Retinoblastoma gene in cancer (WP3206)
Bos taurus
Describes the role of retinoblastoma (RB) gene in cancer.
Authors
Martina Summer-Kutmon , Linda Rieswijk , Alex Pico , Friederike Ehrhart , Egon Willighagen , and Eric WeitzActivity
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Cited In
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
disease pathway cancer pathwayDisease Ontology
cancerLabel | Type | Compact URI | Comment |
---|---|---|---|
RB1 | GeneProduct | ensembl:ENSBTAG00000006640 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925 |
E2F1 | GeneProduct | ensembl:ENSBTAG00000003971 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869 |
TFDP1 | GeneProduct | ensembl:ENSBTAG00000019645 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027 |
ABL1 | GeneProduct | ensembl:ENSBTAG00000017976 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25 |
RBP1 | GeneProduct | ensembl:ENSBTAG00000020028 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5947 |
HDAC1 | GeneProduct | ensembl:ENSBTAG00000012698 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065 |
SKP2 | GeneProduct | ensembl:ENSBTAG00000013562 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502 |
CDKN1B | GeneProduct | ensembl:ENSBTAG00000018254 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027 |
CDK2 | GeneProduct | ensembl:ENSBTAG00000004021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017 |
CCNE1 | GeneProduct | ensembl:ENSBTAG00000004735 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898 |
MYC | GeneProduct | ensembl:ENSBTAG00000008409 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609 |
CCNA2 | GeneProduct | ensembl:ENSBTAG00000004943 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890 |
MDM2 | GeneProduct | ensembl:ENSBTAG00000010422 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193 |
TP53 | GeneProduct | ensembl:ENSBTAG00000001069 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157 |
DNMT1 | GeneProduct | ensembl:ENSBTAG00000002736 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1786 |
HRMT1L1 | GeneProduct | ensembl:ENSBTAG00000005503 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3275 |
MCM7 | GeneProduct | ensembl:ENSBTAG00000030965 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176 |
SUV39H1 | GeneProduct | ensembl:ENSBTAG00000004706 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6839 |
RAF1 | GeneProduct | ensembl:ENSBTAG00000045748 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894 |
MAPK13 | GeneProduct | ensembl:ENSBTAG00000010007 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5603 |
CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026 |
CCNE2 | GeneProduct | ensembl:ENSBTAG00000004906 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9134 |
CDC25A | GeneProduct | ensembl:ENSBTAG00000009586 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993 |
CCND3 | GeneProduct | ensembl:ENSBTAG00000010106 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896 |
CDK1 | GeneProduct | ensembl:ENSBTAG00000010109 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983 |
PLK4 | GeneProduct | ensembl:ENSBTAG00000039552 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10733 |
NPAT | GeneProduct | ensembl:ENSBTAG00000010286 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4863 |
CCDC6 | GeneProduct | ensembl:ENSBTAG00000003189 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8030 |
CCNB1 | GeneProduct | ensembl:ENSBTAG00000014239 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:891 |
CCNB2 | GeneProduct | ensembl:ENSBTAG00000005269 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133 |
MCM6 | GeneProduct | ensembl:ENSBTAG00000015172 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175 |
RFC4 | GeneProduct | ensembl:ENSBTAG00000014727 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5984 |
TOP2A | GeneProduct | ensembl:ENSBTAG00000019262 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7153 |
CDC45L | GeneProduct | ensembl:ENSBTAG00000004286 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318 |
MCM3 | GeneProduct | ensembl:ENSBTAG00000010721 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172 |
RFC5 | GeneProduct | ensembl:ENSBTAG00000007137 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5985 |
RFC3 | GeneProduct | ensembl:ENSBTAG00000010787 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5983 |
MCM4 | GeneProduct | ensembl:ENSBTAG00000017021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173 |
POLE | GeneProduct | ensembl:ENSBTAG00000000590 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5426 |
POLA1 | GeneProduct | ensembl:ENSBTAG00000008170 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5422 |
PRIM1 | GeneProduct | ensembl:ENSBTAG00000044000 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5557 |
ORC1 | GeneProduct | ensembl:ENSBTAG00000002719 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998 |
CDT1 | GeneProduct | ensembl:ENSBTAG00000000638 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81620 |
SMARCA2 | GeneProduct | ensembl:ENSBTAG00000007494 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6595 |
CHEK1 | GeneProduct | ensembl:ENSBTAG00000017582 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1111 |
PCNA | GeneProduct | ensembl:ENSBTAG00000006065 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111 |
RPA1 | GeneProduct | ensembl:ENSBTAG00000009711 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6117 |
MSH6 | GeneProduct | ensembl:ENSBTAG00000001424 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2956 |
PRKDC | GeneProduct | ensembl:ENSBTAG00000017019 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591 |
BARD1 | GeneProduct | ensembl:ENSBTAG00000033690 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:580 |
TTK | GeneProduct | ensembl:ENSBTAG00000005456 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7272 |
SMC2 | GeneProduct | ensembl:ENSBTAG00000008772 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10592 |
KIF4A | GeneProduct | ensembl:ENSBTAG00000012861 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:24137 |
RRM1 | GeneProduct | ensembl:ENSBTAG00000013111 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6240 |
RRM2 | GeneProduct | ensembl:ENSBTAG00000008216 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6241 |
DHFR | GeneProduct | ensembl:ENSBTAG00000007681 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1719 |
DCK | GeneProduct | ensembl:ENSBTAG00000012397 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1633 |
HMGB2 | GeneProduct | ensembl:ENSBTAG00000015101 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3148 |
TYMS | GeneProduct | ensembl:ENSBTAG00000007003 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7298 |
STMN1 | GeneProduct | ensembl:ENSBTAG00000026505 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3925 |
RABIF | GeneProduct | ensembl:ENSBTAG00000013560 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5877 |
HLTF | GeneProduct | ensembl:ENSBTAG00000019704 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6596 |
ANLN | GeneProduct | ensembl:ENSBTAG00000009218 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54443 |
HMGB1 | GeneProduct | ensembl:ENSBTAG00000014862 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3146 |
CDC7L1 | GeneProduct | ensembl:ENSBTAG00000016307 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317 |
WEE1 | GeneProduct | ensembl:ENSBTAG00000005278 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7465 |
POLE2 | GeneProduct | ensembl:ENSBTAG00000004931 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5427 |
CDC25B | GeneProduct | ensembl:ENSBTAG00000008436 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994 |
SMC3 | GeneProduct | ensembl:ENSBTAG00000013905 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9126 |
SMC1A | GeneProduct | ensembl:ENSBTAG00000017761 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243 |
MGC159566 | GeneProduct | ensembl:ENSBTAG00000015005 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2189 |
FAF1 | GeneProduct | ensembl:ENSBTAG00000014482 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11124 |
POLD3 | GeneProduct | ensembl:ENSBTAG00000016869 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10714 |
H2AFZ | GeneProduct | ensembl:ENSBTAG00000004428 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3015 |
SAP30 | GeneProduct | ensembl:ENSBTAG00000015578 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8819 |
SIN3A | GeneProduct | ensembl:ENSBTAG00000009985 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25942 |
RBBP7 | GeneProduct | ensembl:ENSBTAG00000002820 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5931 |
RBBP4 | GeneProduct | ensembl:ENSBTAG00000005904 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5928 |
CDK4 | GeneProduct | ensembl:ENSBTAG00000046091 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019 |
CCND1 | GeneProduct | ensembl:ENSBTAG00000017514 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595 |
E2F2 | GeneProduct | ensembl:ENSBTAG00000014400 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1870 |
E2F3 | GeneProduct | ensembl:ENSBTAG00000021045 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1871 |
TFDP2 | GeneProduct | ensembl:ENSBTAG00000006222 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7029 |
CDK6 | GeneProduct | ensembl:ENSBTAG00000044023 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021 |
RPA1 | Protein | ensembl:ENSBTAG00000009711 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6117 |
RPA2 | Protein | ensembl:ENSBTAG00000006225 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6118 |
RPA3 | Protein | ensembl:ENSBTAG00000013168 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6119 |
References
- Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms. Welch PJ, Wang JY. Mol Cell Biol. 1995 Oct;15(10):5542–51. PubMed Europe PMC Scholia
- A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Welch PJ, Wang JY. Cell. 1993 Nov 19;75(4):779–90. PubMed Europe PMC Scholia
- Leukoencephalopathy: the frontier between what is reversible and what is persistent. Domínguez R, Famulari A, Vila J. Rev Neurol. 1997 Dec;25(148):2074. PubMed Europe PMC Scholia
- An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, et al. Mol Cell. 2004 Oct 8;16(1):47–58. PubMed Europe PMC Scholia
- MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, et al. Mol Cell Biol. 2008 Sep;28(17):5369–80. PubMed Europe PMC Scholia
- MicroRNA 29b functions in acute myeloid leukemia. Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, et al. Blood. 2009 Dec 17;114(26):5331–41. PubMed Europe PMC Scholia
- MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, et al. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098–103. PubMed Europe PMC Scholia