daf-2 or insulin signaling pathway (WP17)

Caenorhabditis elegans

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Insulin receptor pathway in C. elegans Initial version based on review by [https://www.ncbi.nlm.nih.gov/pubmed/16441841 Gami and Wolkow] of pathways that affect ageing. The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. C. elegans with a diet of low glucose, reduced Daf-16 activity and worms lifespan was shortened compared to worms fed on media without glucose.

Authors

Martijn Van Iersel , Pieter Giesbertz , Christine Chichester , Christian Grove , Karen Yook , Asios Olia , Kristina Hanspers , and Egon Willighagen

Activity

last edited

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Organisms

Caenorhabditis elegans

Communities

WormBase

Annotations

Pathway Ontology

aging pathway insulin-like growth factor signaling pathway

Participants

Label Type Compact URI Comment
PIP Metabolite hmdb:HMDB0004249
SGK-1 GeneProduct ensembl:WBGene00004789
AKT-1 GeneProduct ensembl:WBGene00000102
PDK-1 GeneProduct ensembl:WBGene00003965
DAF-2/INSR GeneProduct ensembl:WBGene00000898
DAF-18/PTEN GeneProduct ensembl:WBGene00000913
AKT-2 GeneProduct ensembl:WBGene00000103
AGE-1/PI-3K GeneProduct ensembl:WBGene00000090
DAF-16/FOXO GeneProduct ensembl:WBGene00000912

References

  1. Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan. Gami MS, Wolkow CA. Aging Cell. 2006 Feb;5(1):31–7. PubMed Europe PMC Scholia