MicroRNAs in cardiomyocyte hypertrophy (WP1544)

Homo sapiens

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This pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lines. MicroRNAs are shown as purple rounded rectangles. It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1544 CPTAC Assay Portal]

Authors

Maartje Levels , Martijn Van Iersel , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Alex Pico , Egon Willighagen , Susan Coort , Friederike Ehrhart , Marvin Martens , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

hypertrophic cardiomyopathy pathway microRNA pathway

Disease Ontology

heart disease

Participants
Query Drugst.One

Label Type Compact URI Comment
Calcium Metabolite hmdb:HMDB0000464
Cyclic GMP Metabolite hmdb:HMDB0001314
IP3 Metabolite hmdb:HMDB0001498
DAG Metabolite hmdb:HMDB0007009
hsa-mir-199a-1 GeneProduct ensembl:ENSG00000207752
hsa-mir-15b GeneProduct ensembl:ENSG00000207779
WNT3A GeneProduct ncbigene:89780
hsa-mir-103-2-as GeneProduct ensembl:ENSG00000199024
STAT3 GeneProduct ncbigene:6774
ERK1 GeneProduct ncbigene:5595
hsa-mir-125b-2 GeneProduct ensembl:ENSG00000207863
hsa-mir-23a GeneProduct ensembl:ENSG00000207980
LIF GeneProduct ncbigene:3976
MLCK3 GeneProduct ncbigene:91807
hsa-mir-30e GeneProduct ensembl:ENSG00000198974
hsa-mir-195 GeneProduct ensembl:ENSG00000284112
RCAN1 GeneProduct ncbigene:1827
PRKCB GeneProduct ncbigene:5579
hsa-mir-21 GeneProduct ensembl:ENSG00000284190
MAPKKK GeneProduct ncbigene:5595
hsa-mir-130b GeneProduct ensembl:ENSG00000283871
hsa-let-7b GeneProduct ensembl:ENSG00000284520
RAC1 GeneProduct ncbigene:5879
HDAC 4 GeneProduct ncbigene:9759
HDAC 9 GeneProduct ncbigene:9734
PDK GeneProduct ncbigene:5170
IGFI GeneProduct ncbigene:3479
hsa-mir-199a-2 GeneProduct ensembl:ENSG00000208024
JNK GeneProduct ncbigene:5599
ERK2 GeneProduct ncbigene:5594
hsa-mir-133b GeneProduct ensembl:ENSG00000199080
CHUK GeneProduct ncbigene:1147
hsa-mir-125b-1 GeneProduct ensembl:ENSG00000207971
CDK 7 GeneProduct ncbigene:1022
hsa-mir-140 GeneProduct ensembl:ENSG00000208017
hsa-mir-133a-1 GeneProduct ensembl:ENSG00000283927
CTNNB1 GeneProduct ncbigene:1499
IKBKG GeneProduct ncbigene:8517
AGT GeneProduct ncbigene:183
DVL1 GeneProduct ncbigene:1855
NFAT3 GeneProduct ncbigene:4776
GSK3B GeneProduct ncbigene:2932
ERK5 GeneProduct ncbigene:5598
PIK3CA GeneProduct ncbigene:5290
CTF1 GeneProduct ncbigene:1489
MEK2 GeneProduct ncbigene:5605
hsa-mir-208a GeneProduct ensembl:ENSG00000199157
PIK3R1 GeneProduct ncbigene:5295
hsa-mir-27b GeneProduct ensembl:ENSG00000207864
PIK3R2 GeneProduct ncbigene:5296
MEK4 GeneProduct ncbigene:6416
NFKB1 GeneProduct ncbigene:4790
hsa-mir-133a-2 GeneProduct ensembl:ENSG00000284508
hsa-mir-103-1-as GeneProduct ensembl:ENSG00000199035
IGF-1 R GeneProduct ncbigene:3480
NIK GeneProduct ncbigene:9020
HDAC 7 GeneProduct ncbigene:51564
SOCS GeneProduct ncbigene:1154
ROCK1 GeneProduct ncbigene:6093
PDK1 GeneProduct ncbigene:5170
hsa-mir-185 GeneProduct ensembl:ENSG00000208023
CDK 9 GeneProduct ncbigene:1025
PRKG1 GeneProduct ncbigene:5592
PIK3CD GeneProduct ncbigene:5293
PLC GeneProduct ncbigene:5330
IKBKE GeneProduct ncbigene:9641
MAPK14 GeneProduct ncbigene:1432
FGFR2 GeneProduct ncbigene:2263
MLCK1 GeneProduct ncbigene:4638
hsa-mir-214 GeneProduct ensembl:ENSG00000283844
RAF1 GeneProduct ncbigene:5894
EDN1 GeneProduct ncbigene:1906
IKBKB GeneProduct ncbigene:3551
IL6ST GeneProduct ncbigene:3572
MEK7 GeneProduct ncbigene:5609
PIK3CB GeneProduct ncbigene:5291
PIK3R3 GeneProduct ncbigene:8503
Neuregulin GeneProduct ncbigene:3084
EGF GeneProduct ncbigene:1950
MYEF2 GeneProduct ncbigene:50804
PPP3CB GeneProduct ncbigene:5532
AKT2 GeneProduct ncbigene:208
TGFB1 GeneProduct ncbigene:7040
MTOR GeneProduct ncbigene:2475
FGF2 GeneProduct ncbigene:2247
MEK3 GeneProduct ncbigene:5606
Ang II GeneProduct ncbigene:183
MAPKKKK GeneProduct ncbigene:5596
MEK5 GeneProduct ncbigene:5607
ANP GeneProduct ncbigene:4878
PLA2 GeneProduct ncbigene:5320
PIK3CG GeneProduct ncbigene:5294
TNF GeneProduct ncbigene:7124
ROCK2 GeneProduct ncbigene:9475
MEK1 GeneProduct ncbigene:5604
BNP GeneProduct ncbigene:4879
HDAC 5 GeneProduct ncbigene:10014
RHOA GeneProduct ncbigene:387
WNT5A GeneProduct ncbigene:7474
GATA4 GeneProduct ncbigene:2626
EIF2B5 GeneProduct ncbigene:8893
AKT1 GeneProduct ncbigene:207
PPP3CA GeneProduct ncbigene:5530
CAMK2D GeneProduct ncbigene:817
TAK1 GeneProduct ncbigene:10454
MEK6 GeneProduct ncbigene:5608
FZD2 GeneProduct ncbigene:2535
LRP5 GeneProduct ncbigene:4041
LRP6 GeneProduct ncbigene:4040
FZD1 GeneProduct ncbigene:8321
CALM1 Protein ncbigene:801

References

  1. Calcineurin and human heart failure. Lim HW, Molkentin JD. Nat Med. 1999 Mar;5(3):246–7. PubMed Europe PMC Scholia
  2. The PI3K-PDK1 connection: more than just a road to PKB. Vanhaesebroeck B, Alessi DR. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):561–76. PubMed Europe PMC Scholia
  3. Regulation of cardiac hypertrophy by intracellular signalling pathways. Heineke J, Molkentin JD. Nat Rev Mol Cell Biol. 2006 Aug;7(8):589–600. PubMed Europe PMC Scholia
  4. MicroRNA-133 controls cardiac hypertrophy. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, et al. Nat Med. 2007 May;13(5):613–8. PubMed Europe PMC Scholia
  5. The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy. Blankesteijn WM, van de Schans VAM, ter Horst P, Smits JFM. Trends Pharmacol Sci. 2008 Apr;29(4):175–80. PubMed Europe PMC Scholia
  6. MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart. Wang J, Xu R, Lin F, Zhang S, Zhang G, Hu S, et al. Cardiology. 2009;113(2):81–8. PubMed Europe PMC Scholia
  7. STAT3 and cardiac remodeling. Haghikia A, Stapel B, Hoch M, Hilfiker-Kleiner D. Heart Fail Rev. 2011 Jan;16(1):35–47. PubMed Europe PMC Scholia