Serotonin HTR1 group and FOS pathway (WP722)
Homo sapiens
This pathway depicts the downstream signaling of serotonin via the receptors 1 group, resulting in the production of FOS via ELK-SRF and CREB1. This pathway also shows the downstream signaling of serotonin via receptor 2A, resulting in the activation of STAT3.
Authors
Ruke Achoja , Kristina Hanspers , Alex Pico , Thomas Kelder , Andra Waagmeester , Egon Willighagen , Friederike Ehrhart , Eric Weitz , and Denise SlenterActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
serotonin signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
1,2-Diacetin | Metabolite | cas:102-62-5 | diacylglycerol |
PtdIns3P | Metabolite | chebi:57836 | phosphatidylinositol 3,4,5-triphosphate |
1,4,5-Insp3 | Metabolite | cas:85166-31-0 | |
CALCIUM | Metabolite | cas:7440-70-2 | |
Serotonin | Metabolite | hmdb:HMDB0000259 | |
PtdIns2P | Metabolite | chebi:58456 | phosphatidylinositol 4,5-diphosphate |
PKC | GeneProduct | ncbigene:50818 | protein kinase C |
ELK1 | GeneProduct | ncbigene:2002 | ELK1, member of ETS oncogene family |
RASGRF1 | GeneProduct | ncbigene:5923 | RAS protein-specific guanine nucleotide-releasing factor 1 |
MAP2K6 | GeneProduct | ncbigene:5608 | mitogen activated protein kinase kinase 6 |
MAPK3 | GeneProduct | ncbigene:5595 | mitogen activated protein kinase 3 |
PDPK1 | GeneProduct | ncbigene:5170 | 3-phosphoinositide dependent protein kinase-1 |
RASGRP1 | GeneProduct | ncbigene:10125 | RAS guanyl releasing protein 1 |
RHOA | GeneProduct | ncbigene:387 | ras homolog gene family, member A |
RAP1A | GeneProduct | ncbigene:5906 | RAS-related protein-1a |
PI3K | GeneProduct | ncbigene:5290 | phosphatidylinositol 3-kinase |
RPS6KA5 | GeneProduct | ncbigene:9252 | ribosomal protein S6 kinase, polypeptide 5 |
MAP2K1 | GeneProduct | ncbigene:5604 | mitogen activated protein kinase kinase 1 |
SRF | GeneProduct | ncbigene:6722 | serum response factor |
ELK4 | GeneProduct | ncbigene:2005 | ETS domain-containing protein Elk-4 (SRF accessory protein 1) |
PLC | GeneProduct | eccode:3.1.4.11 | phospholipase C |
MAPKAPK3 | GeneProduct | ncbigene:7867 | mitogen-activated protein kinase-activated protein kinase 3 |
CREB1 | GeneProduct | ncbigene:1385 | cAMP response element-binding protein 1 |
BRAF | GeneProduct | ncbigene:673 | v-raf murine sarcoma viral oncogene homolog B1 |
MAPKAPK2 | GeneProduct | ncbigene:9261 | mitogen activated protein kinase 3 |
MAP2K2 | GeneProduct | ncbigene:5605 | mitogen activated protein kinase kinase 2 |
MAPK14 | GeneProduct | ncbigene:1432 | mitogen activated protein kinase 14 |
MAP3K1 | GeneProduct | ncbigene:4214 | mitogen activated protein kinase kinase kinase 1 |
FOS | GeneProduct | ncbigene:2353 | proto-oncogene protein c-fos |
ITPR1 | GeneProduct | ncbigene:3708 | inositol 1,4,5-triphosphate receptor 1 |
MAP2K3 | GeneProduct | ncbigene:5606 | mitogen activated protein kinase kinase 3 |
MAPK1 | GeneProduct | hgnc.symbol:MAPK1 | mitogen activated protein kinase 1 |
HTR2A | GeneProduct | ncbigene:3356 | 5-hydroxytryptamine (serotonin) receptor 2A |
JAK2 | GeneProduct | ncbigene:3717 | Janus kinase 2 |
GNAQ | GeneProduct | ncbigene:2776 | guanine nucleotide binding protein, alpha q polypeptide |
STAT3 | GeneProduct | ncbigene:6774 | signal transducer and activator of transcription |
GNAI1 | Protein | ncbigene:2770 | |
GNAI2 | Protein | ncbigene:2771 | |
HTR1D | Protein | ncbigene:3352 | |
HTR1A | Protein | ncbigene:3350 | |
HTR1B | Protein | ncbigene:3351 | |
GNAO1 | Protein | ncbigene:2775 | |
GNAI3 | Protein | ncbigene:2773 | |
HTR1E | Protein | ncbigene:3354 | |
HTR1F | Protein | ncbigene:3355 |
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- Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cdelta /Ras/MEKK1/MKK1-dependent/AP-1 signal transduction pathway. Vuong H, Patterson T, Shapiro P, Kalvakolanu DV, Wu R, Ma WY, et al. J Biol Chem. 2000 Oct 13;275(41):32250–9. PubMed Europe PMC Scholia
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- Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, et al. J Biol Chem. 2000 Nov 24;275(47):36532–40. PubMed Europe PMC Scholia
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- Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. Zhang BH, Guan KL. EMBO J. 2000 Oct 16;19(20):5429–39. PubMed Europe PMC Scholia
- Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. Monick MM, Carter AB, Flaherty DM, Peterson MW, Hunninghake GW. J Immunol. 2000 Oct 15;165(8):4632–9. PubMed Europe PMC Scholia
- MEK inhibition enhances paclitaxel-induced tumor apoptosis. MacKeigan JP, Collins TS, Ting JP. J Biol Chem. 2000 Dec 15;275(50):38953–6. PubMed Europe PMC Scholia
- Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells. Chung KC, Sung JY, Ahn W, Rhim H, Oh TH, Lee MG, et al. J Biol Chem. 2001 Jan 19;276(3):2132–8. PubMed Europe PMC Scholia
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- Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent. Swarthout JT, Doggett TA, Lemker JL, Partridge NC. J Biol Chem. 2001 Mar 9;276(10):7586–92. PubMed Europe PMC Scholia
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- The information content of spontaneous retinal waves. Butts DA, Rokhsar DS. J Neurosci. 2001 Feb 1;21(3):961–73. PubMed Europe PMC Scholia
- Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Morgan MA, Dolp O, Reuter CW. Blood. 2001 Mar 15;97(6):1823–34. PubMed Europe PMC Scholia
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- Basic fibroblast growth factor-induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells. Sung JY, Shin SW, Ahn YS, Chung KC. J Biol Chem. 2001 Apr 27;276(17):13858–66. PubMed Europe PMC Scholia
- Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways. Garcia J, de Gunzburg J, Eychène A, Gisselbrecht S, Porteu F. Mol Cell Biol. 2001 Apr;21(8):2659–70. PubMed Europe PMC Scholia
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- Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. Kim HL, Vander Griend DJ, Yang X, Benson DA, Dubauskas Z, Yoshida BA, et al. Cancer Res. 2001 Apr 1;61(7):2833–7. PubMed Europe PMC Scholia
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- A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. Knebel A, Morrice N, Cohen P. EMBO J. 2001 Aug 15;20(16):4360–9. PubMed Europe PMC Scholia
- Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG. EMBO J. 2001 Aug 15;20(16):4370–9. PubMed Europe PMC Scholia
- Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. Gnesutta N, Ceriani M, Innocenti M, Mauri I, Zippel R, Sturani E, et al. J Biol Chem. 2001 Oct 19;276(42):39448–54. PubMed Europe PMC Scholia
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- Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Guha M, O’Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, et al. Blood. 2001 Sep 1;98(5):1429–39. PubMed Europe PMC Scholia
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- A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK. Inoue H, Tateno M, Fujimura-Kamada K, Takaesu G, Adachi-Yamada T, Ninomiya-Tsuji J, et al. EMBO J. 2001 Oct 1;20(19):5421–30. PubMed Europe PMC Scholia
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