N-glycan biosynthesis (WP5196)
Ovis aries
N-Glycan biosynthesis - Ovis Aries (Sheep)
Authors
ChristeldeVries , Egon Willighagen , Eric Weitz , and Alex PicoActivity
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Organisms
Communities
Annotations
Pathway Ontology
glycan metabolic pathway N-linked glycan biosynthetic pathway lipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| (GlcNAc)2 (Man)2 (PP-Dol)1 | Metabolite | kegg.glycan:G00004 | Sometimes referred to as: - Alpha-D-Mannosyl-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol |
| (GlcNAc)2 (Man)7 (PP-Dol)1 | Metabolite | kegg.glycan:G10596 | |
| (GlcNAc)2 (Man)3 (PP-Dol)1 | Metabolite | kegg.glycan:G00005 | |
| Dolichyl Beta-D-Glucosyl Phosphate | Metabolite | lipidmaps:LMPR03080014 | Sometimes referred to as: - α-(3-methylbut-2-en-1-yl)-�‰-{4-[(β-D-glucopyranosyloxy)(hydroxy)phosphoryloxy]-2-methylbutyl}poly[(2E)-2-methylbut-2-ene-1,4-diyl] - Dolichyl beta-D-glucosyl phosphate |
| (Gal)2 (GlcNAc)4 (LFuc)1 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00017 | |
| (Gal)2 (GlcNAc)4 (LFuc)1 (Man)3 (Neu5Ac)2 (Asn)1 | Metabolite | kegg.glycan:G00018 | |
| Dolichyl Phosphate | Metabolite | lipidmaps:LMPR03080015 | Sometimes referred to as: - Dolichol phosphate - Dolicholmonophosphate |
| (GlcNAc)6 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00021 | |
| N,N'-Chitobiosyldiphosphodolichol | Metabolite | kegg.glycan:G00002 | |
| (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | kegg.glycan:G00011 | |
| (GlcNAc)5 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00020 | |
| (GlcNAc)2 (Man)5 (PP-Dol)1 | Metabolite | kegg.glycan:G00006 | Sometimes referred to as: - (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol |
| (GlcNAc)3 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00014 | |
| (GlcNAc)2 (Man)8 (PP-Dol)1 | Metabolite | kegg.glycan:G10597 | |
| Dolichol | Metabolite | chebi:16091 | |
| (GlcNAc)4 (LFuc)1 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00016 | |
| (Glc)1 (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | kegg.glycan:G00010 | |
| GDP-mannose | Metabolite | kegg.compound:C00096 | Sometimes referred to as: - GDP mannose - GDP-mannose - GDP-alpha-D-mannose - Guanosine diphosphate mannose - The α-anomer of GDP-D-mannose |
| (Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | kegg.glycan:G10598 | |
| Beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol | Metabolite | kegg.glycan:G00003 | |
| Ditrans,polycis-polyprenol | Metabolite | chebi:67132 | In literature also simply refered to as polyprenol. |
| (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | kegg.glycan:G00007 | |
| (Glc)3 (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | kegg.glycan:G00009 | |
| (GlcNAc)7 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00022 | |
| (GlcNAc)2 (Man)5 (Asn)1 | Metabolite | kegg.glycan:G00012 | |
| Dolichyl phosphate D-mannose | Metabolite | pubchem.substance:6598 | Sometimes referred to as: - Dolichyl phosphate D-mannose - Dolichyl D-mannosyl phosphate - Dolichyl beta-D-mannosyl phosphate |
| (GlcNAc)2 (Man)8 (Asn)1 | Metabolite | kegg.glycan:G10694 | |
| (GlcNAc)4 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00015 | |
| N-Acetyl-D-glucosaminyldiphosphodolichol | Metabolite | kegg.glycan:G00001 | |
| (GlcNAc)2 (Man)4 (PP-Dol)1 | Metabolite | kegg.glycan:G10526 | |
| Dolichyl Diphosphate | Metabolite | lipidmaps:LMPR03090023 | Sometimes referred to as: - Dolichol diphosphate |
| (Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | kegg.glycan:G10599 | |
| (Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | kegg.glycan:G00008 | |
| (GlcNAc)3 (Man)5 (Asn)1 | Metabolite | kegg.glycan:G00013 | |
| (GlcNAc)5 (Man)3 (Asn)1 | Metabolite | kegg.glycan:G00019 | |
| (GlcNAc)2 (Man)6 (PP-Dol)1 | Metabolite | kegg.glycan:G10595 | |
| L-Asparagine | Metabolite | chebi:17196 | Sometimes referred to as 'Asn-X-Ser/Thr' because oligosaccharyltransferase (OST) selects the Asn-X-Ser/Thr consensus sequence on polypeptide chains |
| (Glc)2 (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | kegg.glycan:G00171 | |
| B4GALT3 | GeneProduct | ensembl:ENSOARG00000009668 | Sometimes referred to as: - Beta-1,4-galactosyltransferase 3 |
| MGAT4A | GeneProduct | ensembl:ENSOARG00000013496 | Sometimes referred to as: - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X2 - alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A |
| MGAT1 | GeneProduct | ensembl:ENSOARG00000016716 | Sometimes referred to as: - Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
| ALG13 | GeneProduct | ensembl:ENSOARG00000017633 | Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X1. |
| MAN1C1 | GeneProduct | ensembl:ENSOARG00000005906 | Sometimes referred to as: - Mannosidase alpha class 1C member 1 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1 - Alpha-1,2-Mannosidase |
| ALG5 | GeneProduct | ensembl:ENSOARG00000010275 | Sometimes referred to as: - ALG5 dolichyl-phosphate beta-glucosyltransferase - Dolichyl-phosphate beta-glucosyltransferase |
| LOC114113140 | GeneProduct | uniprot:A0A6P7DPQ4 | Sometimes referred to as: - Sialyltransferase 1 - Beta-galactoside alpha-2,6-sialyltransferase 1-like |
| RPN1 | GeneProduct | ncbiprotein:XP_027813657 | Sometimes referred to as: - Ribophorin I - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 - Oligosaccharyltransferase complex subunit alpha |
| ALG3 | GeneProduct | ensembl:ENSOARG00000020606 | Sometimes referred to as: - Alpha-1,3-mannosyltransferase - Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase - ALG3 alpha-1,3- mannosyltransferase |
| MGAT4C | GeneProduct | uniprot:A0A6P7DXD1 | Sometimes referred to as: - MGAT4 family member C - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C - Alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C |
| MAN1A1 | GeneProduct | ensembl:ENSOARG00000008408 | Sometimes referred to as: - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA - Mannosyl-oligosaccharide alpha-1,2-mannosidase - Mannosidase alpha class 1A member 1 - Alpha-1,2-Mannosidase |
| STT3A | GeneProduct | ensembl:ENSOARG00000011533 | Sometimes referred to as: - STT3 oligosaccharyltransferase complex catalytic subunit A - dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X3 - Dolichyl-diphosphooligosaccharide--protein glycotransferase |
| ALG11 | GeneProduct | ncbiprotein:XP_004012140 | Sometimes referred to as: - GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase - Alpha-1,2-mannosyltransferase |
| B4GALT1 | GeneProduct | ensembl:ENSOARG00000009544 | Sometimes referred to as: - Beta-1,4-galactosyltransferase 1 |
| ALG14 | GeneProduct | ncbiprotein:XP_027828046 | Sometimes referred to as: - UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1 - beta-1,4-N-acetylglucosaminyltransferase |
| MAN1A2 | GeneProduct | ensembl:ENSOARG00000020315 | Sometimes referred to as: - Mannosidase alpha class 1A member 2 - Alpha-1,2-Mannosidase - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB - Mannosyl-oligosaccharide alpha-1,2-mannosidase |
| ALG12 | GeneProduct | ensembl:ENSOARG00000019629 | Sometimes referred to as: - Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase - Alpha-1,6-mannosyltransferase - ALG12 alpha-1,6-mannosyltransferase |
| ST6GAL2 | GeneProduct | uniprot:A0A6P7DVZ4 | Sometimes referred to as: - Beta-galactoside alpha-2,6-sialyltransferase 2 - Beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1 |
| MAN2A2 | GeneProduct | ensembl:ENSOARG00000012575 | Sometimes referred to as: - Alpha-mannosidase II - Alpha-mannosidase 2x isoform X1 - Mannosidase alpha class 2A member 2 |
| ALG2 | GeneProduct | ncbiprotein:XP_004004274 | Sometimes referred to as: - alpha-1,3/1,6-mannosyltransferase ALG2 - alpha-1,3/alpha-1,6-mannosyltransferase |
| STT3B | GeneProduct | ensembl:ENSOARG00000014854 | Sometimes referred to as: - STT3 oligosaccharyltransferase complex catalytic subunit B - dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B - Dolichyl-diphosphooligosaccharide--protein glycotransferase |
| MOGS | GeneProduct | ensembl:ENSOARG00000012692 | Sometimes referred to as: - Mannosyl-oligosaccharide glucosidase |
| ALG8 | GeneProduct | ensembl:ENSOARG00000006601 | Sometimes referred to as: - Alpha-1,3-glucosyltransferase - ALG8 alpha-1,3-glucosyltransferase |
| DAD1 | GeneProduct | ensembl:ENSOARG00000019440 | Sometimes referred to as: - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 - Oligosaccharyltransferase complex subunit epsilon - Defender against cell death 1 |
| MGAT3 | GeneProduct | uniprot:A0A6P7DZW7 | Sometimes referred to as: - Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase - Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X3 |
| MGAT2 | GeneProduct | ensembl:ENSOARG00000000832 | Sometimes referred to as: - Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
| ALG1 | GeneProduct | ensembl:ENSOARG00000005002 | Sometimes referred to as: - chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X1 - chitobiosyldiphosphodolichol beta-mannosyltransferase |
| MGAT4B | GeneProduct | ensembl:ENSOARG00000002936 | Sometimes referred to as: - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform X1 - Alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B |
| ALG9 | GeneProduct | ensembl:ENSOARG00000014873 | |
| MGAT4D | GeneProduct | ensembl:ENSOARG00000012558 | Sometimes referred to as: - MGAT4 family member D - alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D |
| TUSC3 | GeneProduct | ensembl:ENSOARG00000009678 | Sometimes referred to as: - Tumor suppressor candidate 3 isoform X4 - Oligosaccharyltransferase complex subunit gamma |
| ALG6 | GeneProduct | ensembl:ENSOARG00000009650 | Sometimes referred to as: - ALG6 alpha-1,3-glucosyltransferase - Alpha-1,3-glucosyltransferase |
| RPN2 | GeneProduct | ensembl:ENSOARG00000017801 | Sometimes referred to as: - Ribophorin II - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2 - Oligosaccharyltransferase complex subunit delta |
| ALG10 | GeneProduct | ensembl:ENSOARG00000019292 | Sometimes referred to as: - dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase - alpha-1,2-glucosyltransferase - ALG10 alpha-1,2-glucosyltransferase |
| GANAB | GeneProduct | ensembl:ENSOARG00000015910 | Sometimes referred to as: - Neutral alpha-glucosidase AB isoform X1 - Mannosyl-oligosaccharide alpha-1,3-glucosidase - Glucosidase II alpha subunit |
| MGAT5B | GeneProduct | ensembl:ENSOARG00000006412 | Sometimes referred to as: - Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X1 - Mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B - alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B |
| MGAT5 | GeneProduct | ensembl:ENSOARG00000011436 | Sometimes referred to as: - Alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase - Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A |
| DDOS | GeneProduct | ensembl:ENSOARG00000009017 | Sometimes referred to as: - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
| ST6GAL1 | GeneProduct | ensembl:ENSOARG00000020506 | Sometimes referred to as: - Beta-galactoside alpha-2,6-sialyltransferase 1 - ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
| FUT8 | GeneProduct | ensembl:ENSOARG00000021160 | Sometimes referred to as: - Fucosyltransferase 8 - Alpha-(1,6)-fucosyltransferase |
| MAN1B1 | GeneProduct | uniprot:A0A6P7DSV8 | Sometimes referred to as: - Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 - Endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase - Alpha-1,2-Mannosidase |
| Dolichyldiphosphatase | Protein | ncbiprotein:XP_027822123 | Sometimes referred to as: - DOLPP1 - Dolichyldiphosphatase 1 isoform X5 |
| DPAGT1 | Protein | ensembl:ENSOARG00000013201 | Sometimes referred to as: - Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 - UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1 - ALG7 (=gene) |
| DMP2 | Protein | ensembl:ENSOARG00000011136 | Sometimes referred to as: - Dolichol phosphate-mannose biosynthesis regulatory protein - Dolichyl-phosphate mannosyltransferase subunit 2 |
| DMP3 | Protein | ensembl:ENSOARG00000006665 | Sometimes referred to as: - Dolichol-phosphate mannosyltransferase subunit 3 |
| Dolichol Kinase | Protein | ensembl:ENSOARG00000019081 | Sometimes referred to as: - DOLK |
| DPM1 | Protein | ensembl:ENSOARG00000013988 | Sometimes referred to as: - Dolichol-phosphate mannosyltransferase subunit 1 |
| Polyprenol Reductase | Protein | ensembl:ENSOARG00000001390 | Also referred to as: - Steroid 5 alpha-reductase 3 - 3-oxo-5-alpha-steroid 4-dehydrogenase 3 - polyprenol reductase isoform X3 From gene: - SRD5A3 |
References
- The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum. Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N. J Biol Chem. 2001 Jun 15;276(24):21828–40. PubMed Europe PMC Scholia
- Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions. Roth J. Chem Rev. 2002 Feb;102(2):285–303. PubMed Europe PMC Scholia
- Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P. Mol Biol Evol. 2002 Sep;19(9):1451–63. PubMed Europe PMC Scholia
- A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis. Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, et al. J Biol Chem. 2003 Jun 20;278(25):22498–505. PubMed Europe PMC Scholia
- ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis. Frank CG, Aebi M. Glycobiology. 2005 Nov;15(11):1156–63. PubMed Europe PMC Scholia
- In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. O’Reilly MK, Zhang G, Imperiali B. Biochemistry. 2006 Aug 8;45(31):9593–603. PubMed Europe PMC Scholia
- N-linked protein glycosylation in the endoplasmic reticulum. Breitling J, Aebi M. Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a013359. PubMed Europe PMC Scholia