Mitochondrial complex I inhibition leading to parkinsonian motor deficits (WP4945)

Homo sapiens

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This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway (AOP) of Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits AOP-Wiki:3. All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.

Authors

Marvin Martens , Eric Weitz , Finterly Hu , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Adverse Outcome Pathways Diseases ONTOX

Annotations

Disease Ontology

Parkinson's disease

Pathway Ontology

altered energy metabolic pathway

Participants

Label Type Compact URI Comment

References

  1. An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition. Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, EFSA WG EPI1 Members, et al. Arch Toxicol. 2018 Jan;92(1):41–82. PubMed Europe PMC Scholia