RNA interference and miRNA (WP394)

Caenorhabditis elegans

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RNA interference (RNAi) refers to the silencing of gene expression by the overexpression of sequence-specific RNA molecules. This process is associated with a cellular and nuclear defense mechanism used to combat molecular parasites such as transposons and viruses. In addition, RNA interference has been shown to play a regulatory role in development. Work in C. elegans and other organisms have identified many key regulators and pathways necessary for this process. RNAi has been adapted into a tool for the study of gene function; through the use of RNAi, the expression of a target gene can be inhibited by the reverse engineering of a corresponding dsRNA.

Authors

Martijn Van Iersel , Kristina Hanspers , Karen Yook , and Egon Willighagen

Activity

last edited

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Organisms

Caenorhabditis elegans

Communities

WormBase

Annotations

Pathway Ontology

small non-coding RNA pathway

Participants

Label Type Compact URI Comment
ego-1 GeneProduct ensembl:WBGene00001214
rde-1 GeneProduct ensembl:WBGene00004323
lin-4 GeneProduct ensembl:WBGene00002993
DCR-1/Dicer GeneProduct ensembl:WBGene00000939
rrf-2 GeneProduct ensembl:WBGene00004509
lin-41 GeneProduct ensembl:WBGene00003026
lin-14 GeneProduct ensembl:WBGene00003003
ALG-2 GeneProduct ensembl:WBGene00000106
tsn-1 GeneProduct ensembl:WBGene00006626
PASH-1/DGCR8 GeneProduct ensembl:WBGene00011908
rde-4 GeneProduct ensembl:WBGene00004326
vig-1 GeneProduct ensembl:WBGene00006924
RDE-3/MUT-2 GeneProduct ensembl:WBGene00003499
lin-28 GeneProduct ensembl:WBGene00003014
DRSH-1/Drosha GeneProduct ensembl:WBGene00009163
mut-16 GeneProduct ensembl:WBGene00003508
RDE-2/MUT-8 GeneProduct ensembl:WBGene00004324
ALG-1 GeneProduct ensembl:WBGene00000105
rrf-1 GeneProduct ensembl:WBGene00004508
let-7 GeneProduct ensembl:WBGene00002285
ppw-1 GeneProduct wormbase:C18E3.7
mut-7 GeneProduct ensembl:WBGene00003504
rrf-3 GeneProduct ensembl:WBGene00004510

References