Cytokines and inflammatory response (WP530)

Homo sapiens

Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Sources: [http://www.biocarta.com/pathfiles/h_inflamPathway.asp BioCarta].

Authors

Sebastien Burel , Alex Pico , Thomas Kelder , Ferry Jagers , Jack007 , Egon Willighagen , Ryan Miller , Kristina Hanspers , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Cell Type Ontology

mast cell fibroblast B cell hematopoietic stem cell neutrophil helper T cell macrophage plasma cell endothelial cell natural killer cell eosinophil

Pathway Ontology

signaling pathway

Participants

Label Type Compact URI Comment
IL1A GeneProduct ncbigene:3552
IL1B GeneProduct ncbigene:3553
TRA GeneProduct ncbigene:6955
TGFB1 GeneProduct ncbigene:7040
IL10 GeneProduct ncbigene:3586
CD4 GeneProduct ncbigene:920
IL3 GeneProduct ncbigene:16187
IFN1@ GeneProduct ncbigene:3438
IL4 GeneProduct ncbigene:3565
IL3 GeneProduct ncbigene:3562
IL13 GeneProduct ncbigene:3596
CSF1 GeneProduct ncbigene:1435
IL7 GeneProduct ncbigene:3574
IFNG GeneProduct ncbigene:3458
IL2 GeneProduct ncbigene:3558
TRB GeneProduct ncbigene:6957
CSF3 GeneProduct ncbigene:1440
TNF GeneProduct ncbigene:7124
IL15 GeneProduct ncbigene:3600
IL5 GeneProduct ncbigene:3567
CXCL2 GeneProduct ncbigene:2920
CXCL1 GeneProduct ncbigene:2919
IL6 GeneProduct ncbigene:3569
IL12B GeneProduct ncbigene:3593
HLA-DRA GeneProduct ncbigene:3122
IL11 GeneProduct ncbigene:3589
CSF2 GeneProduct ncbigene:1437
IL12 GeneProduct ncbigene:3593
PDGFA GeneProduct ncbigene:5154
IFNB1 GeneProduct ncbigene:3456
HLA-DRB1 GeneProduct ncbigene:3123

References

  1. Chemical biology of inflammatory cytokine signaling. Kataoka T. J Antibiot (Tokyo). 2009 Dec;62(12):655–67. PubMed Europe PMC Scholia