoplasmic ribosomal proteins - WP477 (Homo sapiens)
- Disorders of Mitochondrial Homeostatis, Dynamics, Protein Import, and Quality Control - WP5504 (Homo sapiens)
- Disorders of NAD metabolism - WP5506 (Homo sapiens)
- Disorders of bile acid synthesis and biliary transport - WP5176 (Homo sapiens)
- Disorders of fructose metabolism - WP5178 (Homo sapiens)
- Disorders of galactose metabolism - WP5173 (Homo sapiens)
- Electron transport chain: OXPHOS system in mitochondria - WP111 (Homo sapiens)
- Familial hyperlipidemia type 5 - WP5112 (Homo sapiens)
- Fatty acid beta-oxidation - WP143 (Homo sapiens)
- Folate metabolism - WP176 (Homo sapiens)
- Glycolysis and gluconeogenesis - WP534 (Homo sapiens)
- Glycosaminoglycan degradation - WP4815 (Homo sapiens)
- Glycosylphosphatidyl inositol anchor pathway - WP5505 (Homo sapiens)
- Heme biosynthesis - WP561 (Homo sapiens)
- Metabolic reprogramming in colon cancer - WP4290 (Homo sapiens)
- Metapathway biotransformation Phase I and II - WP702 (Homo sapiens)
- Mitochondrial carrier deficiency associated with shuttle disturbances - WP5507 (Homo sapiens)
- Mitochondrial complex I assembly model OXPHOS system - WP4324 (Homo sapiens)
- Mitochondrial complex II assembly - WP4920 (Homo sapiens)
- Mitochondrial complex IV assembly - WP4922 (Homo sapiens)
- NRF2 pathway - WP2884 (Homo sapiens)
- Neuroinflammation and glutamatergic signaling - WP5083 (Homo sapiens)
- Non-genomic actions of 1,25-dihydroxyvitamin D3 - WP4341 (Homo sapiens)
- Nonalcoholic fatty liver disease - WP4396 (Homo sapiens)
- Oxidative phosphorylation - WP623 (Homo sapiens)
- PPAR signaling - WP3942 (Homo sapiens)
- Pathways of nucleic acid metabolism and innate immune sensing - WP4705 (Homo sapiens)
- Proteoglycan biosynthesis - WP4784 (Homo sapiens)
- Proximal tubule transport - WP4917 (Homo sapiens)
- Pyrimidine metabolism - WP4022 (Homo sapiens)
- Statin inhibition of cholesterol production - WP430 (Homo sapiens)
- Sterol regulatory element-binding proteins (SREBP) signaling - WP1982 (Homo sapiens)
Community Members
Daanvanbeek , Denise Slenter , Egon Willighagen , Laura Steinbusch , Mareknoga , and Martina Summer-Kutmon .
Authors of Community Pathways
Daanvanbeek , Denise Slenter , Egon Willighagen , Laura Steinbusch , Mareknoga , Martina Summer-Kutmon , Kristina Hanspers , Eric Weitz , Irene Hemel , Daniela Digles , Josien Landman , Friederike Ehrhart , Finterly Hu , Alex Pico , Kdahlquist , Martijn Van Iersel , Christine Chichester , Maria van de Meent , Enzo Chiaradia , Sam Drabbe , Lars Willighagen , Alexandra Bosch , Ferry Jagers , Aishwarya Iyer , Ulas Babayigit , Michiel Adriaens , Chris Evelo , Susan Coort , Patrick Ahles , Adrien Defay , Priyanka K , Licong , Egoyenechea , Thomas Kelder , Jill Dunham , Damariz Rivero , Jildau Bouwman , Andra Waagmeester , Youssef Walid , Marvin Martens , Nick Fidelman , The Herald , Mirk Baranzini , Mark A. Hershberger , Ambar21 , Ritchie Lee , Caroline Miller , Pieter Giesbertz , Anna Baya Meuleman , Rianne Fijten , Bart Smeets , Zahra Roudbari , Elisa Cirillo , Lauren J. Dupuis , Lisa Koole , Allan Kuchinsky , Laurent Winckers , Andreas Zankl , Anna Hoekstra , Nathan Salomonis , Bruce Conklin , Samuel Sklar , Anwesha Bohler , Sabine Daemen , Dan Bolser , and Marianthi Kalafati .