Acetylcholine synthesis (WP1034)

Bos taurus

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Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.

Authors

Thomas Kelder , Christine Chichester , Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , Asios Olia , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

acetylcholine metabolic pathway

Participants

Label Type Compact URI Comment
Cytidine diphosphate choline Metabolite hmdb:HMDB0001413
Phosphatidylethanolamine Metabolite hmdb:HMDB0060501
Phosphorylcholine Metabolite hmdb:HMDB0001565
Acetylcholine Metabolite cas:51-84-3
Choline Metabolite cas:62-49-7
Glycerophosphocholine Metabolite cas:28319-77-9
Phosphatidylcholine Metabolite hmdb:HMDB0000564
Pyruvate from Glycolysis Metabolite hmdb:HMDB0000243
Acetyl CoA Metabolite cas:72-89-9
Acetate Metabolite cas:64-19-7
PCYT1A GeneProduct ensembl:ENSBTAG00000016979 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5130
PDHA2 GeneProduct ensembl:ENSBTAG00000026250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5161
ACHE GeneProduct ensembl:ENSBTAG00000001139 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:43
PDHA1 GeneProduct ensembl:ENSBTAG00000019852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5160
PEMT GeneProduct ensembl:ENSBTAG00000016432 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10400
CHKA GeneProduct ensembl:ENSBTAG00000010304 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1119
CHAT GeneProduct ensembl:ENSBTAG00000016814 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1103

References

  1. Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. PubMed Europe PMC Scholia
  2. Acetylcholine synthesis and possible functions during sea urchin development. Angelini C, Baccetti B, Piomboni P, Trombino S, Aluigi MG, Stringara S, et al. Eur J Histochem. 2004;48(3):235–43. PubMed Europe PMC Scholia
  3. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, Pawełczyk T, Ronowska A. Neurochem Res. 2013 Aug;38(8):1523–42. PubMed Europe PMC Scholia