LDLRAD4 and what we know about it (WP4904)

Homo sapiens

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A recent GWAS study was tweeted (https://twitter.com/BrentRichards19/status/1251550109931888643) showing an intronic SNP in LDLRAD4 as relevant. This pathway summarizes what is known of the biological role of this gene and its proteins.

Authors

Egon Willighagen , Friederike Ehrhart , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

disease pathway

Disease Ontology

disease by infectious agent

Participants
Query Drugst.One

Label Type Compact URI Comment
PMEPA1 GeneProduct ensembl:ENSG00000124225 Also known as TMEPAI
NEDD4 GeneProduct ensembl:ENSG00000069869
LDLRAD4 GeneProduct ensembl:ENSG00000168675 Also known as C18ORF1
SMAD2 GeneProduct ensembl:ENSG00000175387
ATG16L1 GeneProduct ensembl:ENSG00000085978
TGFBR2 GeneProduct ensembl:ENSG00000163513
TGFBR1 GeneProduct ensembl:ENSG00000106799

References

  1. Genome-wide association study of blood pressure and hypertension. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, et al. Nat Genet. 2009 Jun;41(6):677–87. PubMed Europe PMC Scholia
  2. TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells. Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S, Kato M. Cancer Sci. 2014 Mar;105(3):334–41. PubMed Europe PMC Scholia
  3. C18 ORF1, a novel negative regulator of transforming growth factor-β signaling. Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, et al. J Biol Chem. 2014 May 2;289(18):12680–92. PubMed Europe PMC Scholia
  4. MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury. Wang IK, Sun KT, Tsai TH, Chen CW, Chang SS, Yu TM, et al. Life Sci. 2015 Sep 1;136:133–41. PubMed Europe PMC Scholia
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. Cell. 2015 Jul 16;162(2):425–40. PubMed Europe PMC Scholia
  6. Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells. Liu Z, Huo X, Zhao S, Yang J, Shi W, Jing L, et al. Exp Cell Res. 2017 Nov 15;360(2):189–98. PubMed Europe PMC Scholia
  7. TMEPAI family: involvement in regulation of multiple signalling pathways. Itoh S, Itoh F. J Biochem. 2018 Sep 1;164(3):195–204. PubMed Europe PMC Scholia
  8. A large data resource of genomic copy number variation across neurodevelopmental disorders. Zarrei M, Burton CL, Engchuan W, Young EJ, Higginbotham EJ, MacDonald JR, et al. NPJ Genom Med. 2019 Oct 7;4:26. PubMed Europe PMC Scholia
  9. Association Between Side Effects and Blood microRNA Expression Levels and Their Targeted Pathways in Patients With Major Depressive Disorder Treated by a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report. Yrondi A, Fiori LM, Frey BN, Lam RW, MacQueen GM, Milev R, et al. Int J Neuropsychopharmacol. 2020 Feb 1;23(2):88–95. PubMed Europe PMC Scholia
  10. Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer. Mo S, Zhang L, Dai W, Han L, Wang R, Xiang W, et al. Cell Death Dis. 2020 Feb 28;11(2):155. PubMed Europe PMC Scholia