Bone morphogenic protein signaling and regulation (WP1425)

Homo sapiens

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"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." [http://www.ncbi.nlm.nih.gov/pubmed/15621726 (Chen 2004)]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1425 CPTAC Assay Portal]

Authors

Andra Waagmeester , Kristina Hanspers , Alex Pico , Vfunari , Babiker Malik Osman , Martijn Van Iersel , Marianthi Kalafati , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Bone morphogenetic proteins signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
RUNX2 GeneProduct ensembl:ENSG00000124813
SMAD6 GeneProduct ensembl:ENSG00000137834
SMURF1 GeneProduct ensembl:ENSG00000198742
TOB1 GeneProduct ensembl:ENSG00000141232
SMAD1 GeneProduct ensembl:ENSG00000170365
BMPR1A GeneProduct ensembl:ENSG00000107779
NOG GeneProduct ensembl:ENSG00000183691
BMPR2 GeneProduct ncbigene:659
SMAD4 GeneProduct ensembl:ENSG00000141646
BMP2 GeneProduct ensembl:ENSG00000125845
TOB2 GeneProduct ensembl:ENSG00000183864
BMPR1B GeneProduct ensembl:ENSG00000138696

References

  1. Bone morphogenetic proteins. Chen D, Zhao M, Mundy GR. Growth Factors. 2004 Dec;22(4):233–41. PubMed Europe PMC Scholia