Colchicine metabolic pathway (WP2536)

Homo sapiens

P450-mediated biotransformation pathway of colchicine with the CYP3A4, while colchicine inhibits the expression of this enzyme.

Authors

Egon Willighagen and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

phase I biotransformation pathway via cytochrome P450 xenobiotic metabolic pathway

Participants

Label Type Compact URI Comment
Colchicine Metabolite chemspider:5933
3DMC Metabolite chemspider:264748
2DMC Metabolite chemspider:22210
CYP3A4 Protein uniprot:P08684

References

  1. Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ. Biochem Pharmacol. 1997 Jan 10;53(1):111–6. PubMed Europe PMC Scholia
  2. Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, et al. Mol Pharmacol. 2003 Jul;64(1):160–9. PubMed Europe PMC Scholia