TP53 network (WP1742)

Homo sapiens

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P53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high level of sequence homology in its DNA binding domain. The complexity of the family has been enriched by the alternatively spliced forms of the genes. At present pathway, the alternatively spliced forms of p63 and p73 and how they interact with p53 are shown . However, little is known about the transcriptional regulation of p53 family members. Further studies will tell us whether the three genes of the family also share others regulatory activities. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1742 CPTAC Assay Portal]

Authors

Glenda Nicioli Da Silva , Alex Pico , Kristina Hanspers , Andra Waagmeester , Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

p53 signaling pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
CDKN1A GeneProduct ensembl:ENSG00000124762
BID GeneProduct ensembl:ENSG00000015475
ABL1 GeneProduct ncbigene:25
BOK GeneProduct ncbigene:666
BAX GeneProduct ncbigene:581
PMAIP1 GeneProduct ncbigene:5366
MYC GeneProduct ncbigene:4609
BCL2 GeneProduct ensembl:ENSG00000171791
TP53 GeneProduct ncbigene:7157
CDKN2A GeneProduct ncbigene:1029
BBC3 GeneProduct ncbigene:27113
TP73 GeneProduct ncbigene:7161
GADD45A GeneProduct ncbigene:1647
IGFBP-3 GeneProduct ensembl:ENSG00000235943
TP63 GeneProduct ncbigene:8626
ATM GeneProduct ensembl:ENSG00000149311
OTX2 GeneProduct ensembl:ENSG00000165588
MDM2 GeneProduct ensembl:ENSG00000135679
TNFSF10 GeneProduct ncbigene:8743
DeltaNp63gamma Protein uniprot:Q9H3D4
TAp63beta Protein uniprot:Q9H3D4
DelatNp63alpha Protein uniprot:Q9H3D4
TP73 Delta Np73 Protein uniprot:O15350
TP73zeta Protein uniprot:O15350
SUMO1 Protein ncbigene:7341
TP73delta Protein uniprot:O15350
TP73alpha Protein uniprot:O15350
TAp63gamma Protein uniprot:Q9H3D4
TP73gamma Protein uniprot:O15350
TP73beta Protein uniprot:O15350
TAp63alpha Protein uniprot:Q9H3D4
TP73epsilon Protein uniprot:O15350
DeltaNp63beta Protein uniprot:Q9H3D4

References

  1. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, et al. Mol Cell. 1998 Sep;2(3):305–16. PubMed Europe PMC Scholia
  2. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, et al. Nature. 1999 Jun 24;399(6738):814–7. PubMed Europe PMC Scholia
  3. c-Abl: activation and nuclear targets. Shaul Y. Cell Death Differ. 2000 Jan;7(1):10–6. PubMed Europe PMC Scholia
  4. p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Dohn M, Zhang S, Chen X. Oncogene. 2001 May 31;20(25):3193–205. PubMed Europe PMC Scholia
  5. Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S. Cancer Res. 2002 Feb 1;62(3):636–41. PubMed Europe PMC Scholia
  6. Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines. Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, et al. Mol Cancer Res. 2010 Oct;8(10):1344–57. PubMed Europe PMC Scholia