Fluoroacetic acid toxicity (WP4966)
Homo sapiens
Pathway on fluoroacetic acid toxicity describing how it ultimately leads to disturbance of the Krebs cycle.
Authors
Marvin Martens , Egon Willighagen , Denise Slenter , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
altered citric acid cycle pathway disease pathway altered metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Isocitric acid | Metabolite | chebi:30887 | |
| 4-Hydroxy-trans-aconitate | Metabolite | wikidata:Q76106265 | |
| Fluoroacetic acid | Metabolite | chebi:30775 | |
| Fluoroacetyl-CoA | Metabolite | pubchem.compound:49859653 | |
| Citric acid | Metabolite | chebi:30769 | |
| Acetate | Metabolite | cas:71-50-1 | |
| Fluoroacetaldehyde | Metabolite | chebi:14272 | |
| Fluorocitric acid | Metabolite | cas:357-89-1 | |
| Aconitase | GeneProduct | ensembl:ENSG00000100412 | |
| ALDH3A2 | GeneProduct | ensembl:ENSG00000072210 | |
| ALDH9A1 | GeneProduct | ensembl:ENSG00000143149 | |
| Acetyl-CoA synthetase | GeneProduct | ensembl:ENSG00000131069 | |
| ALDH2 | GeneProduct | ensembl:ENSG00000111275 | |
| Citrate synthase | GeneProduct | ncbigene:1431 |
References
- Metabolic and Pharmaceutical Aspects of Fluorinated Compounds. Johnson BM, Shu YZ, Zhuo X, Meanwell NA. J Med Chem. 2020 Jun 25;63(12):6315–86. PubMed Europe PMC Scholia