Sulfur amino acid biosynthesis

Sulfur amino acid biosynthesis (WP7)

The synthesis of methionine and cysteine (among other sulfur-containing compounds) from sulfate, ATP, NADPH, and serine.

Jessica Heckman , Kristina Hanspers , Egon Willighagen , Daniela Digles , Denise Slenter , Alex Pico , and Eric Weitz

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Saccharomyces cerevisiae

Label	Type	Compact URI	Comment
Coenzyme A	Metabolite	cas:64885-97-8
ATP	Metabolite	cas:1927-31-7
homoserine	Metabolite	cas:672-15-1
L-serine	Metabolite	cas:56-45-1
L-methionine	Metabolite	cas:63-68-3
NADPH	Metabolite	cas:53-57-6
3 NADPH	Metabolite	cas:53-57-6
acetate	Metabolite	cas:64-19-7
acetyl-CoA	Metabolite	cas:72-89-9
adenosine-3',5'-bisphosphate	Metabolite	cas:3805-37-6
phosphate	Metabolite	cas:14265-44-2
pyrophosphate	Metabolite	cas:2466-09-3
L-cysteine	Metabolite	cas:52-90-4
ADP	Metabolite	cas:58-64-0
cystathionine	Metabolite	cas:535-34-2
homocysteine	Metabolite	cas:6027-13-0
STR2	GeneProduct	sgd:S000003891
STR3	GeneProduct	sgd:S000003152
CYS4	GeneProduct	sgd:S000003387
MET16	GeneProduct	sgd:S000006371
MET10	GeneProduct	sgd:S000001926
MET6	GeneProduct	sgd:S000000893	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
ECM17	GeneProduct	sgd:S000003898
MET3	GeneProduct	sgd:S000003771
SAM1	GeneProduct	sgd:S000004170
MET14	GeneProduct	sgd:S000001484
MET17	GeneProduct	sgd:S000004294
MET2	GeneProduct	sgd:S000005221
SAM2	GeneProduct	sgd:S000002910
CYS3	GeneProduct	sgd:S000000010

Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Thomas D, Surdin-Kerjan Y. Microbiol Mol Biol Rev. 1997 Dec;61(4):503–32. PubMed Europe PMC Scholia