Oxidative phosphorylation (WP623)

Homo sapiens

Authors

Andra Waagmeester , Martijn Van Iersel , Kristina Hanspers , Alex Pico , Allan Kuchinsky , Zahra Roudbari , Martina Summer-Kutmon , Denise Slenter , Egon Willighagen , Friederike Ehrhart , and Eric Weitz

Activity

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Cited In

• A Pilot Mitochondrial Genome-Wide Association on Migraine Among Saudi Arabians (2022).
• DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
• Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype (2020).
• Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia (2019).
• Pathway analysis of transcriptomic data shows immunometabolic effects of vitamin D (2018).
• Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis (2017).
• A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
• Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).

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Organisms

Homo sapiens

Communities

ONTOX Serious Request 2024 - MetaKids

Annotations

Pathway Ontology

oxidative phosphorylation pathway

References

1. Keilin’s respiratory chain concept and its chemiosmotic consequences. Mitchell P. Science. 1979 Dec 7;206(4423):1148–59. PubMed Europe PMC Scholia
2. The structure, function and evolution of cytochromes. Mathews FS. Prog Biophys Mol Biol. 1985;45(1):1–56. PubMed Europe PMC Scholia
3. Chemiosmotic hypothesis of oxidative phosphorylation. Mitchell P, Moyle J. Nature. 1967 Jan 14;213(5072):137–9. PubMed Europe PMC Scholia
4. Chemi-osmotic theory of oxidative phosphorylation. Tager JM, Veldsema-Currie RD, Slater EC. Nature. 1966 Oct 22;212(5060):376–9. PubMed Europe PMC Scholia
5. Mitochondrial proton conductance and H+/O ratio are independent of electron transport rate in isolated hepatocytes. Porter RK, Brand MD. Biochem J. 1995 Sep 1;310 ( Pt 2)(Pt 2):379–82. PubMed Europe PMC Scholia
6. Crucial role of the membrane potential for ATP synthesis by F(1)F(o) ATP synthases. Dimroth P, Kaim G, Matthey U. J Exp Biol. 2000 Jan;203(Pt 1):51–9. PubMed Europe PMC Scholia
7. Structures and proton-pumping strategies of mitochondrial respiratory enzymes. Schultz BE, Chan SI. Annu Rev Biophys Biomol Struct. 2001;30:23–65. PubMed Europe PMC Scholia
8. Biochemical functions of coenzyme Q10. Crane FL. J Am Coll Nutr. 2001 Dec;20(6):591–8. PubMed Europe PMC Scholia
9. The molecular machinery of Keilin’s respiratory chain. Rich PR. Biochem Soc Trans. 2003 Dec;31(Pt 6):1095–105. PubMed Europe PMC Scholia
10. Disturbances of purine nucleotide metabolism in uremia. Rutkowski B, Swierczynski J, Slominska E, Szolkiewicz M, Smolenski RT, Marlewski M, et al. Semin Nephrol. 2004 Sep;24(5):479–83. PubMed Europe PMC Scholia
11. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. Quinton TM, Kim S, Jin J, Kunapuli SP. J Thromb Haemost. 2005 May;3(5):1036–41. PubMed Europe PMC Scholia