Omega-9 fatty acid synthesis (WP4724)
Homo sapiens
New PW, homology converted
Authors
Denise Slenter and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
fatty acid elongation pathway fatty acid metabolic pathway unsaturated fatty acid biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CoA(20:0) | Metabolite | lipidmaps:LMFA07050329 | |
| Lauric acid | Metabolite | lipidmaps:LMFA01010012 | |
| Myristic acid | Metabolite | lipidmaps:LMFA01010014 | |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 | |
| CoA(16:1(9Z)) | Metabolite | lipidmaps:LMFA07050359 | |
| CoA(18:1(9Z)) | Metabolite | lipidmaps:LMFA07050356 | |
| CoA(18:2(6Z,9Z)) | Metabolite | lipidmaps:LMFA07050060 | |
| CoA(20:1(11Z)) | Metabolite | lipidmaps:LMFA07050093 | |
| CoA(20:2(8Z,11Z)) | Metabolite | lipidmaps:LMFA07050061 | |
| 18:2(6Z,9Z) | Metabolite | lipidmaps:LMFA07050060 | |
| Stearic acid | Metabolite | lipidmaps:LMFA01010018 | |
| 16:1(9Z) | Metabolite | lipidmaps:LMFA01030056 | |
| CoA(18:0) | Metabolite | lipidmaps:LMFA07050369 | |
| Palmitic acid | Metabolite | lipidmaps:LMFA01010001 | |
| CoA(22:0) | Metabolite | lipidmaps:LMFA07050289 | |
| CoA(24:0) | Metabolite | lipidmaps:LMFA07050372 | |
| CoA(26:0) | Metabolite | lipidmaps:LMFA07050327 | |
| Arachidic acid | Metabolite | lipidmaps:LMFA01010020 | |
| Behenic acid | Metabolite | lipidmaps:LMFA01010022 | |
| Lignoceric acid | Metabolite | lipidmaps:LMFA01010024 | |
| Cerotic acid | Metabolite | lipidmaps:LMFA01010026 | |
| CoA(22:1(13Z)) | Metabolite | lipidmaps:LMFA07050318 | |
| CoA(24:1(15Z)) | Metabolite | lipidmaps:LMFA07050098 | |
| 20:2(8Z,11Z) | Metabolite | lipidmaps:LMFA01030377 | |
| CoA(20:3(5Z,8Z,11Z)) | Metabolite | lipidmaps:LMFA07050062 | |
| 20:3(5Z,8Z,11Z) | Metabolite | lipidmaps:LMFA01030381 | |
| Oleic acid | Metabolite | lipidmaps:LMFA01030002 | |
| 24:1(15Z)) | Metabolite | lipidmaps:LMFA01030377 | AKA cis-selacholeic acid |
| cis-erucic acid | Metabolite | cas:112-86-7 | AKA cis-selacholeic acid |
| FADS1 | GeneProduct | ensembl:ENSG00000149485 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267 |
| ACSL1 | GeneProduct | ensembl:ENSG00000151726 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081 |
| FASN | GeneProduct | ensembl:ENSG00000169710 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14104 |
| ACSL3 | GeneProduct | ensembl:ENSG00000123983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205 |
| ACSL4 | GeneProduct | ensembl:ENSG00000068366 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 |
| ELOVL2 | GeneProduct | ensembl:ENSG00000197977 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326 |
| ELOVL5 | GeneProduct | ensembl:ENSG00000012660 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801 |
| ELOVL6 | GeneProduct | ensembl:ENSG00000170522 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:170439 |
| ELOVL3 | GeneProduct | ensembl:ENSG00000119915 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12686 |
| ELOVL1 | GeneProduct | ensembl:ENSG00000066322 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54325 |
| FADS2 | GeneProduct | ensembl:ENSG00000134824 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 |
| ACOT2 | GeneProduct | ensembl:ENSG00000119673 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210 |
| SCD5 | Protein | uniprot:Q86SK9 | AKA SCD2, hSCD2. Soucre: [https://www.uniprot.org/uniprot/Q86SK9].'highly expressed in brain' [PMID:22745828]; 'most abundantly expressed in pancreas and brain' [PMID:15610069], 'transcripts from adult and foetal tissues exhibit different sizes because of alternative splicing in the non-coding region, suggesting that hSCD2 (aka SCD5, red.) expression is developmentally regulated.' [PMID:15610069] |
| hSCD1 | Protein | uniprot:O00767 | No homologues found for original id L:20250 (Scd2) Human ortholog is SCD, which had mouse orthologs Scd2 and Scd4.'SCD catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA' Source:[https://www.uniprot.org/uniprot/O00767].'predominantly expressed in liver' [PMID:15610069]. |
References
- Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Zhang S, Yang Y, Shi Y. Biochem J. 2005 May 15;388(Pt 1):135–42. PubMed Europe PMC Scholia
- Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, et al. Biochem Biophys Res Commun. 2005 Jul 8;332(3):735–42. PubMed Europe PMC Scholia
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia