Ethanol effects on histone modifications (WP3996)
Homo sapiens
Ethanol effects on histone modifications which contribute to the development of fetal alcohol syndrome. Pathway based on Chater-Diehl et al. 2017 (https://doi.org/10.1016/j.alcohol.2017.01.005). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3996 CPTAC Assay Portal]
Authors
Friederike Ehrhart , Marvin Martens , Kristina Hanspers , and Egon WillighagenActivity
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Organisms
Homo sapiensCommunities
Annotations
Disease Ontology
fetal alcohol spectrum disorderPathway Ontology
altered histone modification pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Homocysteine | Metabolite | hmdb:HMDB0000742 | |
| L-Serine | Metabolite | hmdb:HMDB0000187 | |
| dTMP | Metabolite | hmdb:HMDB0001227 | |
| dUMP | Metabolite | hmdb:HMDB0001409 | |
| S-Adenosylhomocysteine | Metabolite | hmdb:HMDB0000939 | |
| Tetrahydrofolate | Metabolite | chebi:67016 | |
| Folic acid | Metabolite | hmdb:HMDB0000121 | |
| S-Adenosylmethionine | Metabolite | hmdb:HMDB0001185 | |
| Ethanol | Metabolite | hmdb:HMDB0000108 | |
| Nucleic acids | Metabolite | chebi:33696 | |
| L-Methionine | Metabolite | hmdb:HMDB0000696 | |
| Pyrimidines | Metabolite | chebi:39447 | |
| 5,10-MTHF | Metabolite | hmdb:HMDB0001533 | |
| Glycine | Metabolite | hmdb:HMDB0000123 | |
| Dihydrofolate | Metabolite | chebi:15633 | |
| 5-MTHF | Metabolite | hmdb:HMDB0001396 | |
| Acetaldehyde | Metabolite | hmdb:HMDB0000990 | |
| Acetate | Metabolite | chebi:30089 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| Coenzyme A | Metabolite | hmdb:HMDB0001423 | |
| Reactive oxygen species | Metabolite | chebi:26523 | |
| ELP3 | GeneProduct | ensembl:ENSG00000134014 | |
| AHCY | GeneProduct | ensembl:ENSG00000101444 | |
| TYMS | GeneProduct | ensembl:ENSG00000176890 | |
| DHFR | GeneProduct | ensembl:ENSG00000228716 | |
| MTHFR | GeneProduct | ensembl:ENSG00000177000 | |
| EHMT2 | GeneProduct | ensembl:ENSG00000204371 | G9a |
| ATF2 | GeneProduct | ensembl:ENSG00000115966 | |
| HDAC2 | GeneProduct | ensembl:ENSG00000196591 | |
| KAT2B | GeneProduct | ensembl:ENSG00000114166 | also known as PCAF |
| MTR | GeneProduct | ensembl:ENSG00000116984 | |
| MAT1A | GeneProduct | ensembl:ENSG00000151224 | |
| HDAC1 | GeneProduct | ensembl:ENSG00000116478 | |
| HAT1 | GeneProduct | ensembl:ENSG00000128708 | |
| SLC19A1 | GeneProduct | ensembl:ENSG00000173638 | Formerly known as RFC1 |
| ACSS2 | GeneProduct | ensembl:ENSG00000131069 | |
| ADH1B | GeneProduct | ensembl:ENSG00000196616 | |
| CYP2E1 | GeneProduct | ensembl:ENSG00000130649 | |
| ADH1A | GeneProduct | ensembl:ENSG00000187758 | |
| ALDH1A1 | GeneProduct | ensembl:ENSG00000165092 | |
| ALDH2 | GeneProduct | ensembl:ENSG00000111275 | |
| ADH1C | GeneProduct | ensembl:ENSG00000248144 | |
| ALDH1A2 | GeneProduct | ensembl:ENSG00000128918 | |
| ALDH1A3 | GeneProduct | ensembl:ENSG00000184254 | |
| HDAC3 | GeneProduct | ensembl:ENSG00000171720 | |
| HDAC4 | GeneProduct | ensembl:ENSG00000068024 | |
| HDAC5 | GeneProduct | ensembl:ENSG00000108840 | |
| HDAC6 | GeneProduct | ensembl:ENSG00000094631 | |
| HDAC7 | GeneProduct | ensembl:ENSG00000061273 | |
| HDAC8 | GeneProduct | ensembl:ENSG00000147099 | |
| HDAC9 | GeneProduct | ensembl:ENSG00000048052 | |
| HDAC10 | GeneProduct | ensembl:ENSG00000100429 |
References
- Histone acetyltransferase complexes: one size doesn’t fit all. Lee KK, Workman JL. Nat Rev Mol Cell Biol. 2007 Apr;8(4):284–95. PubMed Europe PMC Scholia
- Changes to histone modifications following prenatal alcohol exposure: An emerging picture. Chater-Diehl EJ, Laufer BI, Singh SM. Alcohol. 2017 May;60:41–52. PubMed Europe PMC Scholia