Cytokines and inflammatory response (WP530)
Homo sapiens
Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Sources: [http://www.biocarta.com/pathfiles/h_inflamPathway.asp BioCarta].
Authors
Sebastien Burel , Alex Pico , Thomas Kelder , Ferry Jagers , Jack007 , Egon Willighagen , Ryan Miller , Kristina Hanspers , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
- Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor (2022).
- AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC (2022).
- Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIV-Associated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial (2021).
- A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection (2020).
- LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC (2020).
- Finding disease modules for cancer and COVID-19 in gene co-expression networks with the Core&Peel method (2020).
- Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale (2020).
- Transcriptional Analysis of T Cells Resident in Human Skin (2016).
- A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.
- Exploring the pharmacological mechanism of Duhuo Jisheng Decoction in treating intervertebral disc degeneration based on network pharmacology (2023).
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Cell Type Ontology
mast cell fibroblast B cell hematopoietic stem cell neutrophil helper T cell macrophage plasma cell endothelial cell natural killer cell eosinophilPathway Ontology
signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
IL1A | GeneProduct | ncbigene:3552 | |
IL1B | GeneProduct | ncbigene:3553 | |
TRA | GeneProduct | ncbigene:6955 | |
TGFB1 | GeneProduct | ncbigene:7040 | |
IL10 | GeneProduct | ncbigene:3586 | |
CD4 | GeneProduct | ncbigene:920 | |
IL3 | GeneProduct | ncbigene:16187 | |
IFN1@ | GeneProduct | ncbigene:3438 | |
IL4 | GeneProduct | ncbigene:3565 | |
IL3 | GeneProduct | ncbigene:3562 | |
IL13 | GeneProduct | ncbigene:3596 | |
CSF1 | GeneProduct | ncbigene:1435 | |
IL7 | GeneProduct | ncbigene:3574 | |
IFNG | GeneProduct | ncbigene:3458 | |
IL2 | GeneProduct | ncbigene:3558 | |
TRB | GeneProduct | ncbigene:6957 | |
CSF3 | GeneProduct | ncbigene:1440 | |
TNF | GeneProduct | ncbigene:7124 | |
IL15 | GeneProduct | ncbigene:3600 | |
IL5 | GeneProduct | ncbigene:3567 | |
CXCL2 | GeneProduct | ncbigene:2920 | |
CXCL1 | GeneProduct | ncbigene:2919 | |
IL6 | GeneProduct | ncbigene:3569 | |
IL12B | GeneProduct | ncbigene:3593 | |
HLA-DRA | GeneProduct | ncbigene:3122 | |
IL11 | GeneProduct | ncbigene:3589 | |
CSF2 | GeneProduct | ncbigene:1437 | |
IL12 | GeneProduct | ncbigene:3593 | |
PDGFA | GeneProduct | ncbigene:5154 | |
IFNB1 | GeneProduct | ncbigene:3456 | |
HLA-DRB1 | GeneProduct | ncbigene:3123 |
References
- Chemical biology of inflammatory cytokine signaling. Kataoka T. J Antibiot (Tokyo). 2009 Dec;62(12):655–67. PubMed Europe PMC Scholia