Hippocampal synaptogenesis and neurogenesis (WP5231)

Homo sapiens

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Cognitive function and the consolidation of memory through hippocampal synaptogenesis and neurogenesis and the role of thyroxine.

Authors

Celine Malyar , Egon Willighagen , Alex Pico , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

hippocampal neuron

Pathway Ontology

signaling pathway pertinent to development signaling pathway regulatory pathway synaptic differentiation pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ATP Metabolite chebi:30616
Ca2+ Metabolite chebi:29108
Thyroxine (T4) Metabolite hmdb:HMDB0000248
cAMP Metabolite chebi:17489
Na+ Metabolite chebi:29101
K+ Metabolite chebi:29103
Triiodothyronine (T3) Metabolite chemspider:5707
DRD1 GeneProduct ensembl:ENSG00000184845
TrkB GeneProduct uniprot:W8VY28
PRKCA Protein hgnc.symbol:HGNC:9393
CREB1 Protein uniprot:P16220
CALM1 Protein ensembl:ENSG00000198668
CAMK2A Protein ensembl:ENSG00000070808
CAMK2B Protein ensembl:ENSG00000058404
CAMKK1 Protein ensembl:ENSG00000004660
CAMKK2 Protein ensembl:ENSG00000110931
CAMK4 Protein ensembl:ENSG00000152495
CAMK4 Protein hgnc.symbol:HGNC:1464
PRKCA Protein ensembl:ENSG00000154229
MAPK14 Protein ensembl:ENSG00000112062
MAPK/ERK Protein ensembl:ENSG00000100030
RSK Protein ensembl:ENSG00000117676
RPS6KA5 Protein ensembl:ENSG00000100784
DIO2 Protein ensembl:ENSG00000211448
NRXN1 Protein ensembl:ENSG00000179915
NRXN2 Protein ensembl:ENSG00000110076
NRXN3 Protein ensembl:ENSG00000021645
SYT2 Protein ensembl:ENSG00000143858
SYT12 Protein ensembl:ENSG00000173227
BDNF Protein ensembl:ENSG00000176697
NCAM1 Protein ensembl:ENSG00000149294
PRL Protein ensembl:ENSG00000172179
BCL2 Protein ensembl:ENSG00000171791
NGF None Protein
CCND2 Protein ensembl:ENSG00000118971
HNRNPL Protein ensembl:ENSG00000104824
PPARGC1A Protein ensembl:ENSG00000109819

References

  1. A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis. Ortega-Martínez S. Front Mol Neurosci. 2015 Aug 26;8:46. PubMed Europe PMC Scholia
  2. Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway. Krebs J. Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):877–82. PubMed Europe PMC Scholia
  3. The Influence of Thyroid Hormone on Ca2+ Signaling Pathways During Embryonal Development. Krebs J. Curr Top Med Chem. 2021;21(13):1121–8. PubMed Europe PMC Scholia