Male infertility (WP4673)
Homo sapiens
Pathway(s) of genes involved in male infertility. The list of genes is derived from Krausz et al.(1) and can be sorted in general (common) cell function, endocrine function and specific spermatogenic function.
Authors
Friederike Ehrhart , Egon Willighagen , and Eric WeitzActivity
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Cited In
- The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study (2022).
- Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D (2022).
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
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Organisms
Homo sapiensCommunities
Rare DiseasesAnnotations
Cell Type Ontology
spermPathway Ontology
disease pathwayDisease Ontology
male infertilityReferences
- Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization. Tekur S, Pawlak A, Guellaen G, Hecht NB. J Androl. 1999;20(1):135–44. PubMed Europe PMC Scholia
- Structure and conserved RNA binding of the PAZ domain. Yan KS, Yan S, Farooq A, Han A, Zeng L, Zhou MM. Nature. 2003 Nov 27;426(6965):468–74. PubMed Europe PMC Scholia
- Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Kalmykova AI, Klenov MS, Gvozdev VA. Nucleic Acids Res. 2005 Apr 7;33(6):2052–9. PubMed Europe PMC Scholia
- Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells. Reynolds N, Collier B, Maratou K, Bingham V, Speed RM, Taggart M, et al. Hum Mol Genet. 2005 Dec 15;14(24):3899–909. PubMed Europe PMC Scholia
- Arginine methylation regulates DNA polymerase beta. El-Andaloussi N, Valovka T, Toueille M, Steinacher R, Focke F, Gehrig P, et al. Mol Cell. 2006 Apr 7;22(1):51–62. PubMed Europe PMC Scholia
- Clarifying the mechanics of DNA strand exchange in meiotic recombination. Neale MJ, Keeney S. Nature. 2006 Jul 13;442(7099):153–8. PubMed Europe PMC Scholia
- Lysine propionylation and butyrylation are novel post-translational modifications in histones. Chen Y, Sprung R, Tang Y, Ball H, Sangras B, Kim SC, et al. Mol Cell Proteomics. 2007 May;6(5):812–9. PubMed Europe PMC Scholia
- Thrombospondin-1 is a transcriptional repression target of PRMT6. Michaud-Levesque J, Richard S. J Biol Chem. 2009 Aug 7;284(32):21338–46. PubMed Europe PMC Scholia
- Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. Wojtasz L, Daniel K, Roig I, Bolcun-Filas E, Xu H, Boonsanay V, et al. PLoS Genet. 2009 Oct;5(10):e1000702. PubMed Europe PMC Scholia
- Identification of increased amounts of eppin protein complex components in sperm cells of diabetic and obese individuals by difference gel electrophoresis. Paasch U, Heidenreich F, Pursche T, Kuhlisch E, Kettner K, Grunewald S, et al. Mol Cell Proteomics. 2011 Aug;10(8):M110.007187. PubMed Europe PMC Scholia
- NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells. Ginter-Matuszewska B, Kusz K, Spik A, Grzeszkowiak D, Rembiszewska A, Kupryjanczyk J, et al. Histochem Cell Biol. 2011 Sep;136(3):279–87. PubMed Europe PMC Scholia
- Functional studies of eppin. O’Rand MG, Widgren EE, Hamil KG, Silva EJ, Richardson RT. Biochem Soc Trans. 2011 Oct;39(5):1447–9. PubMed Europe PMC Scholia
- Bromodomain-dependent stage-specific male genome programming by Brdt. Gaucher J, Boussouar F, Montellier E, Curtet S, Buchou T, Bertrand S, et al. EMBO J. 2012 Oct 3;31(19):3809–20. PubMed Europe PMC Scholia
- PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion. Kim NH, Kim SN, Seo DW, Han JW, Kim YK. Biochem Biophys Res Commun. 2013 Mar 1;432(1):60–5. PubMed Europe PMC Scholia
- The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, et al. Genes Dev. 2015 Mar 15;29(6):617–29. PubMed Europe PMC Scholia
- Genetics of male infertility: from research to clinic. Krausz C, Escamilla AR, Chianese C. Reproduction. 2015 Nov;150(5):R159-74. PubMed Europe PMC Scholia
- Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, et al. Mol Cell. 2016 Apr 21;62(2):169–80. PubMed Europe PMC Scholia
- The PRDM9 KRAB domain is required for meiosis and involved in protein interactions. Imai Y, Baudat F, Taillepierre M, Stanzione M, Toth A, de Massy B. Chromosoma. 2017 Dec;126(6):681–95. PubMed Europe PMC Scholia
- Maternal Dead-end 1 promotes translation of nanos1 by binding the eIF3 complex. Aguero T, Jin Z, Chorghade S, Kalsotra A, King ML, Yang J. Development. 2017 Oct 15;144(20):3755–65. PubMed Europe PMC Scholia
- A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis. Altemose N, Noor N, Bitoun E, Tumian A, Imbeault M, Chapman JR, et al. Elife. 2017 Oct 26;6:e28383. PubMed Europe PMC Scholia
- Altered PIWI-LIKE 1 and PIWI-LIKE 2 mRNA expression in ejaculated spermatozoa of men with impaired sperm characteristics. Giebler M, Greither T, Müller L, Mösinger C, Behre HM. Asian J Androl. 2018;20(3):260–4. PubMed Europe PMC Scholia
- Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress. Karaman M, Budak H, Çiftci M. Arch Physiol Biochem. 2019 Dec;125(5):447–55. PubMed Europe PMC Scholia
- Among seven testis-specific molecular markers, SPEM1 appears to have a significant clinical value for prediction of sperm retrieval in azoospermic men. Hashemi MS, Mozdarani H, Ghaedi K, Nasr-Esfahani MH. Andrology. 2018 Nov;6(6):890–5. PubMed Europe PMC Scholia