Cholestasis (WP5238)

Homo sapiens

Authors

Velina Pencheva , Susan Coort , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

cholestasis

Pathway Ontology

cholestasis pathway

Cell Type Ontology

hepatocyte

References

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2. Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding. Kassam A, Miao B, Young PR, Mukherjee R. J Biol Chem. 2003 Mar 21;278(12):10028–32. PubMed Europe PMC Scholia
3. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Mol Endocrinol. 2003 Feb;17(2):259–72. PubMed Europe PMC Scholia
4. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, et al. J Hepatol. 2003 Oct;39(4):480–8. PubMed Europe PMC Scholia
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6. The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. Friesen JA, Rodwell VW. Genome Biol. 2004;5(11):248. PubMed Europe PMC Scholia
7. Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. Yu L, Gupta S, Xu F, Liverman ADB, Moschetta A, Mangelsdorf DJ, et al. J Biol Chem. 2005 Mar 11;280(10):8742–7. PubMed Europe PMC Scholia
8. Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. Moffit JS, Aleksunes LM, Maher JM, Scheffer GL, Klaassen CD, Manautou JE. J Pharmacol Exp Ther. 2006 May;317(2):537–45. PubMed Europe PMC Scholia
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14. Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter. Renga B, Migliorati M, Mencarelli A, Cipriani S, D’Amore C, Distrutti E, et al. Biochim Biophys Acta. 2011 Mar;1809(3):157–65. PubMed Europe PMC Scholia
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22. Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. Dong B, Singh AB, Guo GL, Young M, Liu J. Int J Mol Med. 2019 May;43(5):1927–38. PubMed Europe PMC Scholia